Predictability of Vitreous Detachment Following Intravitreal Plasmin Injection in Diabetic Macular Edema Associated with Vitreomacular Traction

Purpose: To assess preoperative factors associated with postoperative posterior vitreous detachment (PVD) following intravitreal autologous plasmin injection in diabetic macular edema associated with vitreomacular traction. Methods: Twenty-five eyes with diabetic macular edema associated with vitreo...

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Bibliographic Details
Published in:	Current eye research Vol. 36; no. 6; pp. 534 - 539
Main Authors:	Elbendary, Amal M., Elwan, Mohamed M., Azzam, Hanan A., Eldeeb, Doaa R.
Format:	Journal Article
Language:	English
Published:	England Informa Healthcare 01-06-2011 Taylor & Francis
Subjects:	Adult Aged Autologous Diabetic macular edema Diabetic Retinopathy - complications Diabetic Retinopathy - diagnosis Diabetic Retinopathy - drug therapy Egypt - epidemiology Female Fibrinolysin - administration & dosage Fibrinolysin - adverse effects Fibrinolytic Agents - administration & dosage Fibrinolytic Agents - adverse effects Follow-Up Studies Humans Incidence Intravitreal injection Intravitreal Injections Macular Edema - complications Macular Edema - diagnosis Macular Edema - drug therapy Male Middle Aged Plasmin Prognosis Prospective Studies Retinal Detachment - complications Retinal Detachment - diagnosis Retinal Detachment - surgery Time Factors Tomography, Optical Coherence Vitrectomy Vitreomacular traction Vitreous Detachment - chemically induced Vitreous Detachment - diagnosis Vitreous Detachment - epidemiology Egypt
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Summary:	Purpose: To assess preoperative factors associated with postoperative posterior vitreous detachment (PVD) following intravitreal autologous plasmin injection in diabetic macular edema associated with vitreomacular traction. Methods: Twenty-five eyes with diabetic macular edema associated with vitreomacular traction as documented with optical coherence tomography were included. Approximately 0.2 IU/0.2 ml of autologous plasmin was injected intravitreally. Condition of the posterior vitreous face (degree of detachment, thickness, reflectivity, and diameter of attached vitreous base) was evaluated preoperatively and postoperatively up to 3 months. Results: PVD was achieved in ten eyes (41.7%). There was a significant difference (P = 0.03) in mean posterior vitreous face thickness between the eyes with PVD and the eyes with failed PVD. There was a significant correlation between PVD and both posterior vitreous face thickness (P < 0.03%) and degree of posterior vitreous face reflectivity (P = 0.002). Conclusion: In diabetic eyes with vitreomacular traction, the prediction of PVD after plasmin injection is governed by the condition of posterior vitreous face; mainly posterior vitreous face thickness and reflectivity. Eyes with thinner, less reflective posterior vitreous face are more likely to develop PVD.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	0271-3683 1460-2202
DOI:	10.3109/02713683.2011.569868