Search Results - "Elbast, Walid"

AQW051, a novel and selective nicotinic acetylcholine receptor α7 partial agonist, reduces l -Dopa-induced dyskinesias and extends the duration of l -Dopa effects in parkinsonian monkeys by Di Paolo, Thérèse, Grégoire, Laurent, Feuerbach, Dominik, Elbast, Walid, Weiss, Markus, Gomez-Mancilla, Baltazar

“…Abstract Nicotinic acetylcholine receptor (nAChR)-mediated signaling has been implicated in levodopa ( l -Dopa)-induced dyskinesias (LID). This study…”
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Mapping the pharmaceutical design space by amorphous ionic liquid strategies by Wiest, Johannes, Saedtler, Marco, Balk, Anja, Merget, Benjamin, Widmer, Toni, Bruhn, Heike, Raccuglia, Marc, Walid, Elbast, Picard, Franck, Stopper, Helga, Dekant, Wolfgang, Lühmann, Tessa, Sotriffer, Christoph, Galli, Bruno, Holzgrabe, Ulrike, Meinel, Lorenz

“…Poor water solubility of drugs fuels complex formulations and jeopardizes patient access to medication. Simplifying these complexities we systematically…”
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Analysis of small molecule antibody-drug conjugate catabolites in rat liver and tumor tissue by liquid extraction surface analysis micro-capillary liquid chromatography/tandem mass spectrometry by Lanshoeft, Christian, Stutz, Gerhard, Elbast, Walid, Wolf, Thierry, Walles, Markus, Stoeckli, Markus, Picard, Franck, Kretz, Olivier

“…Rationale Antibody–drug conjugates (ADCs) are some of the most promising antibody‐related therapeutics. The fate of the cytotoxic moiety of ADCs in vivo after…”
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AQW051, a novel and selective nicotinic acetylcholine receptor alpha 7 partial agonist, reduces l-Dopa-induced dyskinesias and extends the duration of l-Dopa effects in parkinsonian monkeys by Paolo, Therese Di, Gregoire, Laurent, Feuerbach, Dominik, Elbast, Walid, Weiss, Markus, Gomez-Mancilla, Baltazar

“…Nicotinic acetylcholine receptor (nAChR)-mediated signaling has been implicated in levodopa (l-Dopa)-induced dyskinesias (LID). This study investigated the…”
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A Study of the Effect of Cyclosporine on Fevipiprant Pharmacokinetics and its Absolute Bioavailability Using an Intravenous Microdose Approach by Weiss, H Markus, Umehara, Ken-Ichi, Erpenbeck, Veit J, Cain, Meredith, Vemula, Janardhana, Elbast, Walid, Zollinger, Markus

“…This drug-drug interaction study determined the effect of cyclosporine, an inhibitor of organic anion transporting polypeptide (OATP) 1B3 and P-gp, on the…”
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Fevipiprant has a low risk of influencing co-medication pharmacokinetics: Impact on simvastatin and rosuvastatin in different SLCO1B1 genotypes by Poller, Birk, Woessner, Ralph, Barve, Avantika, Tillmann, Hanns-Christian, Vemula, Janardhana, Nica, Alexandra, Elbast, Walid, Schiller, Hilmar, End, Peter, Camenisch, Gian, Weiss, Markus

“…Fevipiprant, a prostaglandin D receptor 2 antagonist, is in clinical development as a treatment for asthma. The goal of this study was to assess the potential…”
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Laser diode thermal desorption atmospheric pressure chemical ionization tandem mass spectrometry applied for the ultra-fast quantitative analysis of BKM120 in human plasma by Lanshoeft, Christian, Heudi, Olivier, Leuthold, Luc Alexis, Schlotterbeck, Götz, Elbast, Walid, Picard, Franck, Kretz, Olivier

“…A sensitive and ultra-fast method utilizing the laser diode thermal desorption ion source using atmospheric pressure chemical ionization coupled to tandem mass…”
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New Insights in Tissue Distribution, Metabolism, and Excretion of [3H]-Labeled Antibody Maytansinoid Conjugates in Female Tumor-Bearing Nude Rats by Walles, Markus, Rudolph, Bettina, Wolf, Thierry, Bourgailh, Julien, Suetterlin, Martina, Moenius, Thomas, Peraus, Gisela, Heudi, Olivier, Elbast, Walid, Lanshoeft, Christian, Bilic, Sanela

“…For antibody drug conjugates (ADCs), the fate of the cytotoxic payload in vivo needs to be well understood to mitigate toxicity risks and properly design the…”
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Pharmacokinetics, Safety, and Tolerability of Fevipiprant (QAW039), a Novel CRTh2 Receptor Antagonist: Results From 2 Randomized, Phase 1, Placebo-Controlled Studies in Healthy Volunteers by Erpenbeck, Veit J., Vets, Eva, Gheyle, Lien, Osuntokun, Wande, Larbig, Michael, Neelakantham, Srikanth, Sandham, David, Dubois, Gerald, Elbast, Walid, Goldsmith, Paul, Weiss, Markus

“…We evaluated the pharmacokinetics (PK), safety, and tolerability of a novel oral CRTh2 antagonist, fevipiprant (QAW039), in healthy subjects. Peak…”
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European Bioanalysis Forum: recommendation for dealing with internal standard variability by White, Stephen, Adcock, Neil, Elbast, Walid, Hiller, Jim, Knutsson, Magnus, Lausecker, Berthold, Long, Jeff, McDougall, Stuart, Salavert, Fabrice, Sangster, Timothy, Verhaeghe, Tom, van Amsterdam, Peter

“…Adequate monitoring of internal standard (IS) response across an analytical run and identification of anomalies is now a common expectation. However, the means…”
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Analysis of urinary caffeine metabolites by HPLC-DAD: the use of metabolic ratios to assess CYP1A2 enzyme activity by Caubet, Marie-Sophie, Elbast, Walid, Dubuc, Marie-Claude, Brazier, Jean-Louis

“…An improved extraction procedure and a new RP-HPLC method were developed for selective and rapid analysis of caffeine and 14 of its metabolites in urine…”
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