Effectiveness of combined therapy radiofrequency ablation/transarterial chemoembolization versus transarterial chemoembolization/radiofrequency ablation on management of hepatocellular carcinoma
BACKGROUNDOne of the most widespread cancer-associated death worldwide is Hepatocellular carcinoma. Concerning hepatic malignant tumor staging system known as Barcelona clinic of liver cancer, a superior curative response could be carried out by combined techniques [radiofrequency ablation (RFA) and...
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| Published in: | European journal of gastroenterology & hepatology Vol. 33; no. 12; pp. 1573 - 1577 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Wolters Kluwer Health, Inc. All rights reserved
01-12-2021
Copyright Wolters Kluwer Health, Inc. All rights reserved |
| Online Access: | Get full text |
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| Summary: | BACKGROUNDOne of the most widespread cancer-associated death worldwide is Hepatocellular carcinoma. Concerning hepatic malignant tumor staging system known as Barcelona clinic of liver cancer, a superior curative response could be carried out by combined techniques [radiofrequency ablation (RFA) and transarterial chemoembolization (TACE)] for stage B comparing with TACE alone as palliative monotherapy.
OBJECTIVESTo discuss the merging effect of RFA followed by TACE and vice versa on objective response, overall survival, local recurrence and tumor-free survival.
PATIENTS AND METHODSSixty-eight cases included with hepatic tumor on top of chronic liver disease post-viral infection and divided into two groups according to different combined treatment modality; first cohort included 34 patients treated with TACE followed by RFA, while the second one included 34 patients treated with RFA followed by TACE for two lesions or single medium-sized lesion stage.
RESULTSComplete response and objective response rates were 91% and 82% after TACE/RFA and 100% and 91% after RFA/TACE, respectively. Regarding Milan criteria, there was significant downstaging after RFA/TACE (P < 0.05). First and second overall survival rates were 85% and 65% after TACE/RFA versus 100% and 74%, respectively, after RFA/TACE (P > 0.05). Kaplan–Meier curve as regards disease-free survival rate, median time were 17.1 months [95% confidence interval (CI) 12.2–22.0] in TACE/RFA and 23.2 (95% CI 18.1–28.2) months in RFA/TACE (P > 0.05).
CONCLUSIONRFA/TACE showed effective complete response, downstaging, disease-free survival and overall survival for the treatment of hepatic malignant tumors. |
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| ISSN: | 0954-691X 1473-5687 |
| DOI: | 10.1097/MEG.0000000000001878 |