Search Results - "Elgebaly, A."
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Integrated Bioinformatics Analysis Confirms the Diagnostic Value of Nourin-Dependent miR-137 and miR-106b in Unstable Angina Patients
Published in International journal of molecular sciences (01-10-2023)“…The challenge of rapidly diagnosing myocardial ischemia in unstable angina (UA) patients presenting to the Emergency Department (ED) is due to a lack of…”
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Cyclocreatine Phosphate: A Novel Bioenergetic/Anti-Inflammatory Drug That Resuscitates Poorly Functioning Hearts and Protects against Development of Heart Failure
Published in Pharmaceuticals (Basel, Switzerland) (01-03-2023)“…Irreversible myocardial injury causes the exhaustion of cellular adenosine triphosphate (ATP) contributing to heart failure (HF). Cyclocreatine phosphate…”
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Nourin-Associated miRNAs: Novel Inflammatory Monitoring Markers for Cyclocreatine Phosphate Therapy in Heart Failure
Published in International journal of molecular sciences (30-03-2021)“…Cyclocreatine phosphate (CCrP) is a potent bioenergetic cardioprotective compound known to preserve high levels of cellular adenosine triphosphate during…”
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Consumption of Terpenoids-Rich Padina pavonia Extract Attenuates Hyperglycemia, Insulin Resistance and Oxidative Stress, and Upregulates PPARγ in a Rat Model of Type 2 Diabetes
Published in Antioxidants (26-12-2019)“…Seaweeds are rich in structurally diverse bioactive compounds with promising therapeutic effects. This study aimed to isolate and identify terpenes from the…”
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Green Synthesis of Trimetallic Nanocomposite (Ru/Ag/Pd)-Np and Its In Vitro Antimicrobial and Anticancer Activities
Published in Journal of chemistry (15-09-2022)“…In this study, we used the aqueous extract of garlic tunicate leaf to reduce a mixture of equal amounts of ruthenium chloride, silver nitrate, and palladium…”
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Smartphone-based point-of-care testing of the SARS-CoV-2: A systematic review
Published in Scientific African (01-09-2023)“…The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus's worldwide pandemic has highlighted the urgent need for reliable, quick, and affordable…”
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Nourin-Dependent miR-137 and miR-106b: Novel Early Inflammatory Diagnostic Biomarkers for Unstable Angina Patients
Published in Biomolecules (Basel, Switzerland) (28-02-2021)“…Currently, no blood biomarkers exist that can diagnose unstable angina (UA) patients. Nourin is an early inflammatory mediator rapidly released within 5 min by…”
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Sofosbuvir Plus Velpatasvir for Chronic HCV Genotype 1, 2, 3, and 4 Infection
Published in Journal of hepatology (2016)Get full text
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Development and validation of an LC‒MS/MS method for the determination of cyclocreatine phosphate and its related endogenous biomolecules in rat heart tissues
Published in BMC chemistry (04-11-2024)“…The cardioprotective drug cyclocreatine phosphate has been awarded Food and Drug Administration-orphan drug designation for the prevention of ischemic injury…”
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Nourin-Dependent miR-137 and miR-106b: Novel Biomarkers for Early Diagnosis of Myocardial Ischemia in Coronary Artery Disease Patients
Published in Diagnostics (Basel) (14-04-2021)“…Although cardiovascular imaging techniques are widely used to diagnose myocardial ischemia in patients with suspected stable coronary artery disease (CAD),…”
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Impedimetric Sensors for Cyclocreatine Phosphate Determination in Plasma Based on Electropolymerized Poly(o‑phenylenediamine) Molecularly Imprinted Polymers
Published in ACS omega (23-11-2021)“…Cyclocreatine and its water-soluble derivative, cyclocreatine phosphate (CCrP), are potent cardioprotective drugs. Based on recent animal studies, CCrP,…”
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Olive oil and leaf extract prevent fluoxetine-induced hepatotoxicity by attenuating oxidative stress, inflammation and apoptosis
Published in Biomedicine & pharmacotherapy (01-02-2018)“…[Display omitted] •Fluoxetine induces oxidative stress, inflammation and apoptosis.•Olive oil and leaf extract prevent fluoxetine-induced liver injury.•Olive…”
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Umbelliferone prevents oxidative stress, inflammation and hematological alterations, and modulates glutamate-nitric oxide-cGMP signaling in hyperammonemic rats
Published in Biomedicine & pharmacotherapy (01-06-2018)“…[Display omitted] Hepatic encephalopathy (HE) is a serious neuropsychiatric complication that occurs as a result of liver failure. Umbelliferone (UMB;…”
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Coenzyme Q10 mitigates cadmium cardiotoxicity by downregulating NF-κB/NLRP3 inflammasome axis and attenuating oxidative stress in mice
Published in Life sciences (1973) (01-07-2024)“…Coenzyme Q10 (CoQ10) occurs naturally in the body and possesses antioxidant and cardioprotective effects. Cardiotoxicity has emerged as a serious effect of the…”
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Galangin attenuates chlorpyrifos-induced kidney injury by mitigating oxidative stress and inflammation and upregulating Nrf2 and farnesoid-X-receptor in rats
Published in Environmental toxicology and pharmacology (01-09-2024)“…Chlorpyrifos (CPF) is a highly toxic commonly used pesticide and can seriously harm human health. This study assessed the potential of galangin (GAL), an…”
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Farnesol attenuates oxidative stress and liver injury and modulates fatty acid synthase and acetyl-CoA carboxylase in high cholesterol-fed rats
Published in Environmental science and pollution research international (01-08-2020)“…Dyslipidemia is a risk factor for cardiovascular disease, steatohepatitis, and progression of liver disorders. This study investigated the protective effect of…”
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A flavonoid-rich fraction of Monolluma quadrangula inhibits xanthine oxidase and ameliorates potassium oxonate-induced hyperuricemia in rats
Published in Environmental science and pollution research international (01-09-2022)“…Hyperuricemia represents a risk factor for the progression of chronic kidney disease. Oxidative stress and inflammation are implicated in the mechanisms…”
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Novel biosynthesis of Ag-nanocomplex for controlling Verticillium wilt disease of olive tree
Published in Archiv für Phytopathologie und Pflanzenschutz (20-01-2022)“…The nano-metal complexes are found to be more impregnable than their parent drugs, therefore this study was aimed to synthesize Ag-nanocomplex of paracetamol…”
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Ameliorative effect of propolis against cyclophosphamide-induced toxicity in mice
Published in Pharmaceutical biology (01-02-2015)“…Cyclophosphamide (CTX) is a common anticancer agent used for the treatment of several malignancies. However, upon treatment, it induces severe toxicity due to…”
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Efficacy of Rosmarinus officinalis leaves extract against cyclophosphamide-induced hepatotoxicity
Published in Pharmaceutical biology (02-10-2016)“…Context Cyclophosphamide (CTX) is used to treat different cancer types, although it causes severe hepatotoxicity due to its oxidative stress effect. Rosmarinus…”
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