Search Results - "Elazar, Zvulun"

Mechanism and medical implications of mammalian autophagy by Dikic, Ivan, Elazar, Zvulun

“…Autophagy is a highly conserved catabolic process induced under various conditions of cellular stress, which prevents cell damage and promotes survival in the…”
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Regulation of autophagy by ROS: physiology and pathology by Scherz-Shouval, Ruth, Elazar, Zvulun

“…Reactive oxygen species (ROS) are small and highly reactive molecules that can oxidize proteins, lipids and DNA. When tightly controlled, ROS serve as…”
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Getting ready for building: signaling and autophagosome biogenesis by Abada, Adi, Elazar, Zvulun

“…Autophagy is the main cellular catabolic process responsible for degrading organelles and large protein aggregates. It is initiated by the formation of a…”
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Biogenesis and Cargo Selectivity of Autophagosomes by Weidberg, Hilla, Shvets, Elena, Elazar, Zvulun

“…Autophagy is a major catabolic pathway in eukaryotes, which is required for the lysosomal/vacuolar degradation of cytoplasmic proteins and organelles. Interest…”
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TBK1 mediates crosstalk between the innate immune response and autophagy by Weidberg, Hilla, Elazar, Zvulun

“…The autophagic pathway participates in many physiological and pathophysiological processes. Autophagy plays an important role, as part of the innate immune…”
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LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis by Weidberg, Hilla, Shvets, Elena, Shpilka, Tomer, Shimron, Frida, Shinder, Vera, Elazar, Zvulun

“…Autophagy, a critical process for bulk degradation of proteins and organelles, requires conjugation of Atg8 proteins to phosphatidylethanolamine on the…”
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The Atg8 family: multifunctional ubiquitin-like key regulators of autophagy by Slobodkin, Moran Rawet, Elazar, Zvulun

“…Autophagy is an evolutionarily-conserved catabolic process initiated by the engulfment of cytosolic components in a crescent-shaped structure, called the…”
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LC3 and GATE-16 N Termini Mediate Membrane Fusion Processes Required for Autophagosome Biogenesis by Weidberg, Hilla, Shpilka, Tomer, Shvets, Elena, Abada, Adi, Shimron, Frida, Elazar, Zvulun

“…Autophagy is a unique membrane trafficking pathway describing the formation and targeting of double membrane autophagosomes to the vacuole/lysosome. The…”
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Paternal Mitochondrial Destruction after Fertilization Is Mediated by a Common Endocytic and Autophagic Pathway in Drosophila by Politi, Yoav, Gal, Liron, Kalifa, Yossi, Ravid, Liat, Elazar, Zvulun, Arama, Eli

“…Almost all animals contain mitochondria of maternal origin only, but the exact mechanisms underlying this phenomenon are still vague. We investigated the fate…”
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p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation by Scherz-Shouval, Ruth, Weidberg, Hilla, Gonen, Chagay, Wilder, Sylvia, Elazar, Zvulun, Oren, Moshe, Levine, Arnold J.

“…The p53 tumor suppressor is mutated in a high percentage of human tumors. However, many other tumors retain wild-type (wt) p53 expression, raising the…”
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Microtubules Support Production of Starvation-induced Autophagosomes but Not Their Targeting and Fusion with Lysosomes by Fass, Ephraim, Shvets, Elena, Degani, Ilan, Hirschberg, Koret, Elazar, Zvulun

“…Autophagy is a major catabolic pathway in eukaryotic cells whereby the lack of amino acids induces the formation of autophagosomes, double-bilayer membrane…”
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Does bafilomycin A1 block the fusion of autophagosomes with lysosomes? by Klionsky, Daniel J., Elazar, Zvulun, Seglen, Per O., Rubinsztein, David C.

“…Bafilomycin A 1 is a specific inhibitor of the vacuolar type H+-ATPase (V-ATPase) in cells, and inhibits the acidification of organelles containing this…”
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A Role for NBR1 in Autophagosomal Degradation of Ubiquitinated Substrates by Kirkin, Vladimir, Lamark, Trond, Sou, Yu-Shin, Bjørkøy, Geir, Nunn, Jennifer L., Bruun, Jack-Ansgar, Shvets, Elena, McEwan, David G., Clausen, Terje H., Wild, Philipp, Bilusic, Ivana, Theurillat, Jean-Philippe, Øvervatn, Aud, Ishii, Tetsuro, Elazar, Zvulun, Komatsu, Masaaki, Dikic, Ivan, Johansen, Terje

“…Autophagy is a catabolic process where cytosolic cellular components are delivered to the lysosome for degradation. Recent studies have indicated the existence…”
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Fatty acid synthase is preferentially degraded by autophagy upon nitrogen starvation in yeast by Shpilka, Tomer, Welter, Evelyn, Borovsky, Noam, Amar, Nira, Shimron, Frida, Peleg, Yoav, Elazar, Zvulun

“…Autophagy, an evolutionarily conserved intracellular catabolic process, leads to the degradation of cytosolic proteins and organelles in the vacuole/lysosome…”
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Utilizing flow cytometry to monitor autophagy in living mammalian cells by Shvets, Elena, Fass, Ephraim, Elazar, Zvulun

“…Autophagy is a major intracellular catabolic pathway that takes part in diverse biological events including response to amino acid starvation, protein and…”
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Oxidation as a Post-Translational Modification that Regulates Autophagy by Scherz-Shouval, Ruth, Shvets, Elena, Elazar, Zvulun

“…The toxicity associated with accumulation of reactive oxygen species (ROS) has led to the evolution of various defense strategies to overcome oxidative stress,…”
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Applications of flow cytometry for measurement of autophagy by Demishtein, Alik, Porat, Ziv, Elazar, Zvulun, Shvets, Elena

“…Autophagy is a dynamic catabolic process that plays a major role in sequestering and recycling cellular components in multiple physiological and…”
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Author Correction: Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2 by Nalbach, Karsten, Schifferer, Martina, Bhattacharya, Debjani, Ho-Xuan, Hung, Tseng, Wei Chou, Williams, Luis A., Stolz, Alexandra, Lichtenthaler, Stefan F., Elazar, Zvulun, Behrends, Christian

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Spatial proteomics reveals secretory pathway disturbances caused by neuropathy-associated TECPR2 by Nalbach, Karsten, Schifferer, Martina, Bhattacharya, Debjani, Ho-Xuan, Hung, Tseng, Wei Chou, Williams, Luis A., Stolz, Alexandra, Lichtenthaler, Stefan F., Elazar, Zvulun, Behrends, Christian

“…Hereditary sensory and autonomic neuropathy 9 (HSAN9) is a rare fatal neurological disease caused by mis- and nonsense mutations in the gene encoding for…”
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Mutation in TECPR2 Reveals a Role for Autophagy in Hereditary Spastic Paraparesis by Oz-Levi, Danit, Ben-Zeev, Bruria, Ruzzo, Elizabeth K., Hitomi, Yuki, Gelman, Amir, Pelak, Kimberly, Anikster, Yair, Reznik-Wolf, Haike, Bar-Joseph, Ifat, Olender, Tsviya, Alkelai, Anna, Weiss, Meira, Ben-Asher, Edna, Ge, Dongliang, Shianna, Kevin V., Elazar, Zvulun, Goldstein, David B., Pras, Elon, Lancet, Doron

“…We studied five individuals from three Jewish Bukharian families affected by an apparently autosomal-recessive form of hereditary spastic paraparesis…”
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