Search Results - "Elamin, Ashraf"

Comparative systems toxicology analysis of cigarette smoke and aerosol from a candidate modified risk tobacco product in organotypic human gingival epithelial cultures: A 3-day repeated exposure study by Zanetti, Filippo, Titz, Bjoern, Sewer, Alain, Lo Sasso, Giuseppe, Scotti, Elena, Schlage, Walter K., Mathis, Carole, Leroy, Patrice, Majeed, Shoaib, Torres, Laura Ortega, Keppler, Brian R., Elamin, Ashraf, Trivedi, Keyur, Guedj, Emmanuel, Martin, Florian, Frentzel, Stefan, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia

“…Smoking is one of the major lifestyle-related risk factors for periodontal diseases. Modified risk tobacco products (MRTP) offer a promising alternative in the…”
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Proteomics and Lipidomics in Inflammatory Bowel Disease Research: From Mechanistic Insights to Biomarker Identification by Titz, Bjoern, Gadaleta, Raffaella M, Lo Sasso, Giuseppe, Elamin, Ashraf, Ekroos, Kim, Ivanov, Nikolai V, Peitsch, Manuel C, Hoeng, Julia

“…Inflammatory bowel disease (IBD) represents a group of progressive disorders characterized by recurrent chronic inflammation of the gut. Ulcerative colitis and…”
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A 7-month cigarette smoke inhalation study in C57BL/6 mice demonstrates reduced lung inflammation and emphysema following smoking cessation or aerosol exposure from a prototypic modified risk tobacco product by Phillips, Blaine, Veljkovic, Emilija, Peck, Michael J., Buettner, Ansgar, Elamin, Ashraf, Guedj, Emmanuel, Vuillaume, Gregory, Ivanov, Nikolai V., Martin, Florian, Boué, Stéphanie, Schlage, Walter K., Schneider, Thomas, Titz, Bjoern, Talikka, Marja, Vanscheeuwijck, Patrick, Hoeng, Julia, Peitsch, Manuel C.

“…•Lung inflammation and emphysema increased from 2 to 7 month CS exposure.•Cessation reverted most inflammatory processes and halted emphysematous…”
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Multi-omics systems toxicology study of mouse lung assessing the effects of aerosols from two heat-not-burn tobacco products and cigarette smoke by Titz, Bjoern, Szostak, Justyna, Sewer, Alain, Phillips, Blaine, Nury, Catherine, Schneider, Thomas, Dijon, Sophie, Lavrynenko, Oksana, Elamin, Ashraf, Guedj, Emmanuel, Tsin Wong, Ee, Lebrun, Stefan, Vuillaume, Grégory, Kondylis, Athanasios, Gubian, Sylvain, Cano, Stephane, Leroy, Patrice, Keppler, Brian, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Martin, Florian, Peitsch, Manuel C., Hoeng, Julia

“…[Display omitted] •Multi-omics systems toxicology study, comprising five omics data modalities.•Multi-Omics Factor Analysis and multi-modality functional…”
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Proteomics for systems toxicology by Titz, Bjoern, Elamin, Ashraf, Martin, Florian, Schneider, Thomas, Dijon, Sophie, Ivanov, Nikolai V., Hoeng, Julia, Peitsch, Manuel C.

“…Current toxicology studies frequently lack measurements at molecular resolution to enable a more mechanism-based and predictive toxicological assessment…”
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Central Nervous System Vasculitis as a Rare Presentation of Mycoplasma pneumoniae: A Case Report by Ahmed, Ashraf Omer Elamin, Babikir, Mona Mohammad Ibraheem, Khojali, Amir Elssoni Mahjoup, Arachchige, Suresh Nalaka Menik, Abdirahman, Abdirahman Mohamud, Mohamed, Mouhand Faisal Hamad

“…Mycobacteria pneumoniae (MP) commonly causes upper and lower respiratory tract infections. The clinical manifestation is classified as pulmonary and…”
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S1884 Secondary Aortoesophageal Fistula: Time to Improve Its Diagnosis by Elamin, Ashraf, Nathan, Swami

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MitraClip to the rescue in cardiogenic shock: Case series from a single center by Ahmed, Ashraf, Mohammed, Nazar, Alzaeem, Hakam, Jalil, Syed, Maaly, Cheikh, Al-Hijji, Mohammed

“…Cardiogenic shock (CS) in the setting of acute coronary syndrome carries detrimental consequences and high levels of mortality and morbidity if not managed…”
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Acute abdomen -like-presentation associated with SARS-CoV-2 infection by Ahmed, Ashraf Omer Elamin, Mohamed, Sara F., Saleh, Ahmed O., Al-Shokri, Shaikha D., Ahmed, Khalid, Mohamed, Mouhand F.H.

“…As the cases of COVID-19 are flooding around the world, atypical presentations are being recognized, making the diagnosis challenging. Gastrointestinal…”
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THE IMPACT OF TYROSINE KINASE INHIBITORS ON FATHERHOOD IN PATIENTS WITH CHRONIC MYELOID LEUKEMIA, A SINGLE INSTITUTION EXPERIENCE by Mohammad Abu-Tineh, Awni Alshurafa, Elrazi Awadelkarim Hamid Ali, Yousef Hailan, Waail Rozi, Abdulqader nashwan, mohamed yassin, Ashraf Omer Elamin Ahmed, Khalid Mohamed Ibrahim Alhaj ALbsheer

“…Objective: Following the launch of the TKI's (tyrosine kinase inhibitors) for the treatment of CML, establishing its significant control over the disease,…”
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Toxicity of the main electronic cigarette components, propylene glycol, glycerin, and nicotine, in Sprague-Dawley rats in a 90-day OECD inhalation study complemented by molecular endpoints by Phillips, Blaine, Titz, Bjoern, Kogel, Ulrike, Sharma, Danilal, Leroy, Patrice, Xiang, Yang, Vuillaume, Grégory, Lebrun, Stefan, Sciuscio, Davide, Ho, Jenny, Nury, Catherine, Guedj, Emmanuel, Elamin, Ashraf, Esposito, Marco, Krishnan, Subash, Schlage, Walter K., Veljkovic, Emilija, Ivanov, Nikolai V., Martin, Florian, Peitsch, Manuel C., Hoeng, Julia, Vanscheeuwijck, Patrick

“…While the toxicity of the main constituents of electronic cigarette (ECIG) liquids, nicotine, propylene glycol (PG), and vegetable glycerin (VG), has been…”
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Complete Superior and Inferior Vena Cava Obstruction Associated with Systemic-to-Pulmonary Venous Shunts in a Young Female with Heterozygous Prothrombin G20210A Gene Mutation by Ahmed, Ashraf Omer Elamin, Elfert, Khaled A., Mahfouz, Ahmed E., Othman, Fahmi S., Elgassim, Lenah A., Yassin, Mohamed A.

“…Complete superior vena cava (SVC) and inferior vena cava (IVC) obstruction is not uncommon and most commonly associated with malignancy. The risk increases in…”
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TOBACCO HEATING SYSTEM 2.2 IN MILD TO MODERATE COPD SUBJECTS: AN EXPLORATORY ANALYSIS by Ansari, S. Michael, Sergio, Francesco, Medlin, Loyse Felber, Lama, Nicola, Elamin, Ashraf, Haziza, Christelle

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An 8-Month Systems Toxicology Inhalation/Cessation Study in Apoe-/- Mice to Investigate Cardiovascular and Respiratory Exposure Effects of a Candidate Modified Risk Tobacco Product, THS 2.2, Compared With Conventional Cigarettes by Phillips, Blaine, Veljkovic, Emilija, Boué, Stéphanie, Schlage, Walter K, Vuillaume, Gregory, Martin, Florian, Titz, Bjoern, Leroy, Patrice, Buettner, Ansgar, Elamin, Ashraf, Oviedo, Alberto, Cabanski, Maciej, De León, Héctor, Guedj, Emmanuel, Schneider, Thomas, Talikka, Marja, Ivanov, Nikolai V, Vanscheeuwijck, Patrick, Peitsch, Manuel C, Hoeng, Julia

“…Smoking cigarettes is a major risk factor in the development and progression of cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD)…”
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A six-month systems toxicology inhalation/cessation study in ApoE−/− mice to investigate cardiovascular and respiratory exposure effects of modified risk tobacco products, CHTP 1.2 and THS 2.2, compared with conventional cigarettes by Phillips, Blaine, Szostak, Justyna, Titz, Bjoern, Schlage, Walter K., Guedj, Emmanuel, Leroy, Patrice, Vuillaume, Gregory, Martin, Florian, Buettner, Ansgar, Elamin, Ashraf, Sewer, Alain, Sierro, Nicolas, Choukrallah, Mohamed Amin, Schneider, Thomas, Ivanov, Nikolai V., Teng, Charles, Tung, Ching Keong, Lim, Wei Ting, Yeo, Ying Shan, Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia

“…Smoking is one of the major modifiable risk factors in the development and progression of chronic obstructive pulmonary disease (COPD) and cardiovascular…”
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Systems Toxicology Assessment of the Biological Impact of a Candidate Modified Risk Tobacco Product on Human Organotypic Oral Epithelial Cultures by Zanetti, Filippo, Sewer, Alain, Mathis, Carole, Iskandar, Anita R, Kostadinova, Radina, Schlage, Walter K, Leroy, Patrice, Majeed, Shoaib, Guedj, Emmanuel, Trivedi, Keyur, Martin, Florian, Elamin, Ashraf, Merg, Céline, Ivanov, Nikolai V, Frentzel, Stefan, Peitsch, Manuel C, Hoeng, Julia

“…Cigarette smoke (CS) has been reported to increase predisposition to oral cancer and is also recognized as a risk factor for many conditions including…”
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A 90-day OECD TG 413 rat inhalation study with systems toxicology endpoints demonstrates reduced exposure effects of the aerosol from the carbon heated tobacco product version 1.2 (CHTP1.2) compared with cigarette smoke. I. Inhalation exposure, clinical pathology and histopathology by Phillips, Blaine W., Schlage, Walter K., Titz, Bjoern, Kogel, Ulrike, Sciuscio, Davide, Martin, Florian, Leroy, Patrice, Vuillaume, Gregory, Krishnan, Subash, Lee, Tom, Veljkovic, Emilija, Elamin, Ashraf, Merg, Celine, Ivanov, Nikolai V., Peitsch, Manuel C., Hoeng, Julia, Vanscheeuwijck, Patrick

“…Within the framework of a systems toxicology approach, the inhalation toxicity of aerosol from a novel tobacco-heating potentially modified risk tobacco…”
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Effects of Cigarette Smoke, Cessation, and Switching to Two Heat-Not-Burn Tobacco Products on Lung Lipid Metabolism in C57BL/6 and Apoe-/- Mice-An Integrative Systems Toxicology Analysis by Titz, Bjoern, Boué, Stéphanie, Phillips, Blaine, Talikka, Marja, Vihervaara, Terhi, Schneider, Thomas, Nury, Catherine, Elamin, Ashraf, Guedj, Emmanuel, Peck, Michael J, Schlage, Walter K, Cabanski, Maciej, Leroy, Patrice, Vuillaume, Gregory, Martin, Florian, Ivanov, Nikolai V, Veljkovic, Emilija, Ekroos, Kim, Laaksonen, Reijo, Vanscheeuwijck, Patrick, Peitsch, Manuel C, Hoeng, Julia

“…The impact of cigarette smoke (CS), a major cause of lung diseases, on the composition and metabolism of lung lipids is incompletely understood. Here, we…”
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Evaluation of the Tobacco Heating System 2.2. Part 7: Systems toxicological assessment of a mentholated version revealed reduced cellular and molecular exposure effects compared with mentholated and non-mentholated cigarette smoke by Kogel, Ulrike, Titz, Bjoern, Schlage, Walter K., Nury, Catherine, Martin, Florian, Oviedo, Alberto, Lebrun, Stefan, Elamin, Ashraf, Guedj, Emmanuel, Trivedi, Keyur, Ivanov, Nikolai V., Vanscheeuwijck, Patrick, Peitsch, Manuel C., Hoeng, Julia

“…Modified risk tobacco products (MRTPs) are being developed with the aim of reducing smoking-related health risks. The Tobacco Heating System 2.2 (THS2.2) is a…”
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Alterations in the sputum proteome and transcriptome in smokers and early-stage COPD subjects by Titz, Bjoern, Sewer, Alain, Schneider, Thomas, Elamin, Ashraf, Martin, Florian, Dijon, Sophie, Luettich, Karsta, Guedj, Emmanuel, Vuillaume, Gregory, Ivanov, Nikolai V., Peck, Michael J., Chaudhary, Nveed I., Hoeng, Julia, Peitsch, Manuel C.

“…Chronic obstructive pulmonary disease (COPD) is one of the most prevalent lung diseases. Cigarette smoking is the main risk factor for COPD. In this…”
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