Lipid peroxidation/antioxidant activity in patients with alopecia areata

Background Aetiopathogenesis of alopecia areata (AA) is not fully understood and many factors have been assumed. Oxidant/antioxidant disequilibrium has been proposed with controversies between results. Objectives The aim of this study was to determine lipid peroxidation/antioxidant activity in pat...

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Bibliographic Details
Published in:	Journal of the European Academy of Dermatology and Venereology Vol. 25; no. 4; pp. 403 - 408
Main Authors:	Abdel Fattah, NSA, Ebrahim, AA, El Okda, ES
Format:	Journal Article
Language:	English
Published:	Oxford, UK Blackwell Publishing Ltd 01-04-2011
Subjects:	Adult alopecia areata Alopecia Areata - metabolism Antioxidants - metabolism Case-Control Studies Female Humans Lipid Peroxidation Male malondialdehyde Malondialdehyde - metabolism oxidative stress reactive oxygen species superoxide dismutase Superoxide Dismutase - metabolism
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Summary:	Background Aetiopathogenesis of alopecia areata (AA) is not fully understood and many factors have been assumed. Oxidant/antioxidant disequilibrium has been proposed with controversies between results. Objectives The aim of this study was to determine lipid peroxidation/antioxidant activity in patients with AA and to determine its clinical significance. Methods Fifty non‐obese patients with AA and 50 age‐, gender‐ and body mass index‐matched controls (25 patients with severe grade acne vulgaris representative of an oxidative stress condition and 25 healthy volunteers), were included. Levels of malondialdehyde (MDA), indicator of lipid peroxidation and antioxidant activity of superoxide dismutase (SOD), were spectrophotometrically measured in blood from all subjects and in scalp tissues from 10 patients with AA. Results No significant differences in MDA levels and SOD activity existed between patients with AA and those with acne. However, significantly higher MDA levels and lower SOD activity were found in patients with AA compared with healthy controls. Within patients with AA, lipid peroxidation/antioxidant parameters showed significant differences with disease duration, pattern and extent of lesions. Significant positive correlations also existed between tissue and blood SOD activity and between tissue and blood MDA levels of the 10 studied patients with AA. Conclusions Increased lipid peroxidation and defective SOD activity exist in patients with AA. Addition of drugs with antioxidative effects seems to be valuable in treatment.
Bibliography:	ArticleID:JDV3799 ark:/67375/WNG-M1CC1GGM-3 istex:BB4C2E43B180DFF43D8D6CF6813D683BBD6E7DC6 Conflict of interest None. Funding sources None. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0926-9959 1468-3083
DOI:	10.1111/j.1468-3083.2010.03799.x