Search Results - "Elbein, Alan D"

Trehalose synthase converts glycogen to trehalose by Pan, Yuan‐Tseng, Carroll, J. D., Asano, Naoki, Pastuszak, Irena, Edavana, Vineetha K., Elbein, Alan D.

“…Trehalose (α,α‐1,1‐glucosyl‐glucose) is essential for the growth of mycobacteria, and these organisms have three different pathways that can produce trehalose…”
Get full text

A novel trehalase from Mycobacterium smegmatis − purification, properties, requirements by Carroll, J. David, Pastuszak, Irena, Edavana, Vineetha K, Pan, Yuan T, Elbein, Alan D

“…Trehalose is a nonreducing disaccharide of glucose (α,α‐1,1‐glucosyl‐glucose) that is essential for growth and survival of mycobacteria. These organisms have…”
Get full text

Last Step in the Conversion of Trehalose to Glycogen by Elbein, Alan D., Pastuszak, Irena, Tackett, Alan J., Wilson, Tyler, Pan, Yuan T.

“…We show that Mycobacterium smegmatis has an enzyme catalyzing transfer of maltose from [14C]maltose 1-phosphate to glycogen. This enzyme was purified 90-fold…”
Get full text

New insights on trehalose: a multifunctional molecule by Elbein, Alan D., Pan, Y.T., Pastuszak, Irena, Carroll, David

“…Trehalose is a nonreducing disaccharide in which the two glucose units are linked in an α,α-1,1-glycosidic linkage. This sugar is present in a wide variety of…”
Get full text

Synthesis and Biological Evaluation of Aza-C-disaccharides:  (1→6), (1→4), and (1→1) Linked Sugar Mimics by Johns, Brian A, Pan, Y. T, Elbein, Alan D, Johnson, Carl R

“…The synthesis of (1→6), (1→4), and (1→1) linked aza-C-disaccharides, a novel class of glycomimetic compounds, is described. The polyhydroxylated piperidine…”
Get full text

Last Step in the Conversion of Trehalose to Glycogen: A MYCOBACTERIAL ENZYME THAT TRANSFERS MALTOSE FROM MALTOSE 1-PHOSPHATE TO GLYCOGEN by Elbein, Alan D, Pastuszak, Irena, Tackett, Alan J, Wilson, Tyler, Pan, Yuan T

“…We show that Mycobacterium smegmatis has an enzyme catalyzing transfer of maltose from [¹⁴C]maltose 1-phosphate to glycogen. This enzyme was purified 90-fold…”
Get full text

Purification, Cloning, Expression, and Properties of Mycobacterial Trehalose-phosphate Phosphatase by Klutts, Stacey, Pastuszak, Irena, Edavana, Vineetha Koroth, Thampi, Prajitha, Pan, Yuan-Tseng, Abraham, Edathera C, Carroll, J David, Elbein, Alan D

“…The trehalose-phosphate phosphatase (TPP) was purified from the cytosol of Mycobacterium smegmatis to near homogeneity using a variety of conventional steps to…”
Get full text

Mechanistic Analysis of Trehalose Synthase from Mycobacterium smegmatis by Zhang, Ran, Pan, Yuan T., He, Shouming, Lam, Michael, Brayer, Gary D., Elbein, Alan D., Withers, Stephen G.

“…Trehalose synthase (TreS) catalyzes the reversible interconversion of maltose and trehalose and has been shown recently to function primarily in the…”
Get full text

Trehalose synthase of Mycobacterium smegmatis: purification, cloning, expression, and properties of the enzyme by Pan, Yuan T, Koroth Edavana, Vineetha, Jourdian, William J, Edmondson, Rick, Carroll, J David, Pastuszak, Irena, Elbein, Alan D

“…Trehalose synthase (TreS) catalyzes the reversible interconversion of trehalose (glucosyl-alpha,alpha-1,1-glucose) and maltose (glucosyl-alpha1-4-glucose)…”
Get full text

Trehalose-based oligosaccharides isolated from the cytoplasm of Mycobacterium smegmatis. Relation to trehalose-based oligosaccharides attached to lipid by Ohta, Masaya, Pan, Y T, Laine, Roger A, Elbein, Alan D

“…A series of trehalose-based oligosaccharides were isolated from the cytoplasmic fraction of Mycobacterium smegmatis and purified by gel-filtration and paper…”
Get full text

Inhibitors of the Biosynthesis and Processing of N-Linked Oligosaccharide Chains by Elbein, A D

Get full text

Purification to homogeneity and properties of mannosidase II from mung bean seedlings by Kaushal, Gur P, Szumilo, T, Pastuszak, Irena, Elbein, Alan D

“…Mannosidase II was purified from mung bean seedlings to apparent homogeneity by using a combination of techniques including DEAE-cellulose and hydroxyapatite…”
Get full text

A route to several stereoisomers of castanospermine by Burgess, Kevin, Chaplin, David A, Henderson, Ian, Pan, Y. T, Elbein, Alan D

Get full text

Castanospermine inhibits the processing of the oligosaccharide portion of the influenza viral hemagglutinin by Pan, Y. T, Hori, Hidetaka, Saul, Rick, Sanford, Barbara A, Molyneux, Russell J, Elbein, Alan D

“…Castanospermine (1,6,7,8-tetrahydroxyoctahydroindolizine) is a plant alkaloid that inhibits alpha- and beta-glucosidase in fibroblast extracts [Saul, R.,…”
Get full text

Mechanism of action of tunicamycin on the UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase by Heifetz, Aaron, Keenan, Roy W, Elbein, Alan D

Get full text

Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis by Edavana, Vineetha Koroth, Pastuszak, Irena, Carroll, J.D, Thampi, Prajitha, Abraham, Edathera C, Elbein, Alan D

“…Two open reading frames in the Mycobacterium tuberculosis genome, Rv3372 and Rv2006, have about 25% sequence identity at the amino acid level to the…”
Get full text

Mannostatin A, a new glycoprotein-processing inhibitor by Tropea, Joseph E, Kaushal, G. P, Pastuszak, Irena, Mitchell, Mike, Aoyagi, Takaaki, Molyneux, Russell J, Elbein, Alan D

“…Mannostatin A is a metabolite produced by the microorganism Streptoverticillium verticillus and reported to be a potent competitive inhibitor of rat epididymal…”
Get full text

Mitogen-activated protein kinases in schizophrenia by Kyosseva, Svetlana V, Elbein, Alan D, Griffin, W.Sue T, Mrak, Robert E, Lyon, Melvin, Karson, Craig N

“…Background: Mitogen-activated protein kinases (MAPKs) are important mediators of signal transduction from the cell surface to the nucleus and have been…”
Get full text

Increased Expression of c-Jun Transcription Factor in Cerebellar Vermis of Patients with Schizophrenia by TODOROVA, Valentina K, ELBEIN, Alan D, KYOSSEVA, Svetlana V

“…In the cerebellar vermis of schizophrenic patients, our previous studies have revealed alterations in the mitogen-activated protein (MAP) kinase signaling…”
Get full text

Differential and Region-Specific Activation of Mitogen-Activated Protein Kinases Following Chronic Administration of Phencyclidine in Rat Brain by Kyosseva, Svetlana V, Owens, S.Michael, Elbein, Alan D, Karson, Craig N

“…We have previously demonstrated elevation of the extracellular signal-regulated kinase (ERK) pathway in the cerebellum from patients with schizophrenia, an…”
Get full text