Search Results - "El Moghrabi, Soumaya"

The Bone Morphogenetic Protein Signaling Inhibitor LDN-193189 Enhances Metastasis Development in Mice by Vollaire, Julien, Machuca-Gayet, Irma, Lavaud, Jonathan, Bellanger, Aurélie, Bouazza, Lamia, El Moghrabi, Soumaya, Treilleux, Isabelle, Coll, Jean-Luc, Peyruchaud, Olivier, Josserand, Véronique, Cohen, Pascale A

“…Breast cancer with bone metastasis is essentially incurable with current anticancer therapies. The bone morphogenetic protein (BMP) pathway is an attractive…”
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The diuretic torasemide does not prevent aldosterone-mediated mineralocorticoid receptor activation in cardiomyocytes by Gravez, Basile, Tarjus, Antoine, Jimenez-Canino, Ruben, El Moghrabi, Soumaya, Messaoudi, Smail, Alvarez de la Rosa, Diego, Jaisser, Frederic

“…Aldosterone binds to the mineralocorticoid receptor (MR) and exerts pleiotropic effects beyond enhancing renal sodium reabsorption. Excessive mineralocorticoid…”
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Tissue kallikrein permits early renal adaptation to potassium load by Moghrabi, Soumaya El, Houillier, Pascal, Picard, Nicolas, Sohet, Fabien, Wootla, Bharath, Bloch-Faure, May, Leviel, Françoise, Cheval, Lydie, Frische, Sebastian, Meneton, Pierre, Eladari, Dominique, Chambrey, Régine, Giebisch, Gerhard

“…Tissue kallikrein (TK) is a serine protease synthetized in renal tubular cells located upstream from the collecting duct where renal potassium balance is…”
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The myeloid mineralocorticoid receptor controls inflammatory and fibrotic responses after renal injury via macrophage interleukin-4 receptor signaling by Barrera-Chimal, Jonatan, Estrela, Gabriel R, Lechner, Sebastian M, Giraud, Sébastien, El Moghrabi, Soumaya, Kaaki, Shiem, Kolkhof, Peter, Hauet, Thierry, Jaisser, Frédéric

“…Acute kidney injury induced by ischemia/reperfusion is an independent risk factor for chronic kidney disease. Macrophage recruitment plays an essential role…”
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Smooth Muscle Cell Mineralocorticoid Receptors Are Mandatory for Aldosterone–Salt to Induce Vascular Stiffness by Galmiche, Guillaume, Pizard, Anne, Gueret, Alexandre, El Moghrabi, Soumaya, Ouvrard-Pascaud, Antoine, Berger, Stefan, Challande, Pascal, Jaffe, Iris Z., Labat, Carlos, Lacolley, Patrick, Jaisser, Frédéric

“…Arterial stiffness is recognized as a risk factor for many cardiovascular diseases. Aldosterone via its binding to and activation of the mineralocorticoid…”
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The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice by Leviel, Françoise, Hübner, Christian A, Houillier, Pascal, Morla, Luciana, El Moghrabi, Soumaya, Brideau, Gaëlle, Hassan, Hatim, Hatim, Hassan, Parker, Mark D, Kurth, Ingo, Kougioumtzes, Alexandra, Sinning, Anne, Pech, Vladimir, Riemondy, Kent A, Miller, R Lance, Hummler, Edith, Shull, Gary E, Aronson, Peter S, Doucet, Alain, Wall, Susan M, Chambrey, Régine, Eladari, Dominique

“…Regulation of sodium balance is a critical factor in the maintenance of euvolemia, and dysregulation of renal sodium excretion results in disorders of altered…”
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Deletion of mineralocorticoid receptors in smooth muscle cells blunts renal vascular resistance following acute cyclosporine administration by Amador, Cristian A, Bertocchio, Jean-Philippe, Andre-Gregoire, Gwennan, Placier, Sandrine, Duong Van Huyen, Jean-Paul, El Moghrabi, Soumaya, Berger, Stefan, Warnock, David G, Chatziantoniou, Christos, Jaffe, Iris Z, Rieu, Philippe, Jaisser, Frederic

“…Calcineurin inhibitors such as cyclosporine A (CsA) are still commonly used after renal transplantation, despite CsA--induced nephrotoxicity (CIN), which is…”
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A new pancreatic adenocarcinoma‐derived organoid model of acquired chemoresistance to FOLFIRINOX: First insight of the underlying mechanisms by Hadj Bachir, Elsa, Poiraud, Charles, Paget, Sonia, Stoup, Nicolas, El Moghrabi, Soumaya, Duchêne, Belinda, Jouy, Nathalie, Bongiovanni, Antonino, Tardivel, Meryem, Weiswald, Louis‐Bastien, Vandepeutte, Marie, Beugniez, César, Escande, Fabienne, Leteurtre, Emmanuelle, Poulain, Laurent, Lagadec, Chann, Pigny, Pascal, Jonckheere, Nicolas, Renaud, Florence, Truant, Stephanie, Van Seuningen, Isabelle, Vincent, Audrey

“…Background Information Although improvements have been made in the management of pancreatic adenocarcinoma (PDAC) during the past 20 years, the prognosis of…”
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Role of smooth muscle cell mineralocorticoid receptor in vascular tone by Tarjus, Antoine, Belozertseva, Ekaterina, Louis, Huguette, El Moghrabi, Soumaya, Labat, Carlos, Lacolley, Patrick, Jaisser, Frédéric, Galmiche, Guillaume

“…Identification of the mineralocorticoid receptor (MR) in the vasculature (i.e., endothelial and smooth muscle cells) raised the question of its role in…”
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The Mineralocorticoid Receptor on Smooth Muscle Cells Promotes Tacrolimus-Induced Renal Injury in Mice by Figueroa, Stefanny M, Bertocchio, Jean-Philippe, Nakamura, Toshifumi, El-Moghrabi, Soumaya, Jaisser, Frédéric, Amador, Cristián A

“…Tacrolimus (Tac) is a calcineurin inhibitor commonly used as an immunosuppressor after solid organ transplantation. However, Tac may induce hypertension,…”
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Defective ENaC Processing and Function in Tissue Kallikrein-deficient Mice by Picard, Nicolas, Eladari, Dominique, El Moghrabi, Soumaya, Planès, Carole, Bourgeois, Soline, Houillier, Pascal, Wang, Qing, Burnier, Michel, Deschenes, Georges, Knepper, Mark A., Meneton, Pierre, Chambrey, Régine

“…An inverse relationship exists between urinary tissue kallikrein (TK) excretion and blood pressure in humans and rodents. In the kidney TK is synthesized in…”
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Nonsteroidal Mineralocorticoid Receptor Antagonist Finerenone Protects Against Acute Kidney Injury–Mediated Chronic Kidney Disease: Role of Oxidative Stress by Lattenist, Lionel, Lechner, Sebastian M, Messaoudi, Smail, Le Mercier, Alan, El Moghrabi, Soumaya, Prince, Sonia, Bobadilla, Norma A, Kolkhof, Peter, Jaisser, Frédéric, Barrera-Chimal, Jonatan

“…Acute kidney injury induced by ischemia/reperfusion (IR) is a frequent complication in hospitalized patients. Mineralocorticoid receptor antagonism has shown…”
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NGAL is a Novel Target in Hypertension by Modulating the NCC-Mediated Renal Na Balance by Bonnard, Benjamin, El Moghrabi, Soumaya, Ueda, Kohei, Lattenist, Lionel, Soulie, Matthieu, López-Andrés, Natalia, Xhaard, Constance, Shimosawa, Tatsuo, Rossignol, Patrick, Jaisser, Frédéric

“…The expression of NGAL/lcn2 (neutrophil gelatinase-associated lipocalin) is directly modulated by mineralocorticoid receptor activation but its role in blood…”
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Neutrophil Gelatinase-Associated Lipocalin from immune cells is mandatory for aldosterone-induced cardiac remodeling and inflammation by Buonafine, Mathieu, Martínez-Martínez, Ernesto, Amador, Cristian, Gravez, Basile, Ibarrola, Jaime, Fernández-Celis, Amaya, El Moghrabi, Soumaya, Rossignol, Patrick, López-Andrés, Natalia, Jaisser, Frédéric

“…Immune system activation is involved in cardiovascular (CV) inflammation and fibrosis, following activation of the mineralocorticoid receptor (MR). We…”
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Sulfenic Acid Modification of Endothelin B Receptor is Responsible for the Benefit of a Nonsteroidal Mineralocorticoid Receptor Antagonist in Renal Ischemia by Barrera-Chimal, Jonatan, Prince, Sonia, Fadel, Fouad, El Moghrabi, Soumaya, Warnock, David G, Kolkhof, Peter, Jaisser, Frédéric

“…AKI is associated with high mortality rates and the development of CKD. Ischemia/reperfusion (IR) is an important cause of AKI. Unfortunately, there is no…”
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Neutrophil Gelatinase–Associated Lipocalin, a Novel Mineralocorticoid Biotarget, Mediates Vascular Profibrotic Effects of Mineralocorticoids by Tarjus, Antoine, Martínez-Martínez, Ernesto, Amador, Cristian, Latouche, Céline, El Moghrabi, Soumaya, Berger, Thorsten, Mak, Tak W, Fay, Renaud, Farman, Nicolette, Rossignol, Patrick, Zannad, Faiez, López-Andrés, Natalia, Jaisser, Frédéric

“…Activation of the mineralocorticoid receptor has been shown to be deleterious in cardiovascular diseases (CVDs). We have recently shown that lipocalin 2…”
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ERRα Expression in Bone Metastases Leads to an Exacerbated Antitumor Immune Response by Bouchet, Mathilde, Lainé, Alexandra, Boyault, Cyril, Proponnet-Guerault, Mathilde, Meugnier, Emmanuelle, Bouazza, Lamia, Kan, Casina W S, Geraci, Sandra, El-Moghrabi, Soumaya, Hernandez-Vargas, Hector, Benetollo, Claire, Yoshiko, Yuji, Duterque-Coquillaud, Martine, Clézardin, Philippe, Marie, Julien C, Bonnelye, Edith

“…Bone is the most common metastatic site for breast cancer. Although the estrogen-related receptor alpha (ERRα) has been implicated in breast cancer cell…”
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ERRα expression in bone metastases leads to an exacerbated anti-tumor immune response by Bouchet, Mathilde, Lainé, Alexandra, Boyault, Cyril, Proponnet-Guerault, Mathilde, Meugnier, Emmanuelle, Bouazza, Lamia, Kan, Casina E, Geraci, Sandra, El-Moghrabi, Soumaya, Hernandez-Vargas, Hector, Benetollo, Claire, Yoshiko, Yuji, Duterque-Coquillaud, Martine, Clézardin, Philippe E, Marie, Julien C., Bonnelye, Edith E

“…Bone is the most common metastatic site for breast cancer. Although the estrogen-related receptor alpha (ERRα) has been implicated in breast cancer cell…”
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Abstract P298: Finerenone Protects Against the Acute and Chronic Consequences of Renal Ischemia/reperfusion Injury by Barrera-Chimal, Jonatan, Le Mercier, Alan, El-Moghrabi, Soumaya, Kolkhof, Peter, Jaisser, Frederic

“…Abstract only Introduction: One of the most common causes of acute kidney injury (AKI) is renal ischemia/reperfusion (IR). Mineralocorticoid receptor (MR)…”
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Neutrophil Gelatinase-Associated Lipocalin Is a Novel Mineralocorticoid Target in the Cardiovascular System by Latouche, Celine, El Moghrabi, Soumaya, Messaoudi, Smail, Nguyen Dinh Cat, Aurélie, Hernandez-Diaz, Ivan, Alvarez de la Rosa, Diego, Perret, Claudine, López Andrés, Natalia, Rossignol, Patrick, Zannad, Faiez, Farman, Nicolette, Jaisser, Frederic

“…Mineralocorticoid receptor (MR) activation may be deleterious to the cardiovascular system, and MR antagonists improve morbidity and mortality of patients with…”
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