Search Results - "El Qaidi, Samir"

Arginine glycosylation enhances methylglyoxal detoxification by El Qaidi, Samir, Scott, Nichollas E., Hardwidge, Philip R.

“…Type III secretion system effector proteins have primarily been characterized for their interactions with host cell proteins and their ability to disrupt host…”
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Arginine glycosylation regulates UDP-GlcNAc biosynthesis in Salmonella enterica by El Qaidi, Samir, Scott, Nichollas E., Hays, Michael P., Hardwidge, Philip R.

“…The Salmonella enterica  SseK1 protein is a type three secretion system effector that glycosylates host proteins during infection on specific arginine residues…”
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Vitamin B6 Biosynthesis Pathway in Streptococcus pneumoniae Is Controlled by Pyridoxal 5′-Phosphate and the Transcription Factor PdxR and Has an Impact on Ear Infection by El Qaidi, Samir, Yang, Jun, Zhang, Jing-Ren, Metzger, Dennis W, Bai, Guangchun

“…Vitamin B6 is an essential cofactor for a large number of enzymes in both prokaryotes and eukaryotes. In this study, we characterized the pyridoxal…”
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ABC cloning: An efficient, simple, and rapid restriction/ligase-free method by El Qaidi, Samir, Hardwidge, Philip R.

“…[Display omitted] DNA cloning remains the primary step before the further investigation of gene function. Restriction enzyme-based cloning methods are still…”
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The T3SS Effector Protease NleC Is Active within Citrobacter rodentium by Hasan, Md Kamrul, El Qaidi, Samir, Hardwidge, Philip R.

“…Whether type III secretion system (T3SS) effector proteins encoded by Gram-negative bacterial pathogens have intra-bacterial activities is an important and…”
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Loss to gain: pseudogenes in microorganisms, focusing on eubacteria, and their biological significance by Yang, Yi, Wang, Pengzhi, Qaidi, Samir El, Hardwidge, Philip R., Huang, Jinlin, Zhu, Guoqiang

“…Pseudogenes are defined as “non-functional” copies of corresponding parent genes. The cognition of pseudogenes continues to be refreshed through accumulating…”
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NleB/SseK effectors from Citrobacter rodentium, Escherichia coli, and Salmonella enterica display distinct differences in host substrate specificity by El Qaidi, Samir, Chen, Kangming, Halim, Adnan, Siukstaite, Lina, Rueter, Christian, Hurtado-Guerrero, Ramon, Clausen, Henrik, Hardwidge, Philip R.

“…Many Gram-negative bacterial pathogens use a syringe-like apparatus called a type III secretion system to inject virulence factors into host cells. Some of…”
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Salmonella T3SS effector SseK1 arginine-glycosylates the two-component response regulator OmpR to alter bile salt resistance by Hasan, Md Kamrul, Scott, Nichollas E., Hays, Michael P., Hardwidge, Philip R., El Qaidi, Samir

“…Type III secretion system (T3SS) effector proteins are primarily recognized for binding host proteins to subvert host immune response during infection. Besides…”
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An intra-bacterial activity for a T3SS effector by El Qaidi, Samir, Scott, Nichollas E., Hays, Michael P., Geisbrecht, Brian V., Watkins, Shelby, Hardwidge, Philip R.

“…Many Gram-negative bacterial pathogens interact with mammalian cells by using type III secretion systems (T3SS) to inject virulence proteins into host cells. A…”
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Rapid detection of flagellated and non-flagellated Salmonella by targeting the common flagellar hook gene flgE by Yang, Yi, Wang, Pengzhi, Xia, Pengpeng, Yang, Bin, Dai, Peng, Hong, Tianqi, Li, Jing, Meng, Xia, El Qaidi, Samir, Zhu, Guoqiang

“…Salmonella spp. can cause animal and human salmonellosis. In this study, we established a simple method to detect all Salmonella species by amplifying a…”
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NleB/SseK-catalyzed arginine-glycosylation and enteropathogen virulence are finely tuned by a single variable position contiguous to the catalytic machinery by García-García, Ana, Hicks, Thomas, El Qaidi, Samir, Zhu, Congrui, Hardwidge, Philip R, Angulo, Jesús, Hurtado-Guerrero, Ramon

“…NleB/SseK effectors are arginine-GlcNAc-transferases expressed by enteric bacterial pathogens that modify host cell proteins to disrupt signaling pathways…”
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Structural basis for arginine glycosylation of host substrates by bacterial effector proteins by Park, Jun Bae, Kim, Young Hun, Yoo, Youngki, Kim, Juyeon, Jun, Sung-Hoon, Cho, Jin Won, El Qaidi, Samir, Walpole, Samuel, Monaco, Serena, García-García, Ana A., Wu, Miaomiao, Hays, Michael P., Hurtado-Guerrero, Ramon, Angulo, Jesus, Hardwidge, Philip R., Shin, Jeon-Soo, Cho, Hyun-Soo

“…The bacterial effector proteins SseK and NleB glycosylate host proteins on arginine residues, leading to reduced NF-κB-dependent responses to infection…”
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High-Throughput Screening for Bacterial Glycosyltransferase Inhibitors by El Qaidi, Samir, Zhu, Congrui, McDonald, Peter, Roy, Anuradha, Maity, Pradip Kumar, Rane, Digamber, Perera, Chamani, Hardwidge, Philip R

“…The enteropathogenic and enterohemorrhagic NleB proteins as well as the SseK proteins are type III secretion system effectors that function as…”
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YM155 Inhibits NleB and SseK Arginine Glycosyltransferase Activity by Zhu, Congrui, El Qaidi, Samir, McDonald, Peter, Roy, Anuradha, Hardwidge, Philip R

“…The type III secretion system effector proteins NleB and SseK are glycosyltransferases that glycosylate protein substrates on arginine residues. We conducted…”
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Repurposing Avasimibe to Inhibit Bacterial Glycosyltransferases by Hasan, Md Kamrul, El Qaidi, Samir, McDonald, Peter, Roy, Anuradha, Hardwidge, Philip R

“…We are interested in identifying and characterizing small molecule inhibitors of bacterial virulence factors for their potential use as anti-virulence…”
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The phosphotransferase VanU represses expression of four qrr genes antagonizing VanO-mediated quorum-sensing regulation in Vibrio anguillarum by WEBER, Barbara, LINDELL, Kristoffer, QAIDI, Samir Ei, HJERDE, Erik, WILLASSEN, Nils-Peder, MILTON, Debra L

“…Vibrio anguillarum utilizes quorum sensing to regulate stress responses required for survival in the aquatic environment. Like other Vibrio species, V…”
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SseL Deubiquitinates RPS3 to Inhibit Its Nuclear Translocation by Wu, Miaomiao, El Qaidi, Samir, Hardwidge, Philip R

“…Many Gram-negative bacterial pathogens use type III secretion systems to deliver virulence proteins (effectors) into host cells to counteract innate immunity…”
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Switching Control of Expression of ptsG from the Mlc Regulon to the NagC Regulon by EL QAIDI, Samir, PLUMBRIDGE, Jacqueline

“…ERRATUM ( vol. 190 , p. 5733 ) Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious…”
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The Vitamin B 6 Biosynthesis Pathway in Streptococcus pneumoniae Is Controlled by Pyridoxal 5′-Phosphate and the Transcription Factor PdxR and Has an Impact on Ear Infection by El Qaidi, Samir, Yang, Jun, Zhang, Jing-Ren, Metzger, Dennis W., Bai, Guangchun

“…ABSTRACT Vitamin B 6 is an essential cofactor for a large number of enzymes in both prokaryotes and eukaryotes. In this study, we characterized the pyridoxal…”
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Fructose-1-kinase has pleiotropic roles in Escherichia coli by Weeramange, Chamitha, Menjivar, Cindy, O’Neil, Pierce T., El Qaidi, Samir, Harrison, Kelly S., Meinhardt, Sarah, Bird, Cole L., Sreenivasan, Shwetha, Hardwidge, Philip R., Fenton, Aron W., Hefty, P. Scott, Bose, Jeffrey L., Swint-Kruse, Liskin

“…In Escherichia coli, the master transcription regulator catabolite repressor activator (Cra) regulates >100 genes in central metabolism. Cra binding to DNA is…”
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