Search Results - "Elder, R H"

The effect of Msh2 knockdown on methylating agent induced toxicity in DNA glycosylase deficient cells by Cooley, N, Elder, R.H, Povey, A.C

“…Abstract The DNA structure recognition protein MSH2 is an important protein in DNA mismatch repair due to its role in initiating the repair process. To examine…”
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Thermal imaging of solid oxide cells operating under electrolysis conditions by Cumming, D.J., Elder, R.H.

“…Solid oxide fuel cells remain at the forefront of research into electrochemical energy conversion technology. More recent interest has focused on operating in…”
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Levels of the DNA repair enzyme human apurinic/apyrimidinic endonuclease (APE1, APEX, Ref-1) are associated with the intrinsic radiosensitivity of cervical cancers by HERRING, C. J, WEST, C. M. L, HENDRY, J. H, MARGISON, G. P, WILKS, D. P, DAVIDSON, S. E, HUNTER, R. D, BERRY, P, FORSTER, G, MACKINNON, J, RAFFERTY, J. A, ELDER, R. H

“…A study was made of the relationship between the intrinsic radiosensitivity of human cervical tumours and the expression of the DNA repair enzyme human…”
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Dietary Fish Oil Reduces O6-Methylguanine DNA Adduct Levels in Rat Colon in Part by Increasing Apoptosis during Tumor Initiation by MEE YOUNG HONG, LUPTON, J. R, MORRIS, J. S, NAISYIN WANG, CARROLL, R. J, DAVIDSON, L. A, ELDER, R. H, CHAPKIN, R. S

“…There is epidemiological, clinical, and experimental evidence that dietary fish oil, containing n-3 polyunsaturated fatty acids, protects against colon tumor…”
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Increased Susceptibility to Streptozotocin-Induced β-Cell Apoptosis and Delayed Autoimmune Diabetes in Alkylpurine- DNA-N-Glycosylase-Deficient Mice by Cardinal, John W., Margison, Geoffrey P., Mynett, Kurt J., Yates, Allen P., Cameron, Donald P., Elder, Rhoderick H.

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The Effect of Msh2 Knockdown on Toxicity Induced by tert-Butyl-hydroperoxide, Potassium Bromate, and Hydrogen Peroxide in Base Excision Repair Proficient and Deficient Cells by Cooley, N., Povey, A. C., Elder, R. H.

“…The DNA mismatch repair (MMR) and base excision repair (BER) systems are important determinants of cellular toxicity following exposure to agents that cause…”
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The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway by Gros, Laurent, Ishchenko, Alexander A., Ide, Hiroshi, Elder, Rhoderick H., Saparbaev, Murat K.

“…In nucleotide incision repair (NIR), an endonuclease nicks oxidatively damaged DNA in a DNA glycosylase‐independent manner, providing the correct ends for DNA…”
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Changes in the expression of cytochrome P450 isozymes and related carcinogen metabolizing enzyme activities in Schistosoma mansoni-infected mice by Sheweita, S A, Mubark, J, Doenhofe, M J, Mostafa, M H, Margison, G P, O'Connor, P J, Elder, R H

“…Mixed-function oxidase enzymes metabolize most xenobiotic agents. Western blotting was used to investigate the effect of Schistosoma mansoni infection on the…”
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Expression levels of the DNA repair enzyme HAP1 do not correlate with the radiosensitivities of human or HAP1-transfected rat cell lines by HERRING, C, DEANS, B, ELDER, R, RAFFERTY, J, MACKINNON, J, BARZILAY, G, HICKSON, I, HENDRY, J, MARGISON, G

“…Apurinic/apyrimidinic (AP) sites in DNA are potentially lethal and mutagenic. They can arise spontaneously or following DNA damage from reactive oxygen species…”
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Targeted Deletion of Alkylpurine-DNA-N-Glycosylase in Mice Eliminates Repair of 1,N6-ethenoadenine and Hypoxanthine but not of 3,N4-ethenocytosine or 8-oxoguanine by Hang, B., Singer, B., Margison, G. P., Hlder, R. H.

“…It has previously been reported that 1,N6-ethenoadenine (ε A), deaminated adenine (hypoxanthine, Hx), and 7,8-dihydro-8-oxoguanine (8-oxoG), but not…”
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A molecular beacon assay for measuring base excision repair activities by Maksimenko, Andrei, Ishchenko, Alexander A, Sanz, Guenhaël, Laval, Jacques, Elder, Rhoderick H, Saparbaev, Murat K

“…The base excision repair (BER) pathway plays a key role in protecting the genome from endogenous DNA damage. Current methods to measure BER activities are…”
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DNA repair : Kinetics and thresholds by O'CONNOR, P. J, MANNING, F. C. R, GORDON, A. T, BILLETT, M. A, COOPER, D. P, ELDER, R. H, MARGISON, G. P

“…DNA damage is a critical factor in the initiation of chemically induced toxicities (including cancer), and the repair of this damage represents the cell's…”
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Targeted deletion of alkylpurine-DNA-N-glycosylase in mice eliminates repair of 1, N 6 -ethenoadenine and hypoxanthine but not of 3, N 4 -ethenocytosine or 8-oxoguanine by Hang, B., Singer, B., Margison, G. P., Elder, R. H.

“…It has previously been reported that 1, N 6 -ethenoadenine (ɛA), deaminated adenine (hypoxanthine, Hx), and 7,8-dihydro-8-oxoguanine (8-oxoG), but not 3, N 4…”
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DNA N-glycosylase deficient mice: a tale of redundancy by Parsons, Jason L, Elder, Rhoderick H

“…The generation of mouse models of base excision repair deficiency has resulted in a re-examination of the cellular defence mechanisms that exist to counteract…”
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Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bone marrow transplantation by LEE, S. M, CROWTHER, D, SCARFFE, J. H, DOUGAL, M, ELDER, R. H, RAFFERTY, J. A, MARGISON, G. P

“…O6-alkylguanine-DNA-alkyltransferase (ATase) levels were measured in extracts of peripheral blood lymphocytes taken at various times during chemotherapy from…”
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Compromised Incision of Oxidized Pyrimidines in Liver Mitochondria of Mice Deficient in NTH1 and OGG1 Glycosylases by Karahalil, Bensu, de Souza-Pinto, Nadja C., Parsons, Jason L., Elder, Rhoderick H., Bohr, Vilhelm A.

“…Mitochondrial DNA is constantly exposed to high levels of endogenously produced reactive oxygen species, resulting in elevated levels of oxidative damaged DNA…”
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Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate by Elder, Rhoderick H., Jansen, Jacob G., Weeks, Robert J., Willington, Mark A., Deans, Bryan, Watson, Amanda J., Mynett, Kurt J., Bailey, John A., Cooper, Donald P., Rafferty, Joseph A., Heeran, Mel C., Wijnhoven, Susan W. P., van Zeeland, Albert A., Margison, Geoffrey P.

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C-terminally truncated human O6-alkylguanine-DNA alkyltransferase retains activity by ELDER, R. H, TUMELTY, J, DOUGLAS, K. T, MARGISON, G. P, RAFFERTY, J. A

“…A cDNA encoding the human O6-alkylguanine-DNA alkyltransferase (ATase; EC 2.1.1.63; methylated-DNA: protein-cysteine methyltransferase) has been manipulated to…”
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The Separation of Hix in the Sulphur–Iodine Thermochemical Cycle for Sustainable Hydrogen Production by Elder, R.H., Priestman, G.H., Ewan, B.C., Allen, R.W.K.

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Immunohistological examination of the inter- and intracellular distribution of O6-alkylguanine DNA-alkyltransferase in human liver and melanoma by Lee, S M, Rafferty, J A, Elder, R H, Fan, C Y, Bromley, M, Harris, M, Thatcher, N, Potter, P M, Altermatt, H J, Perinat-Frey, T

“…The tissue and cellular distribution of the DNA repair protein O6-alkylguanine-DNA-alkyltransferase (ATase) is an important question in relation to the…”
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