Bio-Based Photoreversible Networks Containing Coumarin Groups for Future Medical Applications

Photocurable biomaterials that can be delivered as liquids and rapidly (within seconds) cured in situ using UV light are gaining increased interest in advanced medical applications. Nowadays, fabrication of biomaterials that contain organic photosensitive compounds have become popular due to their s...

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Bibliographic Details
Published in:	Polymers Vol. 15; no. 8; p. 1885
Main Authors:	Elchiev, Iskenderbek, Demirci, Gokhan, El Fray, Miroslawa
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-04-2023 MDPI
Subjects:	Biological products Biomedical materials Caustic soda Chloride Communication Coumarin Coumarins Crosslinked polymers Crosslinking dimer fatty diol Dimers dynamic polymer networks Ethanol Fatty acids Hydrochloric acid Hydrogels Light Light irradiation NMR Nuclear magnetic resonance photocrosslinking Photosensitivity Polymers Potash Potassium Stimuli Technology application Tissue engineering Ultraviolet radiation Poland Germany United States > US photocrosslinking dimer fatty diol coumarin dynamic polymer networks
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Summary:	Photocurable biomaterials that can be delivered as liquids and rapidly (within seconds) cured in situ using UV light are gaining increased interest in advanced medical applications. Nowadays, fabrication of biomaterials that contain organic photosensitive compounds have become popular due to their self-crosslinking and versatile abilities of changing shape or dissolving upon external stimuli. Special attention is paid to coumarin due to its excellent photo- and thermoreactivity upon UV light irradiation. Thus, by modifying the structure of coumarin to make it reactive with a bio-based fatty acid dimer derivative, we specifically designed a dynamic network that is sensitive to UV light and able to both crosslink and re-crosslink upon variable wave lengths. A simple condensation reaction was applied to obtain future biomaterial suitable for injection and photocrosslinking in situ upon UV light exposure and decrosslinking at the same external stimuli but at different wave lengths. Thus, we performed the modification of 7-hydroxycoumarin and condensation with fatty acid dimer derivatives towards a photoreversible bio-based network for future medical applications.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2073-4360 2073-4360
DOI:	10.3390/polym15081885