Search Results - "Elbarbry, Fawzy A."
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Development and Validation of High-Throughput Bioanalytical Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Method for the Quantification of Newly Synthesized Antitumor Carbonic Anhydrase Inhibitors in Human Plasma
Published in Molecules (Basel, Switzerland) (06-12-2020)“…In the present study, a sensitive and fully validated bioanalytical high-performance liquid chromatography-tandem mass spectrometry (LC-MS/MS) method has been…”
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Liquid chromatographic determination of mycophenolic acid and its metabolites in human kidney transplant plasma: Pharmacokinetic application
Published in Journal of chromatography. B, Analytical technologies in the biomedical and life sciences (15-11-2007)“…Difference in the hydrophilic properties of mycophenolic acid metabolites makes it technically difficult to simultaneously determine their plasma levels in one…”
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Evaluation of the Assumptions of an Ontogeny Model of Rat Hepatic Cytochrome P450 Activity
Published in Drug metabolism and disposition (01-12-2007)“…We previously reported an ontogeny model of hepatic cytochrome P450 (P450) activity that predicts in vivo P450 elimination from in vitro intrinsic clearance…”
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Ontogeny of hepatic CYP1A2 and CYP2E1 expression in rat
Published in Journal of biochemical and molecular toxicology (01-03-2007)“…We report a comprehensive examination of rat hepatic CYP1A2 and CYP2E1 ontogeny. We compare the data to human data to determine the rat's capacity as a model…”
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Design and synthesis of 6-arylpyridine-tethered sulfonamides as novel selective inhibitors of carbonic anhydrase IX with promising antitumor features toward the human colorectal cancer
Published in European journal of medicinal chemistry (05-10-2023)“…Hypoxia, a characteristic feature of solid tumors, develops as a result of excessive cell proliferation and rapid tumor growth exceeding the oxygen supply, and…”
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LC–MS/MS bioanalytical method for the quantitative analysis of nifedipine, bisoprolol, and captopril in human plasma: Application to pharmacokinetic studies
Published in Biomedical chromatography (01-09-2023)“…In this study, the development and validation of an accurate and highly sensitive LC–MS/MS method were performed for the estimation of nifedipine, bisoprolol…”
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Inhibitory Effect of Two Carbonic Anhydrases Inhibitors on the Activity of Major Cytochrome P450 Enzymes
Published in European journal of drug metabolism and pharmacokinetics (01-09-2024)“…Background and Objectives Both AW-9A (coumarin derivative) and WES-1 (sulfonamide derivative) were designed and synthesized as potential selective carbonic…”
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Simple high performance liquid chromatographic assay for mycophenolic acid in renal transplant patients
Published in Journal of pharmaceutical and biomedical analysis (17-01-2007)“…A selective and highly accurate HPLC-UV method is described to determine plasma concentrations of mycophenolic acid (MPA), the active metabolite of the…”
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Therapeutic drug measurement of mycophenolic acid derivatives in transplant patients
Published in Clinical biochemistry (01-07-2007)“…Mycophenolic acid, the active metabolite of the prodrug mycophenolate mofetil, is widely used as an immunosuppressive agent in transplant patients for the…”
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Drug-Drug Interactions With Immunosuppressive Agents : Review of the In Vitro Functional Assays and Role of Cytochrome P450 Enzymes
Published in Transplantation (15-05-2008)“…Frequency of drug-drug interaction is high in most solid organ transplant recipients because of polypharmacy. These interactions involve, predominantly, the…”
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Forecasting academic success through implementation of an online prerequisite review tutorials program for first year pharmacy students
Published in Currents in pharmacy teaching and learning (01-03-2017)“…Online prerequisite review (OPR) tutorials were designed and implemented to reinforce foundational scientific material in order to protect in-class time,…”
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Determination of the analgesic components of Spasmomigraine® tablet by liquid chromatography with ultraviolet detection
Published in Journal of AOAC International (2007)“…A procedure was developed for the determination of the analgesic components of Spasmomigraine tablets, which are ergotamine (I), propyphenazone (II), caffeine…”
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Soluble Epoxide Hydrolase Inhibitory Activity of Natural Isothiocyanates
Published in American journal of pharmaceutical education (01-09-2024)Get full text
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A validated LC–MS/MS method for the quantification of amlodipine, bisoprolol, enalapril and enalaprilat—Application to pharmacokinetic study in healthy volunteers
Published in Microchemical journal (01-06-2020)“…•A highly sensitive and rapid LC–MS/MS method was developed and validated for the simultaneous determination of amlodipine (AML), bisoprolol (BIS) and…”
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