Search Results - "Elferink, Oude"

ABCC6–Mediated ATP Secretion by the Liver Is the Main Source of the Mineralization Inhibitor Inorganic Pyrophosphate in the Systemic Circulation—Brief Report by Jansen, Robert S, Duijst, Suzanne, Mahakena, Sunny, Sommer, Daniela, Szeri, Flóra, Váradi, András, Plomp, Astrid, Bergen, Arthur A, Oude Elferink, Ronald P.J, Borst, Piet, van de Wetering, Koen

“…OBJECTIVE—Mutations in ABCC6 underlie the ectopic mineralization disorder pseudoxanthoma elasticum (PXE) and some forms of generalized arterial calcification…”
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Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: Conjugated hypercholanemia without a clear clinical phenotype by Vaz, Frédéric M., Paulusma, Coen C., Huidekoper, Hidde, de Ru, Minke, Lim, Cynthia, Koster, Janet, Ho‐Mok, Kam, Bootsma, Albert H., Groen, Albert K., Schaap, Frank G., Oude Elferink, Ronald P. J., Waterham, Hans R., Wanders, Ronald J.A.

“…The enterohepatic circulation of bile salts is an important physiological route to recycle bile salts and ensure intestinal absorption of dietary lipids. The…”
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Mechanisms of pruritus in cholestasis: understanding and treating the itch by Beuers, Ulrich, Wolters, Frank, Oude Elferink, Ronald P. J.

“…Pruritus in cholestatic liver diseases can be a major burden and dramatically impair the quality of life of those affected. Here, we provide an update on the…”
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Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions by Kremer, Andreas E., van Dijk, Remco, Leckie, Pamela, Schaap, Frank G., Kuiper, Edith M.M., Mettang, Thomas, Reiners, Katrin S., Raap, Ulrike, van Buuren, Henk R., van Erpecum, Karel J., Davies, Nathan A., Rust, Christian, Engert, Andreas, Jalan, Rajiv, Oude Elferink, Ronald P.J., Beuers, Ulrich

“…Pruritus is a seriously disabling symptom accompanying many cholestatic liver disorders. Recent experimental evidence implicated the lysophospholipase,…”
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Primary biliary cirrhosis by Hohenester, Simon, Oude-Elferink, Ronald P. J., Beuers, Ulrich

“…Primary biliary cirrhosis (PBC) is an immune-mediated chronic cholestatic liver disease with a slowly progressive course. Without treatment, most patients…”
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Reduced hepatitis B and D viral entry using clinically applied drugs as novel inhibitors of the bile acid transporter NTCP by Donkers, Joanne M., Zehnder, Benno, van Westen, Gerard J. P., Kwakkenbos, Mark J., IJzerman, Adriaan P., Oude Elferink, Ronald P. J., Beuers, Ulrich, Urban, Stephan, van de Graaf, Stan F. J.

“…The sodium taurocholate co-transporting polypeptide (NTCP, SLC10A1 ) is the main hepatic transporter of conjugated bile acids, and the entry receptor for…”
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Lysophosphatidic Acid Is a Potential Mediator of Cholestatic Pruritus by Kremer, Andreas E, Martens, Job J.W.W, Kulik, Wim, Ruëff, Franziska, Kuiper, Edith M.M, van Buuren, Henk R, van Erpecum, Karel J, Kondrackiene, Jurate, Prieto, Jesus, Rust, Christian, Geenes, Victoria L, Williamson, Catherine, Moolenaar, Wouter H, Beuers, Ulrich, Oude Elferink, Ronald P.J

“…Background & Aims Pruritus is a common and disabling symptom in cholestatic disorders. However, its causes remain unknown. We hypothesized that potential…”
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Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein) by Oude Elferink, Ronald P J, Paulusma, Coen C

“…Like several other ATP-binding cassette (ABC) transporters, ABCB4 is a lipid translocator. It translocates phosphatidylcholine (PC) from the inner to the outer…”
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A biliary HCO3− umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes by Hohenester, Simon, Maillette de Buy Wenniger, Lucas, Paulusma, Coen C., van Vliet, Sandra J., Jefferson, Douglas M., Oude Elferink, Ronald P., Beuers, Ulrich

“…Human cholangiocytes are continuously exposed to millimolar levels of hydrophobic bile salt monomers. We recently hypothesized that an apical biliary HCO 3−…”
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MAMMALIAN ABC TRANSPORTERS IN HEALTH AND DISEASE by Borst, P, Elferink, R. Oude

“…The ATP-binding cassette (ABC) transporters are a family of large proteins in membranes and are able to transport a variety of compounds through membranes…”
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Hepatic uptake of conjugated bile acids is mediated by both sodium taurocholate cotransporting polypeptide and organic anion transporting polypeptides and modulated by intestinal sensing of plasma bile acid levels in mice by Slijepcevic, Davor, Roscam Abbing, Reinout L.P., Katafuchi, Takeshi, Blank, Antje, Donkers, Joanne M., van Hoppe, Stéphanie, de Waart, Dirk. R., Tolenaars, Dagmar, van der Meer, Jonathan H.M., Wildenberg, Manon, Beuers, Ulrich, Oude Elferink, Ronald P.J., Schinkel, Alfred H., van de Graaf, Stan F.J.

“…The Na+‐taurocholate cotransporting polypeptide (NTCP/SLC10A1) is believed to be pivotal for hepatic uptake of conjugated bile acids. However, plasma bile acid…”
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Phospholipid flippases attenuate LPS-induced TLR4 signaling by mediating endocytic retrieval of Toll-like receptor 4 by van der Mark, Vincent A., Ghiboub, Mohammed, Marsman, Casper, Zhao, Jing, van Dijk, Remco, Hiralall, Johan K., Ho-Mok, Kam S., Castricum, Zoë, de Jonge, Wouter J., Oude Elferink, Ronald P. J., Paulusma, Coen C.

“…P4-ATPases are lipid flippases that catalyze the transport of phospholipids to create membrane phospholipid asymmetry and to initiate the biogenesis of…”
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The extracellular lactate-to-pyruvate ratio modulates the sensitivity to oxidative stress-induced apoptosis via the cytosolic NADH/NAD+ redox state by Go, Simei, Kramer, Thorquil T., Verhoeven, Arthur J., Oude Elferink, Ronald P. J., Chang, Jung-Chin

“…The advantages of the Warburg effect on tumor growth and progression are well recognized. However, the relevance of the Warburg effect for the inherent…”
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PPARα, PPARδ, or both-that is the question by Wolters, Frank, Oude Elferink, Ronald P J, Beuers, Ulrich

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Intestinal Farnesoid X Receptor Controls Transintestinal Cholesterol Excretion in Mice by de Boer, Jan Freark, Schonewille, Marleen, Boesjes, Marije, Wolters, Henk, Bloks, Vincent W, Bos, Trijnie, van Dijk, Theo H, Jurdzinski, Angelika, Boverhof, Renze, Wolters, Justina C, Kuivenhoven, Jan A, van Deursen, Jan M, Oude Elferink, Ronald P.J, Moschetta, Antonio, Kremoser, Claus, Verkade, Henkjan J, Kuipers, Folkert, Groen, Albert K

“…Background & Aims The role of the intestine in the maintenance of cholesterol homeostasis increasingly is recognized. Fecal excretion of cholesterol is the…”
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Targeting the Four Pillars of Enterohepatic Bile Salt Cycling; Lessons From Genetics and Pharmacology by Kunst, Roni F., Verkade, Henkjan J., Oude Elferink, Ronald P.J., Graaf, Stan F.J.

“…Bile salts play a pivotal role in lipid homeostasis, are sensed by specialized receptors, and have been implicated in various disorders affecting the gut or…”
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Effect of ileal bile acid transporter inhibitor GSK2330672 on pruritus in primary biliary cholangitis: a double-blind, randomised, placebo-controlled, crossover, phase 2a study by Hegade, Vinod S, Dr, Kendrick, Stuart F W, PhD, Dobbins, Robert L, MD, Miller, Sam R, MSc, Thompson, Douglas, PhD, Richards, Duncan, FRCP, Storey, James, PhD, Dukes, George E, PharmD, Corrigan, Margaret, MRCP, Oude Elferink, Ronald P J, PhD, Beuers, Ulrich, Prof, Hirschfield, Gideon M, Prof, Jones, David E, Prof

“…Summary Background Up to 70% of patients with primary biliary cholangitis develop pruritus (itch) during the course of their disease. Treatment of pruritus in…”
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Gene Therapy for Progressive Familial Intrahepatic Cholestasis: Current Progress and Future Prospects by Bosma, Piter J, Wits, Marius, Oude-Elferink, Ronald Pj

“…Progressive Familial Intrahepatic Cholestasis (PFIC) are inherited severe liver disorders presenting early in life, with high serum bile salt and bilirubin…”
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Annexin A11 is targeted by IgG4 and IgG1 autoantibodies in IgG4-related disease by Hubers, Lowiek M, Vos, Harmjan, Schuurman, Alex R, Erken, Robin, Oude Elferink, Ronald P, Burgering, Boudewijn, van de Graaf, Stan F J, Beuers, Ulrich

“…Immunoglobulin G4-related disease (IgG4-RD) is a multiorgan immune-mediated disease that predominantly affects the biliary tract (IgG4-associated cholangitis,…”
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Liver-directed gene therapy results in long-term correction of progressive familial intrahepatic cholestasis type 3 in mice by Aronson, Sem J., Bakker, Robert S., Shi, Xiaoxia, Duijst, Suzanne, ten Bloemendaal, Lysbeth, de Waart, Dirk R., Verheij, Joanne, Ronzitti, Giuseppe, Oude Elferink, Ronald P., Beuers, Ulrich, Paulusma, Coen C., Bosma, Piter J.

“…[Display omitted] •Adeno-associated virus (AAV)-mediated gene therapy can correct Abcb4 deficiency (PFIC3) in mice.•By restoring phospholipid transport to…”
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