Search Results - "Elborn, J. S"

Community dynamics and the lower airway microbiota in stable chronic obstructive pulmonary disease, smokers and healthy non-smokers by Einarsson, G G, Comer, D M, McIlreavey, L, Parkhill, J, Ennis, M, Tunney, M M, Elborn, J S

“…The role bacteria play in the progression of COPD has increasingly been highlighted in recent years. However, the microbial community complexity in the lower…”
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Neutrophils in cystic fibrosis by Downey, D G, Bell, S C, Elborn, J S

“…Lung injury in cystic fibrosis is caused by recurrent airway infection and inflammation. Neutrophils are important in combating these infections but are also…”
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Obesity and the lung: 1. Epidemiology by McClean, K M, Kee, F, Young, I S, Elborn, J S

“…Obesity is the most common metabolic disease in the world and its prevalence has been increasing over several decades. The World Health Organization (WHO)…”
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Use of culture and molecular analysis to determine the effect of antibiotic treatment on microbial community diversity and abundance during exacerbation in patients with cystic fibrosis by Tunney, M M, Klem, E R, Fodor, A A, Gilpin, D F, Moriarty, T F, McGrath, S J, Muhlebach, M S, Boucher, R C, Cardwell, C, Doering, G, Elborn, J S, Wolfgang, M C

“…Anaerobic bacteria are increasingly regarded as important in cystic fibrosis (CF) pulmonary infection. The aim of this study was to determine the effect of…”
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Exacerbations in cystic fibrosis: 3--Management by Smyth, A, Elborn, J S

“…Exacerbations of pulmonary symptoms in patients with cystic fibrosis must be recognised early and treated vigorously in order to maintain pulmonary function…”
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Phase I Studies of Acebilustat: Biomarker Response and Safety in Patients with Cystic Fibrosis by Elborn, JS, Horsley, A, MacGregor, G, Bilton, D, Grosswald, R, Ahuja, S, Springman, EB

“…There is a significant unmet need for safe and effective anti‐inflammatory treatment for cystic fibrosis. The aim of this study was to evaluate the safety of…”
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Phase I Studies of Acebilustat: Pharmacokinetics, Pharmacodynamics, Food Effect, and CYP3A Induction by Elborn, JS, Bhatt, L, Grosswald, R, Ahuja, S, Springman, EB

“…Acebilustat is a new once‐daily oral antiinflammatory drug in development for treatment of cystic fibrosis (CF) and other diseases. It is an inhibitor of…”
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A secretory leukocyte protease inhibitor variant with improved activity against lung infection by Camper, N, Glasgow, A M A, Osbourn, M, Quinn, D J, Small, D M, McLean, D T, Lundy, F T, Elborn, J S, McNally, P, Ingram, R J, Weldon, S, Taggart, C C

“…Secretory leukocyte protease inhibitor (SLPI) is an important respiratory tract host defense protein, which is proteolytically inactivated by excessive…”
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Quality control for multiple breath washout tests in multicentre bronchiectasis studies: Experiences from the BRONCH-UK clinimetrics study by O'Neill, Katherine, Lakshmipathy, Gokul R., Ferguson, Kathryn, Cosgrove, Denise, Hill, A.T., Loebinger, Michael R., Carroll, Mary, Chalmers, J.D., Gatheral, Timothy, Johnson, Chris, DeSoyza, Anthony, Hurst, John R., Bradbury, Ian, Elborn, J.S., Bradley, Judy M.

“…Multiple Breath Washout (MBW) to measure Lung Clearance Index (LCI) is increasingly being used as a secondary endpoint in multicentre bronchiectasis studies…”
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Modulation, microbiota and inflammation in the adult CF gut: A prospective study by Ronan, NJ, Einarsson, GG, Deane, J, Fouhy, F, Rea, M, Hill, C, Shanahan, F, Elborn, JS, Ross, RP, McCarthy, M, Murphy, DM, Eustace, JA, MM, Tunney, Stanton, C, Plant, BJ

“…•Ivacaftor does not produce significant change in gut microbiota in an adult cohort.•Ivacaftor treatment does not significantly alter gut inflammation in…”
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Predictors of mortality in adults with cystic fibrosis by Courtney, J.M., Bradley, J., Mccaughan, J., O'connor, T.M., Shortt, C., Bredin, C.P., Bradbury, I., Elborn, J.S.

“…Assessment of prognostic indicators in patients with cystic fibrosis (CF) is important. The study's aim was to assess the relative contribution of gender,…”
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Newer antibacterial agents and their potential role in cystic fibrosis pulmonary exacerbation management by Parkins, M. D., Elborn, J. S.

“…Pulmonary exacerbations in cystic fibrosis (CF) are frequent events and account for a substantial proportion of the burden of morbidity and mortality in this…”
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Consensus on the use and interpretation of cystic fibrosis mutation analysis in clinical practice by Castellani, C, Cuppens, H, Macek, M, Cassiman, J.J, Kerem, E, Durie, P, Tullis, E, Assael, B.M, Bombieri, C, Brown, A, Casals, T, Claustres, M, Cutting, G.R, Dequeker, E, Dodge, J, Doull, I, Farrell, P, Ferec, C, Girodon, E, Johannesson, M, Kerem, B, Knowles, M, Munck, A, Pignatti, P.F, Radojkovic, D, Rizzotti, P, Schwarz, M, Stuhrmann, M, Tzetis, M, Zielenski, J, Elborn, J.S

“…Abstract It is often challenging for the clinician interested in cystic fibrosis (CF) to interpret molecular genetic results, and to integrate them in the…”
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Proposed definitions of community-associated meticillin-resistant Staphylococcus aureus (CA-MRSA) by Millar, B.C, Loughrey, A, Elborn, J.S, Moore, J.E

“…Summary A new type of meticillin-resistant Staphylococcus aureus (MRSA) is emerging as a significant pathogen in otherwise healthy individuals in the…”
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Neutrophil cell death, activation and bacterial infection in cystic fibrosis by Watt, A P, Courtney, J, Moore, J, Ennis, M, Elborn, J S

“…Background: Cystic fibrosis (CF) is characterised by chronic endobronchial bacterial infection and neutrophil mediated inflammation. Neutrophil apoptosis is…”
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Association of airway cathepsin B and S with inflammation in cystic fibrosis by Martin, S.L., Moffitt, K.L., McDowell, A., Greenan, C., Bright-Thomas, R.J., Jones, A.M., Webb, A.K., Elborn, J.S.

“…Irreversible tissue damage within the cystic fibrosis (CF) lung is mediated by proteolytic enzymes during an inflammatory response. Serine proteinases, in…”
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Practical Guidelines: Lung Transplantation in Patients with Cystic Fibrosis by Wagner, T. O. F., ECORN-CF Study Group, T. O. F., Hogardt, M., Ellemunter, H., Elborn, J. S., Solé, A., Shimmin, D., Hebestreit, Helge, Knoop, C., Hirche, Tim Oliver, Aurora, P.

“…This paper is dedicated to Gerd Döring, who was a great researcher and scientist. He was also an enthusiastic participant of the CF Winter School in…”
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Neutrophil apoptosis, proinflammatory mediators and cell counts in bronchiectasis by Watt, A P, Brown, V, Courtney, J, Kelly, M, Garske, L, Elborn, J S, Ennis, M

“…Background: Lower airway secretions from patients with bronchiectasis show inflammatory cell infiltration and increased proinflammatory mediators. The aim of…”
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Aquagenic wrinkling of the palms in an adult cystic fibrosis population by Tolland, J P, Boyle, J, Hall, V, McKenna, K E, Elborn, J S

“…Aquagenic wrinkling of the palms (AWP) is a rare condition characterised by the development of oedema and excessive wrinkling of the palms following exposure…”
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“CF asthma”: what is it and what do we do about it? by Balfour-Lynn, I M, Elborn, J S

“…The diagnosis of “CF asthma” is problematic and it is difficult to determine which patients have a combination of CF and asthma and which have asthma like…”
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