Search Results - "Eldrid, Charles"

Suppression of O‑Linked Glycosylation of the SARS-CoV‑2 Spike by Quaternary Structural Restraints by Eldrid, Charles F. S, Allen, Joel D, Newby, Maddy L, Crispin, Max

“…Understanding the glycosylation of the envelope spike (S) protein of SARS-CoV-2 is important in defining the antigenic surface of this key viral target…”
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Inhibition of the Staphylococcus aureus c-di-AMP cyclase DacA by direct interaction with the phosphoglucosamine mutase GlmM by Tosi, Tommaso, Hoshiga, Fumiya, Millership, Charlotte, Singh, Rahul, Eldrid, Charles, Patin, Delphine, Mengin-Lecreulx, Dominique, Thalassinos, Konstantinos, Freemont, Paul, Gründling, Angelika

“…c-di-AMP is an important second messenger molecule that plays a pivotal role in regulating fundamental cellular processes, including osmotic and cell wall…”
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VEGFA, B, C: Implications of the C-Terminal Sequence Variations for the Interaction with Neuropilins by Eldrid, Charles, Zloh, Mire, Fotinou, Constantina, Yelland, Tamas, Yu, Lefan, Mota, Filipa, Selwood, David L, Djordjevic, Snezana

“…Vascular endothelial growth factors (VEGFs) are the key regulators of blood and lymphatic vessels' formation and function. Each of the proteins from the…”
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Developments in tandem ion mobility mass spectrometry by Eldrid, Charles, Thalassinos, Konstantinos

“…Ion Mobility (IM) coupled to mass spectrometry (MS) is a useful tool for separating species of interest out of small quantities of heterogenous mixtures via a…”
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Concentration‐dependent coulombic effects in travelling wave ion mobility spectrometry collision cross section calibration by Eldrid, Charles, O'Connor, Eloise, Thalassinos, Konstantinos

“…Rationale Travelling wave ion mobility spectrometry (TWIMS) is increasingly being used as a method for calculating the collision cross sections (CCSs) of…”
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Gas Phase Stability of Protein Ions in a Cyclic Ion Mobility Spectrometry Traveling Wave Device by Eldrid, Charles, Ujma, Jakub, Kalfas, Symeon, Tomczyk, Nick, Giles, Kevin, Morris, Mike, Thalassinos, Konstantinos

“…Ion mobility mass spectrometry (IM-MS) allows separation of native protein ions into “conformational families”. Increasing the IM resolving power should allow…”
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Linking Gas-Phase and Solution-Phase Protein Unfolding via Mobile Proton Simulations by Eldrid, Charles, Cragnolini, Tristan, Ben-Younis, Aisha, Zou, Junjie, Raleigh, Daniel P., Thalassinos, Konstantinos

“…Native mass spectrometry coupled to ion mobility (IM-MS) combined with collisional activation (CA) of ions in the gas phase (in vacuo) is an important method…”
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Cyclic Ion Mobility–Collision Activation Experiments Elucidate Protein Behavior in the Gas Phase by Eldrid, Charles, Ben-Younis, Aisha, Ujma, Jakub, Britt, Hannah, Cragnolini, Tristan, Kalfas, Symeon, Cooper-Shepherd, Dale, Tomczyk, Nick, Giles, Kevin, Morris, Mike, Akter, Rehana, Raleigh, Daniel, Thalassinos, Konstantinos

“…Ion mobility coupled to mass spectrometry (IM-MS) is widely used to study protein dynamics and structure in the gas phase. Increasing the energy with which the…”
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Analysis of Proline Substitutions Reveals the Plasticity and Sequence Sensitivity of Human IAPP Amyloidogenicity and Toxicity by Ridgway, Zachary, Eldrid, Charles, Zhyvoloup, Alexander, Ben-Younis, Aisha, Noh, Daeun, Thalassinos, Konstantinos, Raleigh, Daniel P

“…Pancreatic amyloid formation by the polypeptide IAPP contributes to β-cell dysfunction in type 2 diabetes. There is a 1:1 correspondence between the ability of…”
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Analysis of Baboon IAPP Provides Insight into Amyloidogenicity and Cytotoxicity of Human IAPP by Ridgway, Zachary, Lee, Kyung-Hoon, Zhyvoloup, Alexander, Wong, Amy, Eldrid, Charles, Hannaberry, Eleni, Thalassinos, Konstantinos, Abedini, Andisheh, Raleigh, Daniel P.

“…The polypeptide hormone islet amyloid polypeptide (IAPP) forms islet amyloid in type 2 diabetes, a process which contributes to pancreatic β-cell dysfunction…”
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Gas Phase Stability and Unfolding of Proteins Via Ion Mobility-Mass Spectrometry by Eldrid, Charles

“…The study of protein dynamics and unfolding is key to understanding the basis of misfolding and aggregational diseases such as type II diabetes, α1-antrypsin…”
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The solution structure of the human IgG2 subclass is distinct from those for human IgG1 and IgG4 providing an explanation for their discrete functions by Hui, Gar Kay, Gardener, Antoni D., Begum, Halima, Eldrid, Charles, Thalassinos, Konstantinos, Gor, Jayesh, Perkins, Stephen J.

“…Human IgG2 antibody displays distinct therapeutically-useful properties compared with the IgG1, IgG3, and IgG4 antibody subclasses. IgG2 is the second most…”
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