Search Results - "ElTahir, Kamal E.H."

Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study by El-Sayed, Magda A.-A., Abdel-Aziz, Naglaa I., Abdel-Aziz, Alaa A.-M., El-Azab, Adel S., Asiri, Yousif A., ElTahir, Kamal E.H.

“…A series of hydrazone and pyrazole derivatives were prepared and evaluated for their anti-inflammatory activities and selectivity as COX-2 inhibitor. New…”
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Design and synthesis of novel 7-aminoquinazoline derivatives: Antitumor and anticonvulsant activities by El-Azab, Adel S., ElTahir, Kamal E.H.

“…Compound 7 showed broad-spectrum antitumor activity, while compound 15 showed advanced anticonvulsant activity as well as lower toxicity than reference drugs…”
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Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2 by Al-Suwaidan, Ibrahim A., Alanazi, Amer M., El-Azab, Adel S., Al-Obaid, Abdulrahman M., ElTahir, Kamal E.H., Maarouf, Azza R., Abu El-Enin, Mohamed A., Abdel-Aziz, Alaa A.-M.

“…A group of cyclic imides (1–10) was designed for evaluation as a selective COX-2 inhibitors and investigated in vivo for their anti-inflammatory activity…”
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Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2 by El-Sayed, Magda A.-A., Abdel-Aziz, Naglaa I., Abdel-Aziz, Alaa A.-M., El-Azab, Adel S., ElTahir, Kamal E.H.

“…New pyrazole and pyrazoline derivatives have been synthesized and their ability to inhibit ovine COX-1/COX-2 isozymes was evaluated using in vitro…”
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Synthesis and anticonvulsant evaluation of some new 2,3,8-trisubstituted-4(3H)-quinazoline derivatives by El-Azab, Adel S., ElTahir, Kamal E.H.

“…A new series of 2,3,8-trisubstituted-4(3H)-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against electrically (MES) and…”
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Synthesis and in-silico studies of some diaryltriazole derivatives as potential cyclooxygenase inhibitors by Radwan, Awwad A., elTahir, Kamal E. H.

“…The synthesis of several 4-phenyl-5-pyridin-4-yl-2,3-dihydro-3H-1,2,4-triazole-3-thiones possessing N-2 Mannich bases or S-alkyl substituents, is reported…”
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Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study by Abdel-Aziz, Alaa A.-M., ElTahir, Kamal E.H., Asiri, Yousif A.

“…A group of cyclic imides ( 1– 13) was designed for evaluation as selective COX-2 inhibitors and investigated in vivo for their anti-inflammatory activities…”
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Synthesis and anticonvulsant evaluation of some novel 4(3H)-quinazolinones by El-Azab, Adel S., ElTahir, Kamal E. H., Attia, Sabry M.

“…A series of novel quinazoline derivatives, methaqualone analogs, were synthesized, evaluated for their anticonvulsant activity against electrically and…”
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Synthesis, biological evaluation and molecular docking studies of thiazole-based pyrrolidinones and isoindolinediones as anticonvulsant agents by Ghabbour, Hazem A., Kadi, Adnan A., ElTahir, Kamal E. H., Angawi, Rihab F., El-Subbagh, Hussein I.

“…A series of new 1-(thiazol-2-yl)pyrrolidin-2-one 5a – m and 2-(thiazol-2-yl)isoindoline-1,3-dione 6a – n derivatives were synthesized and evaluated for…”
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Design, synthesis and anticonvulsant evaluation of novel 8-substituted-4(3H)-quinazolines by El-Azab, Adel S., ElTahir, Kamal E. H.

“…A new series of 8-substituted-4(3 H )-quinazoline derivatives were synthesized, evaluated for their anticonvulsant activity against chemically (PTZ, picrotoxin…”
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Influence of diethylcarbamazine and mefloquine on PGI2 synthesis by the rat thoracic aorta and myometrial tissues by el Tahir, K E, al-Kharji, A M, Ageel, A M

“…1. The influence of the antifilarial drug diethylcarbamazine citrate (D) and DL-erythro mefloquine hydrochloride (Mf) on PGI2 synthesis by the male rat…”
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Effects of N-methyl- and N-isobutyl-1,2-diphenyl ethanol amines on the spontaneous and evoked contractions in the rat isolated uterus by el Tahir, K E, el Nasser, M A, Ageel, A M, el-Obeid, H A, al-Rashood, K A

“…1. The effects of N-methyl- and N-isobutyl-1,2-diphenyl ethanol amine (compounds M & E), respectively and diltiazem (D) were examined on the spontaneous and…”
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