Search Results - "Elayouby, Karim S"
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Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer's disease
Published in eLife (21-06-2024)“…Maternal choline supplementation (MCS) improves cognition in Alzheimer's disease (AD) models. However, the effects of MCS on neuronal hyperexcitability in AD…”
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Neurobiological Mechanisms of Nicotine Reward and Aversion
Published in Pharmacological reviews (01-01-2022)“…Neuronal nicotinic acetylcholine receptors (nAChRs) regulate the rewarding actions of nicotine contained in tobacco that establish and maintain the smoking…”
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Habenular TCF7L2 links nicotine addiction to diabetes
Published in Nature (London) (01-10-2019)“…Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the…”
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α3 Nicotinic Acetylcholine Receptors in the Habenula-Interpeduncular Nucleus Circuit Regulate Nicotine Intake
Published in The Journal of neuroscience (24-02-2021)“…Allelic variation in , the gene encoding the α3 nicotinic acetylcholine receptor (nAChR) subunit, increases vulnerability to tobacco dependence and…”
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Hedgehog-interacting protein acts in the habenula to regulate nicotine intake
Published in Proceedings of the National Academy of Sciences - PNAS (15-11-2022)“…Hedgehog-interacting protein (HHIP) sequesters Hedgehog ligands to repress Smoothened (SMO)-mediated recruitment of the GLI family of transcription factors…”
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Choline supplementation in early life improves and low levels of choline can impair outcomes in a mouse model of Alzheimer’s disease
Published in eLife (21-06-2024)“…Maternal choline supplementation (MCS) improves cognition in Alzheimer’s disease (AD) models. However, the effects of MCS on neuronal hyperexcitability in AD…”
Get full text
Journal Article