Search Results - "Elgemeie, Galal H"

Medicinal Chemistry of Pyrazolopyrimidine Scaffolds Substituted with Different Heterocyclic Nuclei by Elgemeie, Galal H, Azzam, Rasha A, Zaghary, Wafaa A, Khedr, Mohammed A, Elsherif, Gihad E

“…Medicinal chemistry of pyrazolopyrimidine scaffolds substituted with different heterocyclic nuclei has attracted great attention due to their wide range of…”
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Efficient Synthesis and Docking Studies of Novel Benzothiazole-Based Pyrimidinesulfonamide Scaffolds as New Antiviral Agents and Hsp90α Inhibitors by Azzam, Rasha A, Osman, Rokia R, Elgemeie, Galal H

“…A series of novel substituted 2-pyrimidylbenzothiazoles incorporating either sulfonamide moieties or the amino group at C2 of the pyrimidine ring were…”
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Novel Synthesis and Antiviral Evaluation of New Benzothiazole-Bearing N‑Sulfonamide 2‑Pyridone Derivatives as USP7 Enzyme Inhibitors by Azzam, Rasha A, Elboshi, Heba A, Elgemeie, Galal H

“…In this article, a series of benzothiazole-bearing N-sulfonamide 2-pyridone derivatives were synthesized via the reaction of benzothiazole sulfonylhydrazide…”
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Synthesis of new sulfapyrimidine and pyrazolo[1,5-a]pyrimidine derivatives by Ahmed, Ebtsam A., Elgemeie, Galal H., Azzam, Rasha A.

“…A series of new pyrimidine derivatives were synthesized, including sulfapyrimidines and pyrazolo[1,5-a]pyrimidines. In basic medium, pyrimidine compounds were…”
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Design, Synthesis, and Antimicrobial Evaluation of a New Series of N‑Sulfonamide 2‑Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes by Azzam, Rasha A, Elsayed, Rasha E, Elgemeie, Galal H

“…Sulfonamides and trimethoprim (TMP) drugs are normally used to inhibit the action of dihydropteroate synthase (DHPS) and dihydrofolate reductase (DHFR)…”
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Design and Synthesis of a New Class of Pyridine-Based N‑Sulfonamides Exhibiting Antiviral, Antimicrobial, and Enzyme Inhibition Characteristics by Azzam, Rasha A, Elsayed, Rasha E, Elgemeie, Galal H

“…A new strategy for designing and assembling a novel class of functionalized pyridine-based benzothiazole and benzimidazole incorporating sulfonamide moieties…”
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Synthesis, Physicochemical Properties and Molecular Docking of New Benzothiazole Derivatives as Antimicrobial Agents Targeting DHPS Enzyme by Azzam, Rasha A, Elboshi, Heba A, Elgemeie, Galal H

“…The drug-resistance problem is widely spread and becoming more common in community-acquired and nosocomial strains of bacteria. Therefore, finding new…”
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Anti-Covid-19 Drug Analogues: Synthesis of Novel Pyrimidine Thioglycosides as Antiviral Agents Against SARS-COV‑2 and Avian Influenza H5N1 Viruses by Abu-Zaied, Mamdouh A, Elgemeie, Galal H, Mahmoud, Nashwa M

“…A class of pyrimidine thioglycoside analogs (6a–h) were synthesized from a reaction of 2-cyano-3,3-dimercapto-N-arylacrylamide (2a–d) and thiourea to produce…”
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Novel Thiophene Thioglycosides Substituted with the Benzothiazole Moiety: Synthesis, Characterization, Antiviral and Anticancer Evaluations, and NS3/4A and USP7 Enzyme Inhibitions by Azzam, Rasha A., Gad, Nagwa M., Elgemeie, Galal H.

“…Novel derivatives of benzothiazole-2-thiophene S-glycoside were synthesized and tested for their antiviral and anticancer potency and NS3/4A and USP7 enzyme…”
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Crystal structure of 2-[(5-amino-1-tosyl-1 H -pyrazol-3-yl)-oxy]-1-(4-meth-oxy-phen-yl)ethan-1-one 1,4-dioxane monosolvate by Metwally, Nadia H, Elgemeie, Galal H, Jones, Peter G

“…In the structure of the title compound, C H N O S·C H O , the two independent dioxane mol-ecules each display inversion symmetry. The pyrazole ring is…”
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Novel synthesis of new triazine sulfonamides with antitumor, anti-microbial and anti-SARS-CoV-2 activities by Mohamed-Ezzat, Reham A., Elgemeie, Galal H.

“…Novel approach for synthesizing triazine sulfonamide derivatives is accomplished via reacting the sulfaguanidine derivatives with N -cyanodithioiminocarbonate…”
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Crystal structure of 4-(benzo[d]thia-zol-2-yl)-1,2-dimethyl-1H-pyrazol-3(2H)-one by Elboshi, Heba A, Azzam, Rasha A, Elgemeie, Galal H, Jones, Peter G

“…In the title compound, C12H11N3OS, the inter-planar angle between the pyrazole and benzo-thia-zole rings is 3.31 (7)°. In the three-dimensional mol-ecular…”
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An unexpected tautomer: synthesis and crystal structure of N -[6-amino-4-(methyl-sulfan-yl)-1,2-di-hydro-1,3,5-triazin-2-yl-idene]benzenesulfonamide by Mohamed-Ezzat, Reham A, Elgemeie, Galal H, Jones, Peter G

“…The title compound, C H N O S , consists of an unexpected tautomer with a protonated nitro-gen atom in the triazine ring and a formal exocyclic double bond C=N…”
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Synthesis and crystal structure of N -phenyl-2-(phenyl-sulfan-yl)acetamide by Mohamed-Ezzat, Reham A, Kariuki, Benson M, Elgemeie, Galal H

“…-Phenyl-2-(phenyl-sulfan-yl)acetamide, C H NOS, was synthesized and structurally characterized. In the crystal, N-H⋯O hydrogen bonding leads to the formation…”
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Crystal structure of ethyl 2-(3-amino-5-oxo-2-tosyl-2,5-dihydro-1 H -pyrazol-1-yl)acetate by Metwally, Nadia H., Elgemeie, Galal H., Jones, Peter G.

“…In the title compound, C 14 H 17 N 3 O 5 S, the five-membered ring is essentially planar. The substituents at the nitrogen atoms subtend a C—N—N—S torsion…”
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Crystal structure of 3-(benzodthia-zol-2-yl)-6-methyl-2H-chromen-2-one by Abdallah, Amira E M, Elgemeie, Galal H, Jones, Peter G

“…The mol-ecule of the title compound, C17H11NO2S, is almost planar, with an inter-planar angle of 3.01 (3)° between the benzo-thia-zole and chromene ring…”
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Crystal structure of ( E )- N -(4-bromo-phen-yl)-2-cyano-3-[3-(2-methyl-prop-yl)-1-phenyl-1 H -pyrazol-4-yl]prop-2-enamide by Abu-Zaied, Mamdouh A, Mohamed-Ezzat, Reham A, Elgemeie, Galal H, Jones, Peter G

“…The structure of the title compound, C H BrN O, contains two independent mol-ecules connected by hydrogen bonds of the type N -H⋯N≡C to form a dimer. The…”
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New Route to the Synthesis of Benzamide-Based 5‑Aminopyrazoles and Their Fused Heterocycles Showing Remarkable Antiavian Influenza Virus Activity by Hebishy, Ali M. S, Salama, Hagar T, Elgemeie, Galal H

“…This study describes a new route to the synthesis of novel benzamide-based 5-aminopyrazoles and their corresponding pyrazolo­[1,5-a]­pyrimidine and…”
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Crystal structure of ethyl 2-(5-amino-1-benzene-sulfonyl-3-oxo-2,3-di-hydro-1 H -pyrazol-2-yl)acetate by Metwally, Nadia H, Elgemeie, Galal H, Jones, Peter G

“…In the title compound, C H N O S, the two rings face each other in a 'V' form at the S atom, with one N-H⋯O=S and one C-H⋯O=S contact from the pyrazolyl…”
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Toward Developing Therapies against Corona Virus: Synthesis and Anti-Avian Influenza Virus Activity of Novel Cytosine Thioglycoside Analogues by Abu-Zaied, Mamdouh A, Mahmoud, Nashwa M, Elgemeie, Galal H

“…A series of pyrimidine and pyrimidine thioglycoside derivatives were newly synthesized using sodium 2-cyano-3-(arylamino)­prop-1-ene-1,1-bis­(thiolates) and…”
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