Changes in Serum Leptin Level After Multilevel Surgery in Patients with Obstructive Sleep Apnea

Changes in Serum Leptin Level After Multilevel Surgery in Patients with Obstructive Sleep Apnea

Objective Leptin hormone plays an important role in metabolic control and is elevated in obstructive sleep apnea (OSA). The aim of this study was to assess the hypothesis that surgical treatment will reduce leptin levels in OSA patients. Study Design Prospective study. Subjects and Methods Twenty‐th...

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Published in:The Laryngoscope Vol. 131; no. 2; pp. E665 - E670
Main Authors: Emara, Tarek A., Khazbak, Alaa O., Mohammed, Omnya, Elgaml, Mohamed, Zidan, Amal, Hosny, Sameh M.
Format: Journal Article
Language:English
Published: Hoboken, USA John Wiley & Sons, Inc 01-02-2021
Wiley Subscription Services, Inc
Subjects:
Adult
Humans
Laryngoscopy
Leptin - blood
Male
Middle Aged
Pharynx - surgery
Polysomnography
Prospective Studies
Serum leptin, multilevel obstruction, obstructive sleep apnea, genioglossus advancement, pharyngoplasty
Sleep apnea
Sleep Apnea, Obstructive - blood
Sleep Apnea, Obstructive - surgery
Surgery
Tongue - surgery
Serum leptin, multilevel obstruction, obstructive sleep apnea, genioglossus advancement, pharyngoplasty
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Summary:Objective Leptin hormone plays an important role in metabolic control and is elevated in obstructive sleep apnea (OSA). The aim of this study was to assess the hypothesis that surgical treatment will reduce leptin levels in OSA patients. Study Design Prospective study. Subjects and Methods Twenty‐three patients with multilevel OSA underwent modified genioglossus muscle advancement with anterolateral advancement pharyngoplasty between April 2018 and September 2019. Serum leptin level was measured preoperatively and 3 months postoperatively for all patients and 18 control subjects. All patients were evaluated before and 3 months after surgery by history taking, clinical examination, polysomnography, cephalometry, and Epworth Sleepiness Scale. Results Preoperatively, patients with OSA had a higher Leptin level (18.46 ± 4.73 ng/mL) than did control subjects (7.07 ± 1.26 ng/mL) (P < .001). Surgery resulted in a significant reduction in the level of leptin from 18.46 ± 4.73 ng/mL to 8.03 ± 2.22 ng/mL (P < .001). Reductions in leptin level was correlated with changes in apnea hypopnea index (AHI) (r = 0.61, P = .002) and minimum oxygen saturation (SaO2) (r = −0.54, P = .008). Conclusion Effective multilevel surgery in the form of modified genioglossus muscle advancement with anterolateral advancement pharyngoplasty could significantly reduce leptin level in OSA patients and this reduction is correlated with the degree of OSA improvement in term of AHI and SaO2. Level of Evidence 4 Laryngoscope, 131:E665–E670, 2021
Bibliography:The authors have no funding or conflicts of interest to disclose. (prospective study)
Editor's Note: This Manuscript was accepted for publication on June 16, 2020.
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SourceType-Scholarly Journals-1
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ISSN:0023-852X
1531-4995
DOI:10.1002/lary.28908