Search Results - "Elgendy, Said"

Characterization of a Class of Peptide Boronates with Neutral P1 Side Chains as Highly Selective Inhibitors of Thrombin by Deadman, John J, Elgendy, Said, Goodwin, Christopher A, Green, Donovan, Baban, Jehan A, Patel, Geeta, Skordalakes, Emmanuel, Chino, Naoyoshi, Claeson, Goran

“…Z-D-Phe-Pro-boroMpg-OPin (9a)1,2 has been shown previously to be a highly specific inhibitor of thrombin in spite of lacking an arginine-like guanidino group…”
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Bifunctional Peptide Boronate Inhibitors of Thrombin:  Crystallographic Analysis of Inhibition Enhanced by Linkage to an Exosite 1 Binding Peptide by Skordalakes, Emmanuel, Elgendy, Said, Goodwin, Christopher A, Green, Donovan, Scully, Michael F, Kakkar, Vijay V, Freyssinet, Jean-Marie, Dodson, Guy, Deadman, John J

“…The affinity of the hirudin49-64 segment for exosite 1 of thrombin has been used previously to enhance the potency of simple competitive inhibitors [DiMaio,…”
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Design of a novel class of bifunctional thrombin inhibitors, synthesised by the first application of peptide boronates in solid phase chemistry by Elgendy, Said, Patel, Geeta, Green, Donovan, Goodwin, Christopher A., Scully, Michael F., Husman, Wahid, Skordalakes, Emmanuel, Kakkar, Vijay V., Deadman, John J.

“…Borologs containing peptide boronates are new bifunctional biologically active molecules which bind to and inhibit thrombin. These compounds are designed based…”
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The facile synthesis of O, O-Dialkyl α-halobenzylphosphonates from O, O-Dialkyl α-hydroxybenzylphosphonates by Green, Donovan, Elgendy, Said, Patel, Geeta, Baban, Jehan A., Skordalakes, Emmanuel, Husman, Wahid, Kakkar, Vijay V., Deadman, John

“…O, O-Dialkyl α-hydroxybenzylphosphonates ( 1) can be easily converted in their corresponding α-bromo ( 2) or α-iodo ( 3) phosphonates, in quantitative yield,…”
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Crystallographic Structures of Human α-Thrombin Complexed to Peptide Boronic Acids Lacking a Positive Charge at P1. Evidence of Novel Interactions by Skordalakes, Emmanuel, Tyrell, Richard, Elgendy, Said, Goodwin, Christopher A, Green, Donovan, Dodson, Guy, Scully, Michael F, Freyssinet, Jean-Marie H, Kakkar, Vijay V, Deadman, John J

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SUBSTRATE RELATED O,O-DIALKYLDIPEPTIDYLY ψ CARBOXYBENZYLPHOSPHONATES, A NEW TYPE OF THROMBIN INHIBITOR by Green, Donovan, Elgendy, Said, Patel, Geeta, Skordalakes, Emmanuel, Goodwin, Christopher A., Scully, Micheal F., Kakkar, Vijay V., Deadman, John J.

“…O,O-Dialkyl α-hydroxybenzylphosphonates (1) were coupled to substrate derived dipeptides (2). using an active ester methodology approach to generate a series…”
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Heparin enhances the catalytic activity of des-ETW-thrombin by Goodwin, C A, Deadman, J J, Le Bonniec, B F, Elgendy, S, Kakkar, V V, Scully, M F

“…The thrombin mutant, des-ETW-thrombin, lacking Glu(146), Thr(147), and Trp(148) within a unique insertion loop located at the extreme end of the primary…”
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New peptide boronic acid inhibitors of thrombin by Elgendy, S, Deadman, J, Claeson, G

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