Search Results - "Elder, J. Bradley"

Gene therapy for aromatic L-amino acid decarboxylase deficiency by MR-guided direct delivery of AAV2-AADC to midbrain dopaminergic neurons by Pearson, Toni S., Gupta, Nalin, San Sebastian, Waldy, Imamura-Ching, Jill, Viehoever, Amy, Grijalvo-Perez, Ana, Fay, Alex J., Seth, Neha, Lundy, Shannon M., Seo, Youngho, Pampaloni, Miguel, Hyland, Keith, Smith, Erin, de Oliveira Barbosa, Gardenia, Heathcock, Jill C., Minnema, Amy, Lonser, Russell, Elder, J. Bradley, Leonard, Jeffrey, Larson, Paul, Bankiewicz, Krystof S.

“…Aromatic L-amino acid decarboxylase (AADC) deficiency is a rare genetic disorder characterized by deficient synthesis of dopamine and serotonin. It presents in…”
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Congress of Neurological Surgeons Systematic Review and Evidence-Based Guidelines on the Role of Emerging and Investigational Therapties for the Treatment of Adults With Metastatic Brain Tumors by Elder, J Bradley, Nahed, Brian V, Linskey, Mark E, Olson, Jeffrey J

“…Abstract QUESTION What evidence is available regarding emerging and investigational treatment options for metastatic brain tumors? TARGET POPULATION Adult…”
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A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases by Chen, Xilin, Han, Jianfeng, Chu, Jianhong, Zhang, Lingling, Zhang, Jianying, Chen, Charlie, Chen, Luxi, Wang, Youwei, Wang, Hongwei, Yi, Long, Elder, J Bradley, Wang, Qi-En, He, Xiaoming, Kaur, Balveen, Chiocca, E Antonio, Yu, Jianhua

“…Breast cancer brain metastases (BCBMs) are common in patients with metastatic breast cancer and indicate a poor prognosis. These tumors are especially…”
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Real-time magnetic resonance imaging-guided frameless stereotactic brain biopsy: technical note by Mohyeldin, Ahmed, Lonser, Russell R, Elder, J Bradley

“…The object of this study was to assess the feasibility, accuracy, and safety of real-time MRI-compatible frameless stereotactic brain biopsy. Clinical,…”
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Genetic analysis of a malignant meningioma and associated metastases by Huntoon, Kristin, Yilmaz, Ayse Selen, Pietrzak, Maciej, Chen, Xi, Yan, Pearlly, Toland, Amanda Ewart, Elder, J. Bradley

“…To identify genes altered in a highly aggressive metastatic meningioma primary as well as its metastases. Exome sequencing of a primary anaplastic meningioma…”
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Intraoperative 3 T MRI is more correlative to residual disease extent than early postoperative MRI by Huntoon, Kristin, Makary, Mina S., Damante, Mark, Giglio, Pierre, Slone, Wayne, Elder, J. Bradley

“…Purpose Extent of resection of low grade glioma (LGG) is an important prognostic variable, and may influence decisions regarding adjuvant therapy in certain…”
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Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma by Cloughesy, Timothy F, Landolfi, Joseph, Hogan, Daniel J, Bloomfield, Stephen, Carter, Bob, Chen, Clark C, Elder, J Bradley, Kalkanis, Steven N, Kesari, Santosh, Lai, Albert, Lee, Ian Y, Liau, Linda M, Mikkelsen, Tom, Nghiemphu, Phioanh Leia, Piccioni, David, Walbert, Tobias, Chu, Alice, Das, Asha, Diago, Oscar R, Gammon, Dawn, Gruber, Harry E, Hanna, Michelle, Jolly, Douglas J, Kasahara, Noriyuki, McCarthy, David, Mitchell, Leah, Ostertag, Derek, Robbins, Joan M, Rodriguez-Aguirre, Maria, Vogelbaum, Michael A

“…Toca 511 (vocimagene amiretrorepvec) is an investigational nonlytic, retroviral replicating vector (RRV) that delivers a yeast cytosine deaminase, which…”
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Phase I trial of intracerebral convection-enhanced delivery of carboplatin for treatment of recurrent high-grade gliomas by Wang, Joshua L, Barth, Rolf F, Cavaliere, Robert, Puduvalli, Vinay K, Giglio, Pierre, Lonser, Russell R, Elder, J Bradley

“…Carboplatin is a potent cytoreductive agent for a variety of solid tumors. However, when delivered systemically, clinical efficacy for the treatment of high…”
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Trends in central nervous system tumor incidence relative to other common cancers in adults, adolescents, and children in the United States, 2000 to 2010 by Gittleman, Haley R., Ostrom, Quinn T., Rouse, Chaturia D., Dowling, Jacqueline A., de Blank, Peter M., Kruchko, Carol A., Elder, J. Bradley, Rosenfeld, Steven S., Selman, Warren R., Sloan, Andrew E., Barnholtz‐Sloan, Jill S.

“…BACKGROUND Time trends in cancer incidence rates (IR) are important to measure the changing burden of cancer on a population over time. The overall IR of…”
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Neurosurgical involvement in clinical trials for CNS tumors by Vogelbaum, Michael A., Parney, Ian F., Elder, J. Bradley, Cahill, Daniel

“…Introduction Most clinical trials in neurooncology are led by investigators primarily trained in neurology or medical oncology. While neurosurgeons are trained…”
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Histologic findings associated with laser interstitial thermotherapy for glioblastoma multiforme by Elder, J Bradley, Huntoon, Kristin, Otero, Jose, Kaya, Behiye, Hatef, Jeff, Eltobgy, Mostafa, Lonser, Russell R

“…Laser-interstitial thermal therapy (LITT) has been supported by some authors as an ablative treatment of glioblastoma multiforme (GBM). Although the effects of…”
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Surgical Management of Recurrent Brain Metastasis: A Systematic Review of Laser Interstitial Thermal Therapy by Damante, Mark A, Wang, Joshua L, Elder, J. Bradley

“…The incidence of recurrent metastatic brain tumors is increasing due to advances in local therapy, including surgical and radiosurgical management, as well as…”
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Impact of cerebrospinal fluid flow study in patients undergoing intrathecal chemotherapy via ventricular catheter reservoir by Eltobgy, Mostafa, Huntoon, Kristin, Musgrave, Nick, Shaikhouni, Ammar, Hardesty, Douglas A., Giglio, Pierre, Elder, J. Bradley

“…Purpose Leptomeningeal carcinomatosis (LMC) is a form of CNS cancer metastasis with severe morbidity. Intrathecal chemotherapy (ITC) administration through an…”
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Biological and clinical impact of hemangioblastoma-associated peritumoral cysts in von Hippel-Lindau disease by Huntoon, Kristin, Wu, Tianxia, Elder, J Bradley, Butman, John A, Chew, Emily Y, Linehan, W Marston, Oldfield, Edward H, Lonser, Russell R

“…Peritumoral cysts are frequently associated with CNS hemangioblastomas and often underlie neurological morbidity and mortality. To determine their natural…”
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Activation of hypoxia signaling induces phenotypic transformation of glioma cells: implications for bevacizumab antiangiogenic therapy by Xu, Hui, Rahimpour, Shervin, Nesvick, Cody L, Zhang, Xu, Ma, Jingyun, Zhang, Min, Zhang, Ge, Wang, Li, Yang, Chunzhang, Hong, Christopher S, Germanwala, Anand V, Elder, J Bradley, Ray-Chaudhury, Abhik, Yao, Yu, Gilbert, Mark R, Lonser, Russell R, Heiss, John D, Brady, Roscoe O, Mao, Ying, Qin, Jianhua, Zhuang, Zhengping

“…Glioblastoma (GBM) is the most common and deadly primary brain tumor in adults. Bevacizumab, a humanized monoclonal antibody against vascular endothelial…”
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An Update on Gene Therapy Approaches for Parkinson's Disease: Restoration of Dopaminergic Function by Van Laar, Amber D, Van Laar, Victor S, San Sebastian, Waldy, Merola, Aristide, Elder, J Bradley, Lonser, Russell R, Bankiewicz, Krystof S

“…At present there is a significant unmet need for clinically available treatments for Parkinson's disease (PD) patients to stably restore balance to dopamine…”
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A Novel Craniotomy Simulator Provides a Validated Method to Enhance Education in the Management of Traumatic Brain Injury by Lobel, Darlene A., Elder, J. Bradley, Schirmer, Clemens M., Bowyer, Mark W., Rezai, Ali R.

“…BACKGROUND:In a variety of surgical specialties, simulation-based technologies play an important role in resident training. The Congress of Neurological…”
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Implementation of triggered kilovoltage imaging for stereotactic radiotherapy of the spine for patients with spinal fixation hardware by Cetnar, Ashley J., Degnan, Michael, Pichler, Joseph, Jain, Sagarika, Morelli, Samantha, Thomas, Evan, Elder, J. Bradley, Scharschmidt, Thomas J., Palmer, Joshua D., Blakaj, Dukagjin M.

“…•Triggered imaging is an effective method of assessing intrafraction motion for stereotactic spine patients with hardware.•The technology provides the ability…”
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In Reply: Simulating Ventriculostomy by Lobel, Darlene A, Schirmer, Clemens M, Elder, J Bradley, Roitberg, Ben

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International Differences in Treatment and Clinical Outcomes for High Grade Glioma by Chien, Li-Nien, Ostrom, Quinn T, Gittleman, Haley, Lin, Jia-Wei, Sloan, Andrew E, Barnett, Gene H, Elder, J Bradley, McPherson, Christopher, Warnick, Ronald, Chiang, Yung-Hsiao, Lin, Chieh-Min, Rogers, Lisa R, Chiou, Hung-Yi, Barnholtz-Sloan, Jill S

“…High grade gliomas are the most common type of malignant brain tumor, and despite their rarity, cause significant morbidity and mortality. This study aimed to…”
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