Search Results - "Elena Magrini"

PTX3, a Humoral Pattern Recognition Molecule, in Innate Immunity, Tissue Repair, and Cancer by Garlanda, Cecilia, Bottazzi, Barbara, Magrini, Elena, Inforzato, Antonio, Mantovani, Alberto

“…Innate immunity includes a cellular and a humoral arm. PTX3 is a fluid-phase pattern recognition molecule conserved in evolution which acts as a key component…”
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The Dual Complexity of PTX3 in Health and Disease: A Balancing Act? by Magrini, Elena, Mantovani, Alberto, Garlanda, Cecilia

“…The humoral arm of innate immunity is complex and includes various molecules that serve as markers of inflammation with complementary characteristics, such as…”
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The Long Pentraxin PTX3 as a Link Between Innate Immunity, Tissue Remodeling, and Cancer by Doni, Andrea, Stravalaci, Matteo, Inforzato, Antonio, Magrini, Elena, Mantovani, Alberto, Garlanda, Cecilia, Bottazzi, Barbara

“…The innate immune system comprises a cellular and a humoral arm. Humoral pattern recognition molecules include complement components, collectins, ficolins, and…”
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Negative Regulation of the IL-1 System by IL-1R2 and IL-1R8: Relevance in Pathophysiology and Disease by Supino, Domenico, Minute, Luna, Mariancini, Andrea, Riva, Federica, Magrini, Elena, Garlanda, Cecilia

“…Interleukin-1 (IL-1) is a primary cytokine of innate immunity and inflammation. IL-1 belongs to a complex family including ligands with agonist activity,…”
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Spatial distribution of B cells predicts prognosis in human pancreatic adenocarcinoma by Castino, Giovanni Francesco, Cortese, Nina, Capretti, Giovanni, Serio, Simone, Di Caro, Giuseppe, Mineri, Rossana, Magrini, Elena, Grizzi, Fabio, Cappello, Paola, Novelli, Francesco, Spaggiari, Paola, Roncalli, Massimo, Ridolfi, Cristina, Gavazzi, Francesca, Zerbi, Alessandro, Allavena, Paola, Marchesi, Federica

“…B-cell responses are emerging as critical regulators of cancer progression. In this study, we investigated the role of B lymphocytes in the microenvironment of…”
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Serum amyloid P component is an essential element of resistance against Aspergillus fumigatus by Doni, Andrea, Parente, Raffaella, Laface, Ilaria, Magrini, Elena, Cunha, Cristina, Colombo, Federico Simone, Lacerda, João, Campos, António, Mapelli, Sarah N., Petroni, Francesca, Porte, Rémi, Schorn, Tilo, Inforzato, Antonio, Mercier, Toine, Lagrou, Katrien, Maertens, Johan, Lambris, John D., Bottazzi, Barbara, Garlanda, Cecilia, Botto, Marina, Carvalho, Agostinho, Mantovani, Alberto

“…© The Author(s) 2021. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing,…”
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Multiplexed Imaging Mass Cytometry Analysis in Preclinical Models of Pancreatic Cancer by Erreni, Marco, Fumagalli, Maria Rita, Zanini, Damiano, Candiello, Ermes, Tiberi, Giorgia, Parente, Raffaella, D'Anna, Raffaella, Magrini, Elena, Marchesi, Federica, Cappello, Paola, Doni, Andrea

“…Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers. PDAC is characterized by a complex tumor microenvironment (TME), that plays a…”
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Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization by Magrini, Elena, Villa, Alessandra, Angiolini, Francesca, Doni, Andrea, Mazzarol, Giovanni, Rudini, Noemi, Maddaluno, Luigi, Komuta, Mina, Topal, Baki, Prenen, Hans, Schachner, Melitta, Confalonieri, Stefano, Dejana, Elisabetta, Bianchi, Fabrizio, Mazzone, Massimiliano, Cavallaro, Ugo

“…While tumor blood vessels share many characteristics with normal vasculature, they also exhibit morphological and functional aberrancies. For example, the…”
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The Long Pentraxin PTX3 Controls Klebsiella Pneumoniae Severe Infection by Asgari, Fatemeh, Supino, Domenico, Parente, Raffaella, Polentarutti, Nadia, Stravalaci, Matteo, Porte, Remi, Pasqualini, Fabio, Barbagallo, Marialuisa, Perucchini, Chiara, Recordati, Camilla, Magrini, Elena, Mariancini, Andrea, Riva, Federica, Giordano, Alessia, Davoudian, Sadaf, Roger, Thierry, Veer, Cornelis van’t, Jaillon, Sebastien, Mantovani, Alberto, Doni, Andrea, Garlanda, Cecilia

“…Klebsiella pneumoniae is a common pathogen in human sepsis. The emergence of multidrug-resistant K. pneumoniae strains represents a major clinical challenge in…”
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The long Pentraxin PTX3 serves as an early predictive biomarker of co-infections in COVID-19 by Scavello, Francesco, Brunetta, Enrico, Mapelli, Sarah N., Nappi, Emanuele, García Martín, Ian David, Sironi, Marina, Leone, Roberto, Solano, Simone, Angelotti, Giovanni, Supino, Domenico, Carnevale, Silvia, Zhong, Hang, Magrini, Elena, Stravalaci, Matteo, Protti, Alessandro, Santini, Alessandro, Costantini, Elena, Savevski, Victor, Voza, Antonio, Bottazzi, Barbara, Bartoletti, Michele, Cecconi, Maurizio, Mantovani, Alberto, Morelli, Paola, Tordato, Federica, Garlanda, Cecilia

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Differential involvement of α4β2, α7 and α9α10 nicotinic acetylcholine receptors in B lymphocyte activation in vitro by Koval, Lyudmyla, Lykhmus, Olena, Zhmak, Maxim, Khruschov, Alexey, Tsetlin, Victor, Magrini, Elena, Viola, Antonella, Chernyavsky, Alexander, Qian, Jing, Grando, Sergei, Komisarenko, Sergei, Skok, Maryna

“…Mouse B lymphocytes express several nicotinic acetylcholine receptor (nAChR) subtypes, their exact functions being not clearly understood. Here we show that α7…”
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The requirements for manufacturing highly active or sensitising drugs comparing Good Manufacturing Practices by Petrelli, Fabio, Caraffa, Alessandro, Scuri, Stefania, Grappasonni, Iolanda, Magrini, Elena, Cocchini, Aldo

“…To date there exist no internationally recognised Good Manufacturing Practices (GMP) that clearly outline universally accepted standards for manufacturing…”
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Serotonin-mediated tuning of human helper T cell responsiveness to the chemokine CXCL12 by Magrini, Elena, Szabò, Ildikò, Doni, Andrea, Cibella, Javier, Viola, Antonella

“…In addition to its role as neurotransmitter, serotonin (5-HT) is an important modulator of inflammation and immunity. Here, we report novel findings suggesting…”
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Microarray profiling of L1-overexpressing endothelial cells reveals STAT3 activation via IL-6/IL-6Rα axis by Magrini, Elena, Cavallaro, Ugo, Bianchi, Fabrizio

“…We recently identified a novel role for the L1 transmembrane glycoprotein (also known as L1CAM or CD171) in the regulation of tumor angiogenesis and vessels…”
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COVID-19 thromboinflammation: adding inflammatory fibrin to the puzzle by Magrini, Elena, Garlanda, Cecilia

“…Thromboinflammation is a peculiar and key component of acute COVID-19 pathogenesis, which contributes to long COVID. In a recent study, Ryu et al. demonstrate…”
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Noncanonical Functions of C1s Complement Its Canonical Functions in Renal Cancer by Magrini, Elena, Garlanda, Cecilia

“…Complement activation contributes to tumor progression in several cancer types. In this issue, Daugan and colleagues propose complement component C1s and C4d…”
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Complement activation in cancer: Effects on tumor-associated myeloid cells and immunosuppression by Magrini, Elena, Minute, Luna, Dambra, Monica, Garlanda, Cecilia

“…Cancer-related inflammation plays a central role in the establishment of tumor-promoting mechanisms. Tumor-associated myeloid cells, which engage in complex…”
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The pentraxins PTX3 and SAP in innate immunity, regulation of inflammation and tissue remodelling by Bottazzi, Barbara, Inforzato, Antonio, Messa, Massimo, Barbagallo, Marialuisa, Magrini, Elena, Garlanda, Cecilia, Mantovani, Alberto

“…Summary Pentraxins are a superfamily of fluid phase pattern recognition molecules conserved in evolution and characterized by a cyclic multimeric structure…”
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Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors by Ponzetta, Andrea, Carriero, Roberta, Carnevale, Silvia, Barbagallo, Marialuisa, Molgora, Martina, Perucchini, Chiara, Magrini, Elena, Gianni, Francesca, Kunderfranco, Paolo, Polentarutti, Nadia, Pasqualini, Fabio, Di Marco, Sabrina, Supino, Domenico, Peano, Clelia, Cananzi, Ferdinando, Colombo, Piergiuseppe, Pilotti, Silvana, Alomar, Suliman Yousef, Bonavita, Eduardo, Galdiero, Maria Rosaria, Garlanda, Cecilia, Mantovani, Alberto, Jaillon, Sebastien

“…Neutrophils are a component of the tumor microenvironment and have been predominantly associated with cancer progression. Using a genetic approach complemented…”
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The Yin Yang of Complement and Cancer by Meri, Seppo, Magrini, Elena, Mantovani, Alberto, Garlanda, Cecilia

“…Cancer-related inflammation is a crucial component of the tumor microenvironment (TME). Complement activation occurs in cancer and supports the development of…”
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