Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

Effect of Cyclosporine on Reperfusion Injury in Acute Myocardial Infarction

Experimental evidence suggests that cyclosporine may attenuate myocardial reperfusion injury. In a pilot trial, 58 patients with acute ST-elevation myocardial infarction were randomly assigned to receive an intravenous bolus of either cyclosporine or saline immediately before undergoing percutaneous...

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Bibliographic Details
Published in:The New England journal of medicine Vol. 359; no. 5; pp. 473 - 481
Main Authors: Piot, Christophe, Croisille, Pierre, Staat, Patrick, Thibault, Hélène, Rioufol, Gilles, Mewton, Nathan, Elbelghiti, Rachid, Cung, Thien Tri, Bonnefoy, Eric, Angoulvant, Denis, Macia, Christophe, Raczka, Franck, Sportouch, Catherine, Gahide, Gerald, Finet, Gérard, André-Fouët, Xavier, Revel, Didier, Kirkorian, Gilbert, Monassier, Jean-Pierre, Derumeaux, Geneviève, Ovize, Michel
Format: Journal Article
Language:English
Published: Boston, MA Massachusetts Medical Society 31-07-2008
Subjects:
Angioplasty, Balloon, Coronary - adverse effects
Area Under Curve
Biological and medical sciences
Biomarkers - blood
Cardiology
Cardiology. Vascular system
Combined Modality Therapy
Coronary heart disease
Creatine Kinase - blood
Cyclosporine - adverse effects
Cyclosporine - blood
Cyclosporine - therapeutic use
Female
General aspects
Heart
Heart attacks
Humans
Ischemia
Life Sciences
Magnetic Resonance Imaging
Male
Medical imaging
Medical sciences
Middle Aged
Mitochondrial Membrane Transport Proteins - antagonists & inhibitors
Myocardial Infarction - drug therapy
Myocardial Infarction - pathology
Myocardial Infarction - therapy
Myocardial Reperfusion Injury - prevention & control
Other
Permeability
Pilot Projects
Premedication
Single-Blind Method
Troponin I - blood
Veins & arteries
Myocardial infarction
Medicine
Calcineurin inhibitor
Reperfusion
Acute
Cardiovascular disease
Ciclosporin
Immunosuppressive agent
Lesion
Coronary heart disease
Myocardial disease
Trauma
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Description
Summary:Experimental evidence suggests that cyclosporine may attenuate myocardial reperfusion injury. In a pilot trial, 58 patients with acute ST-elevation myocardial infarction were randomly assigned to receive an intravenous bolus of either cyclosporine or saline immediately before undergoing percutaneous coronary intervention. Creatine kinase release was significantly reduced in the patients who received cyclosporine. These results require confirmation in a larger trial. Experimental evidence suggests that cyclosporine may attenuate myocardial reperfusion injury. In a pilot trial, creatine kinase release was significantly reduced in the patients who received cyclosporine. Myocardial infarction is a disabling disease that is common in the United States, with more than 1.5 million new cases diagnosed each year. 1 , 2 Infarct size is a major determinant of mortality in myocardial infarction. 3 , 4 Limitation of infarct size has therefore been an important objective of strategies to improve outcomes. Currently, the most effective way to limit infarct size is to reperfuse the jeopardized myocardium as soon as possible with the use of coronary angioplasty or thrombolysis and to prevent reocclusion of the coronary artery with the use of antiplatelet therapy. Although reperfusion is undoubtedly beneficial, it has detrimental . . .
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMoa071142