β-glucan mitigates ovalbumin-induced airway inflammation by preventing oxidative stress and CD8+ T cell infiltration

[Display omitted] •Beta-glucan displayed anti-inflammatory and antioxidant potential in asthmatic mice.•Beta-glucan attenuated ovalbumin-induced oxidative stress.•Beta-glucan reduced histopathological alterations, IgE secretion, and airway inflammation.•Beta-glucan suppressed the infiltration of CD8...

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Published in:	International immunopharmacology Vol. 132; p. 111985
Main Authors:	Abdelmawgood, Islam Ahmed, Kotb, Mohamed A., Ashry, Hamid, Ebeed, Bassam W., Mahana, Noha A., Mohamed, Ayman Saber, Eid, Jehane I., Ramadan, Marwa A., Rabie, Nahla S., Mohamed, Mariam Y., Saed, Nermeen Th, Yasser, Nada, Essam, Dina, Zaki, Youssef Y., Saeed, Samar, Mahmoud, Asmaa, Eladawy, Marwan M., Badr, Abeer Mahmoud
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 10-05-2024
Subjects:	Allergic asthma Animals Anti-Asthmatic Agents - pharmacology Anti-Asthmatic Agents - therapeutic use Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Asthma - chemically induced Asthma - drug therapy Asthma - immunology Beta-glucan beta-Glucans - chemistry beta-Glucans - pharmacology beta-Glucans - therapeutic use CD8+ T cells CD8-Positive T-Lymphocytes - drug effects CD8-Positive T-Lymphocytes - immunology Disease Models, Animal Female Immunoglobulin E - blood Inflammation Lung - drug effects Lung - immunology Lung - pathology Mice Mice, Inbred BALB C Ovalbumin Ovalbumin - immunology Oxidative stress Oxidative Stress - drug effects Ovalbumin Allergic asthma Oxidative stress CD8+ T cells Inflammation Beta-glucan CD8(+) T cells
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Summary:	[Display omitted] •Beta-glucan displayed anti-inflammatory and antioxidant potential in asthmatic mice.•Beta-glucan attenuated ovalbumin-induced oxidative stress.•Beta-glucan reduced histopathological alterations, IgE secretion, and airway inflammation.•Beta-glucan suppressed the infiltration of CD8+ T cells in asthmatic mice. Bronchial asthma is a severe respiratory condition characterized by airway inflammation, remodeling, and oxidative stress. β-Glucan (BG) is a polysaccharide found in fungal cell walls with powerful immunomodulatory properties. This study examined and clarified the mechanisms behind BG's ameliorativeactivitiesin an allergic asthma animal model. BG was extracted from Chaga mushroom and characterized using FT-IR, UV–visible, zeta potential, and 1H NMR analysis. The mice were divided into five groups, including control, untreated asthmatic, dexamethasone (Dexa)-treated (1 mg/kg), and BG (30 and 100 mg/kg)-treated groups. BG treatment reduced nasal scratching behavior, airway-infiltrating inflammatory cells, and serum levels of IgE significantly. Additionally, BG attenuated oxidative stress biomarkers by lowering malonaldehyde (MDA) concentrations and increasing the levels of reduced glutathione (GSH), glutathione peroxidase (GPx), and catalase (CAT). Immunohistochemical and flow cytometric analyses have confirmed the suppressive effect of BG on the percentage of airway-infiltrating cytotoxic CD8+ T cells. The findings revealed the role of CD8+ T cells in the pathogenesis of asthma and the role of BG as a potential therapeutic agent for asthma management through the suppression of airway inflammation and oxidative stress.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1567-5769 1878-1705
DOI:	10.1016/j.intimp.2024.111985