Metabolic syndrome in Tunisian psoriatic patients: prevalence and determinants

Background A significant association between psoriasis and the metabolic syndrome (MetS) has been frequently reported. Objective The aim of this study was to specify the main factors that determine the MetS in psoriatic Tunisian patients. Methods A case–control study has included 164 psoriatic pa...

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Bibliographic Details
Published in:	Journal of the European Academy of Dermatology and Venereology Vol. 25; no. 6; pp. 705 - 709
Main Authors:	Mebazaa, A, El Asmi, M, Zidi, W, Zayani, Y, Cheikh Rouhou, R, El Ounifi, S, Kanoun, F, Mokni, M, Osman, A Ben, Feki, M, Slimane, H, Kaabachi, N
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-06-2011
Subjects:	abdominal obesity Adult Aged Case-Control Studies Cholesterol, HDL - blood Female high-density lipoprotein cholesterol Humans Hypertension Logistic Models Male metabolic syndrome Metabolic Syndrome - complications Metabolic Syndrome - epidemiology Middle Aged Obesity, Abdominal Odds Ratio Prevalence psoriasis Psoriasis - complications Sex Factors Tunisia - epidemiology
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Summary:	Background A significant association between psoriasis and the metabolic syndrome (MetS) has been frequently reported. Objective The aim of this study was to specify the main factors that determine the MetS in psoriatic Tunisian patients. Methods A case–control study has included 164 psoriatic patients and 216 controls. Results The prevalence of MetS was higher in cases than in controls but without statistical differences [35.5% vs. 30.8%, odds ratio (OR): 1.39 CI: 0.88–2.18; P = 0.095]. According to gender, the prevalence of MetS was significantly increased only in psoriatic women (47.4% vs. 30%, OR: 1.89, CI: 1.11–3.21; P = 0.01). A multiple logistic regression, considering the effect of age, and gender, showed that the prevalence of MetS was significantly higher in cases than in controls (OR: 1.73, CI: 1.06–2.82; P = 0.03). MetS components analysed seperately showed a significantly higher prevalence of decreased high‐density lipoprotein cholesterol (HDLc) (60.9% vs. 35.9%, OR: 2.77, CI: 1.8–4.27, P < 0.001) and for increased hypertension (50% vs. 40%, OR: 1.48, CI: 0.97–2.257, P = 0.04) in psoriatic patients. According to gender, HDLc was significantly decreased in both genders (male: OR: 2.075, CI: 1.24–3.47, P = 0.004; female: OR: 3.58, CI: 2.07–6.19, P < 0.0001), while hypertension was increased only in psoriatic men (OR: 2.09, CI: 1.24–3.51, P = 0.004) and abdominal obesity only in psoriatic women (OR: 2.31, CI: 1.30–4.11, P = 0.002). Conclusion Decreased HDLc is the main biological abnormality that characterized MetS in Tunisian psoriatic patients. Moreover, contrary to men, psoriatic women have shown a significantly higher prevalence of MetS, which is, in addition to decreased HDLc, mainly attributed to abdominal obesity.
Bibliography:	istex:2A51E5B8A6427C04EC8A9D2DDF458E521CDFB033 ArticleID:JDV3856 ark:/67375/WNG-MX2FW5QW-X Conflict of interest None declared. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0926-9959 1468-3083
DOI:	10.1111/j.1468-3083.2010.03856.x