Search Results - "Eldefrawi, A.T."

Toxicity of sea nettle toxin to human hepatocytes and the protective effects of phosphorylating and alkylating agents by Cao, C.J, Eldefrawi, M.E, Eldefrawi, A.T, Burnett, J.W, Mioduszewski, R.J, Menking, D.E, Valdes, J.J

“…The sea nettle jellyfish toxin (SNTX), which contains several polypeptides, was highly toxic to human hepatocytes. The Cytosensor microphysiometer was used…”
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Fiber optic immunosensor for polychlorinated biphenyls by Zhao, Christopher Q, Anis, Nabil A, Rogers, Kim R, Kline, Richard H, Wright, Jeremy, Eldefrawi, Amira T, Eldefrawi, Mohyee E

“…A fiber optic immunosensor, consisting of a quartz fiber coated with partially purified polyclonal anti-PCB antibodies (Abs), was used to detect…”
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Chlorpyrifos, Parathion, and Their Oxons Bind to and Desensitize a Nicotinic Acetylcholine Receptor: Relevance to Their Toxicities by Katz, Elizabeth J., Cortes, Vania I., Eldefrawi, Mohyee E., Eldefrawi, Amira T.

“…The nicotinic acetylcholine receptor (nAChR) of the electric organ of the electric ray.Torpedosp., the richest source of nAChR, with similar structure and…”
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Allethrin interactions with the nicotinic acetylcholine receptor channel by Abbassy, M A, Eldefrawi, M E, Eldefrawi, A T

“…Interactions of the synthetic pyrethroid allethrin with the nicotinic acetylcholine (ACh) receptor/channel were studied in membranes from Torpedo electric…”
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Structure and synthesis of a potent glutamate receptor antagonist in wasp venom by Eldefrawi, A.T, Eldefrawi, M.E, Konno, K, Mansour, N.A, Nakanishi, K, Oltz, E, Usherwood, P.N.R

“…A low molecular weight toxin isolated from the venom of the digger wasp Philanthus triangulum, first noted by T. Piek, is a potent antagonist of transmission…”
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A Fiber-Optic Cocaine Biosensor by Devine, P.J., Anis, N.A., Wright, J., Kim, S., Eldefrawi, A.T., Eldefrawi, M.E.

“…A fiber-optic biosensor was developed for detection of cocaine, its metabolites, and other coca alkaloids, using a monoclonal antibody (mAb) against a…”
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Cytotoxicity of organophosphate anticholinesterases to human liver and nerve cells by Mioduszewski, R.J., Menking, D.E., Valdes, J.J., Cao, C.J., Eldefrawi, M.E., Eldefrawi, A.T.

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Putative M2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases by Silveira, C L, Eldefrawi, A T, Eldefrawi, M E

“…The M2 subtype of muscarinic receptor is predominant in heart, and such receptors were reported to be located in muscles as well as in presynaptic cholinergic…”
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Rapid detection of anticholinesterase insecticides by a reusable light addressable potentiometric biosensor by Fernando, John C, Rogers, Kim R, Anis, Nabil A, Valdes, James J, Thompson, Roy G, Eldefrawi, Amira T, Eldefrawi, Mohyee E

“…A light addressable potentiometric sensor (LAPS) was used to detect organophosphate and carbamate anticholinesterases (anti-ChEs), using eel…”
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Cyclodiene insecticides inhibit GABAA receptor-regulated chloride transport by Gant, D B, Eldefrawi, M E, Eldefrawi, A T

“…The function of GABAA receptors in rat brain was assayed by GABA stimulation of 36Cl-influx into membrane microsacs. The evidence that the measured flux…”
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Differential regulation of muscarinic receptor subtypes in rat brain regions by repeated injections of parathion by Jett, D A, Fernando, J C, Eldefrawi, M E, Eldefrawi, A T

“…Repeated injections with increasing moderate doses of parathion into adult male rats for 21 days resulted in 84-90% inhibition of acetylcholinesterase in the…”
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Validation of the cytosensor for in vitro cytotoxicity studies by Cao, C.J., Mioduszewski, R.J., Menking, D.E., Valdes, J.J., Cortes, V.I., Eldefrawi, M.E., Eldefrawi, A.T.

“…The Cytosensor ™ microphysiometer was used to continuously monitor perturbations in metabolic rates of the human liver cell line ATCC-CCL-13 when exposed to…”
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Actions of the insecticide 2(nitromethylene)tetrahydro-1,3-thiazine on insect and vertebrate nicotinic acetylcholine receptors by Sattelle, David B., Buckingham, Steven D., Wafford, K. A., Sherby, S. M., Bakry, N. M., Eldefrawi, A. T., Eldefrawi, M. E., May, T. E.

“…The nitromethylene heterocyclic compound 2(nitromethylene)tetrahydro) 1, 3-thiazine (NMTHT) inhibits the binding of [125I)α-bungarotoxin to membranes prepared…”
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Structure-activity relationships of analogues of the wasp toxin philanthotoxin: non-competitive antagonists of quisqualate receptors by Bruce, M, Bukownik, R, Eldefrawi, A T, Eldefrawi, M E, Goodnow, Jr, R, Kallimopoulos, T, Konno, K, Nakanishi, K, Niwa, M, Usherwood, P N

“…Fifty-two analogues of the wasp toxin, philanthotoxin-433, have been synthesized and tested on a glutamatergic, nerve-muscle preparation from locust leg…”
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Action of polychlorocycloalkane insecticides on binding of [35S]t-butylbicyclophosphorothionate to Torpedo electric organ membranes and stereospecificity of the binding site by Matsumoto, K, Eldefrawi, M E, Eldefrawi, A T

“…Binding of [35S]t-butylbicyclophosphorothionate ([35S]TBPS) to Torpedo electric organ membranes was characterized. A dose- and pH-dependent binding (100.8…”
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Synthesis and binding of [125I2]philanthotoxin-343, [125I2]philanthotoxin-343-lysine, and [125I2]philanthotoxin-343-arginine to rat brain membranes by Goodnow, R. A, Bukownik, R, Nakanishi, K, Usherwood, P. N. R, Eldefrawi, A. T, Anis, N. A, Eldefrawi, M. E

“…125I2-iodinated philanthotoxin-343 (PhTX-343), [125I2]PhTX-343-arginine, and [125I2]PhTX-343-lysine were synthesized and evaluated as probes for glutamate…”
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ATP-regulated neuronal catecholamine uptake: a new mechanism by Cao, C J, Eldefrawi, A T, Eldefrawi, M E

“…Uptake of the catecholamines (CA), dopamine (DA) and norepinephrine (NE) into synaptosomes prepared from rat and bovine brains was potentiated by ATP (from 0.1…”
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Glutamate receptor inhibitors as potential insecticides by Eldefrawi, M E, Anis, N A, Eldefrawi, A T

“…Philanthotoxin (PhTX) is a neurotoxic constituent of the paralytic venom of the digger wasp, Philanthus triangulum. PhTX inhibits glutamate receptors of insect…”
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Regulation of [3H]perhydrohistrionicotoxin binding to Torpedo ocellata electroplax by effectors of the acetylcholine receptor by Aronstam, R S, Eldefrawi, A T, Pessah, I N, Daly, J W, Albuquerque, E X, Eldefrawi, M E

“…The specific binding of [3H]perhydrohistrionicotoxin ([3H]H12-HTX) to the ionic channel of the nicotinic receptor in membranes from the electric organ of the…”
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Effects of insecticides on GABA-induced chloride influx into rat brain microsacs by Abalis, I M, Eldefrawi, M E, Eldefrawi, A T

“…The actions of different insecticides known to affect binding of ligands to gamma-aminobutyric acid (GABA) receptors were studied on the function of GABAA…”
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