Search Results - "Eles, James R."

ROS responsive resveratrol delivery from LDLR peptide conjugated PLA-coated mesoporous silica nanoparticles across the blood-brain barrier by Shen, Yang, Cao, Bin, Snyder, Noah R, Woeppel, Kevin M, Eles, James R, Cui, Xinyan Tracy

“…Oxidative stress acts as a trigger in the course of neurodegenerative diseases and neural injuries. An antioxidant-based therapy can be effective to ameliorate…”
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Calcium activation of cortical neurons by continuous electrical stimulation: Frequency dependence, temporal fidelity, and activation density by Michelson, Nicholas J., Eles, James R., Vazquez, Alberto L., Ludwig, Kip A., Kozai, Takashi D. Y.

“…Electrical stimulation of the brain has become a mainstay of fundamental neuroscience research and an increasingly prevalent clinical therapy. Despite decades…”
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Explant Analysis of Utah Electrode Arrays Implanted in Human Cortex for Brain-Computer-Interfaces by Woeppel, Kevin, Hughes, Christopher, Herrera, Angelica J, Eles, James R, Tyler-Kabara, Elizabeth C, Gaunt, Robert A, Collinger, Jennifer L, Cui, Xinyan Tracy

“…Brain-computer interfaces are being developed to restore movement for people living with paralysis due to injury or disease. Although the therapeutic potential…”
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A Materials Roadmap to Functional Neural Interface Design by Wellman, Steven M., Eles, James R., Ludwig, Kip A., Seymour, John P., Michelson, Nicholas J., McFadden, William E., Vazquez, Alberto L., Kozai, Takashi D. Y.

“…Advancements in neurotechnologies for electrophysiology, neurochemical sensing, neuromodulation, and optogenetics are revolutionizing scientific understanding…”
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In vivo imaging of calcium and glutamate responses to intracortical microstimulation reveals distinct temporal responses of the neuropil and somatic compartments in layer II/III neurons by Eles, James R., Kozai, Takashi D.Y.

“…Intracortical microelectrode implants can generate a tissue response hallmarked by glial scarring and neuron cell death within 100–150 μm of the biomaterial…”
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In vivo spatiotemporal patterns of oligodendrocyte and myelin damage at the neural electrode interface by Chen, Keying, Wellman, Steven M., Yaxiaer, Yalikun, Eles, James R., Kozai, Takashi DY

“…Intracortical microelectrodes with the ability to detect intrinsic electrical signals and/or deliver electrical stimulation into local brain regions have been…”
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Unique electrophysiological and impedance signatures between encapsulation types: An analysis of biological Utah array failure and benefit of a biomimetic coating in a rat model by Cody, Patrick A., Eles, James R., Lagenaur, Carl F., Kozai, Takashi D.Y., Cui, X.Tracy

“…Intracortical microelectrode arrays, especially the Utah array, remain the most common choice for obtaining high dimensional recordings of spiking neural…”
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In vivo spatiotemporal dynamics of astrocyte reactivity following neural electrode implantation by Savya, Sajishnu P., Li, Fan, Lam, Stephanie, Wellman, Steven M., Stieger, Kevin C., Chen, Keying, Eles, James R., Kozai, Takashi D.Y.

“…Brain computer interfaces (BCIs), including penetrating microelectrode arrays, enable both recording and stimulation of neural cells. However, device…”
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Neuroadhesive L1 coating attenuates acute microglial attachment to neural electrodes as revealed by live two-photon microscopy by Eles, James, Vazquez, Alberto L, Snyder, Noah R, Lagenaur, Carl, Murphy, Matthew C, Kozai, Takashi D.Y, Cui, X. Tracy

“…Abstract Implantable neural electrode technologies for chronic neural recordings can restore functional control to paralysis and limb loss victims through…”
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Multi-scale, multi-modal analysis uncovers complex relationship at the brain tissue-implant neural interface: new emphasis on the biological interface by Michelson, Nicholas J, Vazquez, Alberto L, Eles, James R, Salatino, Joseph W, Purcell, Erin K, Williams, Jordan J, Cui, X Tracy, Kozai, Takashi D Y

“…Implantable neural electrode devices are important tools for neuroscience research and have an increasing range of clinical applications. However, the…”
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In vivo imaging of neuronal calcium during electrode implantation: Spatial and temporal mapping of damage and recovery by Eles, James R., Vazquez, Alberto L., Kozai, Takashi D.Y., Cui, X. Tracy

“…Implantable electrode devices enable long-term electrophysiological recordings for brain-machine interfaces and basic neuroscience research. Implantation of…”
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In vivo microstimulation with cathodic and anodic asymmetric waveforms modulates spatiotemporal calcium dynamics in cortical neuropil and pyramidal neurons of male mice by Stieger, Kevin C., Eles, James R., Ludwig, Kip A., Kozai, Takashi D. Y.

“…Electrical stimulation has been critical in the development of an understanding of brain function and disease. Despite its widespread use and obvious clinical…”
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Hierarchically aligned fibrous hydrogel films through microfluidic self‐assembly of graphene and polysaccharides by Patel, Akhil, Xue, Yingfei, Hartley, Rebecca, Sant, Vinayak, Eles, James R., Cui, Xinyan Tracy, Stolz, Donna Beer, Sant, Shilpa

“…Despite significant interest in developing extracellular matrix (ECM)‐inspired biomaterials to recreate native cell‐instructive microenvironments, the major…”
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Two-photon imaging of chronically implanted neural electrodes: Sealing methods and new insights by Kozai, Takashi D.Y., Eles, James R., Vazquez, Alberto L., Cui, X. Tracy

“…•Silastic sealants limit cell infiltration into the craniotomy and improve image clarity.•Low concentration hydrogel sealants failed to prevent cell…”
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The temporal pattern of intracortical microstimulation pulses elicits distinct temporal and spatial recruitment of cortical neuropil and neurons by Eles, James R, Stieger, Kevin C, Kozai, Takashi D Y

“…The temporal spacing or distribution of stimulation pulses in therapeutic neurostimulation waveforms-referred to here as the Temporal Pattern (TP)-has emerged…”
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Intracortical microstimulation pulse waveform and frequency recruits distinct spatiotemporal patterns of cortical neuron and neuropil activation by Stieger, Kevin C, Eles, James R, Ludwig, Kip A, Kozai, Takashi D Y

“… Neural prosthetics often use intracortical microstimulation (ICMS) for sensory restoration. To restore natural and functional feedback, we must first…”
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Electrode sharpness and insertion speed reduce tissue damage near high-density penetrating arrays by McNamara, Ingrid N, Wellman, Steven M, Li, Lehong, Eles, James R, Savya, Sajishnu, Sohal, Harbaljit S, Angle, Matthew R, Kozai, Takashi D Y

“… Over the past decade, neural electrodes have played a crucial role in bridging biological tissues with electronic and robotic devices. This study focuses on…”
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Inhibition of Na + /H + exchanger modulates microglial activation and scar formation following microelectrode implantation by Dubaniewicz, Mitchell, Eles, James R, Lam, Stephanie, Song, Shanshan, Cambi, Franca, Sun, Dandan, Wellman, Steven M, Kozai, Takashi D Y

“…Intracortical microelectrodes are an important tool for neuroscience research and have great potential for clinical use. However, the use of microelectrode…”
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Zwitterionic Polymer Coating Suppresses Microglial Encapsulation to Neural Implants In Vitro and In Vivo by Yang, Qianru, Wu, Bingchen, Eles, James R., Vazquez, Alberto L., Kozai, Takashi D. Y., Cui, X. Tracy

“…For brain computer interfaces (BCI), the immune response to implanted electrodes is a major biological cause of device failure. Bioactive coatings such as…”
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