Search Results - "Elaasser, Mahmoud M"

Synthesis and Anticancer Activities of Thiazoles, 1,3-Thiazines, and Thiazolidine Using Chitosan-Grafted-Poly(vinylpyridine) as Basic Catalyst by M. Riyadh, Sayed, M. Gomha, Sobhi, A. Mahmmoud, Elmahdi, M. Elaasser, Mahmoud

Get full text

Synthesis of Novel Chalcone-Based Phenothiazine Derivatives as Antioxidant and Anticancer Agents by Al Zahrani, Nourah A, El-Shishtawy, Reda M, Elaasser, Mahmoud M, Asiri, Abdullah M

“…Based on reported results for the potential medicinal impact of phenothiazine core, as well as the chalcone skeleton that is widely present in many natural…”
Get full text

Discovery of 3,6-disubstituted pyridazines as a novel class of anticancer agents targeting cyclin-dependent kinase 2: synthesis, biological evaluation and in silico insights by Sabt, Ahmed, Eldehna, Wagdy M., Al-Warhi, Tarfah, Alotaibi, Ohoud J., Elaasser, Mahmoud M., Suliman, Howayda, Abdel-Aziz, Hatem A.

“…Human health in the current medical era is facing numerous challenges, especially cancer. So, the therapeutic arsenal for cancer should be unremittingly…”
Get full text

Novel Thiazolidinone/Thiazolo[3,2- a ]Benzimidazolone-Isatin Conjugates as Apoptotic Anti-proliferative Agents Towards Breast Cancer: One-Pot Synthesis and In Vitro Biological Evaluation by El-Naggar, Mohamed, Eldehna, Wagdy M, Almahli, Hadia, Elgez, Amr, Fares, Mohamed, Elaasser, Mahmoud M, Abdel-Aziz, Hatem A

“…In connection with our research program on the development of new isatin-based anticancer candidates, herein we report the synthesis of two novel series of…”
Get full text

Natural inspired ligustrazine-based SLC-0111 analogues as novel carbonic anhydrase inhibitors by Elimam, Diaaeldin M., Eldehna, Wagdy M., Salem, Rofaida, Bonardi, Alessandro, Nocentini, Alessio, Al-Rashood, Sara T., Elaasser, Mahmoud M., Gratteri, Paola, Supuran, Claudiu T., Allam, Heba Abdelrasheed

“…Ligustrazine is the principle bioactive alkaloid in the widely-used Chinese herb Chuan Xiong rhizome. Herein, a series of novel derivatives has been designed…”
Get full text

Fabrication and characterization of unique sustain modified chitosan nanoparticles for biomedical applications by Ahmed, Marwa ElS, Mohamed, Mansoura I., Ahmed, Hanaa Y., Elaasser, Mahmoud M., Kandile, Nadia G.

“…Chitosan (CS) is a biopolymer that offers a wide range in biomedical applications due to its biocompatibility, biodegradability, low toxicity and antimicrobial…”
Get full text

Improvement of antibacterial activity of some sulfa drugs through linkage to certain phthalazin-1(2H)-one scaffolds by Ibrahim, Hany S., Eldehna, Wagdy M., Abdel-Aziz, Hatem A., Elaasser, Mahmoud M., Abdel-Aziz, Marwa M.

“…RAB1 5 is a lead antibacterial agent in which trimethoprim is linked to phthalazine moiety. Similarly, our strategy in this research depends on the…”
Get full text

Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies by Al-Warhi, Tarfah, Abo-Ashour, Mahmoud F., Almahli, Hadia, Alotaibi, Ohoud J., Al-Sanea, Mohammad M., Al-Ansary, Ghada H., Ahmed, Hanaa Y., Elaasser, Mahmoud M., Eldehna, Wagdy M., Abdel-Aziz, Hatem A.

“…As a continuation for our previous work, a novel set of N-alkylindole-isatin conjugates (7, 8a-c, 9 and 10a-e) is here designed and synthesised with the prime…”
Get full text

Discovery of novel thiazolyl-pyrazolines as dual EGFR and VEGFR-2 inhibitors endowed with in vitro antitumor activity towards non-small lung cancer by Abdelsalam, Esraa A., Abd El-Hafeez, Amer Ali, Eldehna, Wagdy M., El Hassab, Mahmoud A., Marzouk, Hala Mohamed M., Elaasser, Mahmoud M., Abou Taleb, Nageh A., Amin, Kamilia M., Abdel-Aziz, Hatem A., Ghosh, Pradipta, Hammad, Sherif F.

“…New series of thiazolyl-pyrazoline derivatives (7a-7d, 10a-10d and 13a-13f) have been synthesised and assessed for their potential EGFR and VEGFR-2 inhibitory…”
Get full text

Novel [(3-indolylmethylene)hydrazono]indolin-2-ones as apoptotic anti-proliferative agents: design, synthesis and in vitro biological evaluation by Eldehna, Wagdy M., Abo-Ashour, Mahmoud F., Ibrahim, Hany S., Al-Ansary, Ghada H., Ghabbour, Hazem A., Elaasser, Mahmoud M., Ahmed, Hanaa Y. A., Safwat, Nesreen A.

“…On account of their significance as apoptosis inducing agents, merging indole and 3-hydrazinoindolin-2-one scaffolds is a logic tactic for designing…”
Get full text

Antimicrobial and anticancer activity of some novel fluorinated thiourea derivatives carrying sulfonamide moieties: synthesis, biological evaluation and molecular docking by Ghorab, Mostafa M., Alsaid, Mansour S., El-Gaby, Mohamed S. A., Elaasser, Mahmoud M., Nissan, Yassin M.

“…Background Various thiourea derivatives have been used as starting materials for compounds with better biological activities. Molecular modeling tools are used…”
Get full text

Synthesis and Biological Evaluation of Thiazolyl-Ethylidene Hydrazino-Thiazole Derivatives: A Novel Heterocyclic System by Al-Mutabagani, Laila A., Abdelrazek, Fathy M., Gomha, Sobhi M., Hebishy, Ali S., Abdelfattah, Mohamed S., Hassan, Safaa M., Sayed, Abdelwahed R., Elaasser, Mahmoud M.

“…The reaction of 2-(1-(2-(2-(4-methoxybenzylidene)hydrazinyl)-4-methylthiazol-5-yl)ethylidene)hydrazinecarbothioamide with a range of hydrazonoyl chlorides and…”
Get full text

Application of Mannich and Michael Reactions in Synthesis of Pyridopyrimido[2,1-b][1,3,5]thiadiazinones and Pyridopyrimido[2,1-b][1,3]thiazinones as Anticancer Agents by M. Gomha, Sobhi, A. Abdallah, Magda, A. Mourad, Mahmoud, M. Elaasser, Mahmoud

Get full text

Synthesis, docking study and biological evaluation of some new thiourea derivatives bearing benzenesulfonamide moiety by Ghorab, Mostafa M., El-Gaby, Mohamed S. A., Soliman, Aiten M., Alsaid, Mansour S., Abdel-Aziz, Marwa M., Elaasser, Mahmoud M.

“…Background A series of novel N -(2, 6-dimethoxypyrimidin-4-yl)-4-(3-(aryl)thioureido) benzenesulfonamides 3a – t was synthesized by the addition of N…”
Get full text

Antimicrobial and anticancer evaluation of a novel synthetic tetracyclic system obtained by Dimroth rearrangement by Gomha Sobhi M., Abbas Ikhlass M., Elneairy Mohamed A.A., Elaasser Mahmoud M., Mabrouk Bazada K.A.

“…A series of pyrido[3',2':4,5]thieno[2,3-e][1,2,4]triazolo[4,3-c]pyrimidines were prepared via oxidative cyclization of 4-(2-arylidenehydrazinyl)pyrido…”
Get full text

Design, synthesis and 2D QSAR study of novel pyridine and quinolone hydrazone derivatives as potential antimicrobial and antitubercular agents by Abdelrahman, Mohamed A., Salama, Ismail, Gomaa, Mohamed S., Elaasser, Mahmoud M., Abdel-Aziz, Marwa M., Soliman, Dalia H.

“…The increased development of highly resistant bacterial strains and tuberculosis, constitute a serious public health threat, highlighting the urgent need of…”
Get full text

Novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino) benzenesulfonamides: Synthesis, carbonic anhydrase inhibitory activity, anticancer activity and molecular modelling studies by Eldehna, Wagdy M., Abo-Ashour, Mahmoud F., Nocentini, Alessio, Gratteri, Paola, Eissa, Ibrahim H., Fares, Mohamed, Ismael, Omnia E., Ghabbour, Hazem A., Elaasser, Mahmoud M., Abdel-Aziz, Hatem A., Supuran, Claudiu T.

“…Herein we report the synthesis of two series of novel 4/3-((4-oxo-5-(2-oxoindolin-3-ylidene)thiazolidin-2-ylidene)amino)benzenesulfonamides (4a-m and 7a-g)…”
Get full text

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights by Abo-Ashour, Mahmoud F., Eldehna, Wagdy M., Nocentini, Alessio, Bonardi, Alessandro, Bua, Silvia, Ibrahim, Hany S., Elaasser, Mahmoud M., Kryštof, Vladimír, Jorda, Radek, Gratteri, Paola, Abou-Seri, Sahar M., Supuran, Claudiu T.

“…Herein we describe the design and synthesis of two series of sulfonamides featuring N-unsubstituted (4a-c) or N-substituted (7a-o) isatin moieties (as tails)…”
Get full text

Isatin-pyrazole benzenesulfonamide hybrids potently inhibit tumor-associated carbonic anhydrase isoforms IX and XII by Ibrahim, Hany S., Abou-Seri, Sahar M., Tanc, Muhammet, Elaasser, Mahmoud M., Abdel-Aziz, Hatem A., Supuran, Claudiu T.

“…New series of benzenesulfonamide derivatives incorporating pyrazole and isatin moieties were prepared using celecoxib as lead molecule. Biological evaluation…”
Get full text

Novel indole-thiazolidinone conjugates: Design, synthesis and whole-cell phenotypic evaluation as a novel class of antimicrobial agents by Abo-Ashour, Mahmoud F., Eldehna, Wagdy M., George, Riham F., Abdel-Aziz, Marwa M., Elaasser, Mahmoud M., Abdel Gawad, Nagwa M., Gupta, Antima, Bhakta, Sanjib, Abou-Seri, Sahar M.

“…In connection with our research program on the development of novel anti-tubercular candidates, herein we report the design and synthesis of two different sets…”
Get full text