Comparison of monocyte distribution width and Procalcitonin as diagnostic markers for sepsis: Meta-analysis of diagnostic test accuracy studies

Comparison of monocyte distribution width and Procalcitonin as diagnostic markers for sepsis: Meta-analysis of diagnostic test accuracy studies

We aimed to perform a meta-analysis to find out whether PCT and MDW could be used as accurate diagnostic markers for sepsis. We searched PUBMED, WOS, and SCOPUS databases. Inclusion criteria were any observational or clinical trials that compared monocyte Distribution Width [MDW] with Procalcitonin...

Full description

Saved in:
Bibliographic Details
Published in:PloS one Vol. 18; no. 8; p. e0288203
Main Authors: Motawea, Karam R, S Rozan, Samah, Elsayed Talat, Nesreen, H Elhalag, Rowan, Mohammed Reyad, Sarraa, Chebl, Pensée, Swed, Sarya, Sawaf, Bisher, Hadeel Alfar, Hadeel, Farwati, Amr, Sabbagh, Bana, M Madera, Esperance, El Metaafy, Amro, J Barboza, Joshuan, Sah, Ranjit, Aiash, Hani
Format: Journal Article
Language:English
Published: United States Public Library of Science 03-08-2023
Subjects:
Accuracy
Analysis
Biological markers
Biology and Life Sciences
Biomarkers
Case reports
Clinical trials
COVID-19
Diabetes
Diagnosis
Diagnostic tests
Emergency medical care
Emergency medical services
Health aspects
Infections
Medical diagnosis
Medicine and Health Sciences
Meta-analysis
Monocytes
Mortality
Observational studies
Patients
Physical Sciences
Procalcitonin
Research and Analysis Methods
Risk factors
Sepsis
Software
Statistical analysis
Subgroups
United States
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We aimed to perform a meta-analysis to find out whether PCT and MDW could be used as accurate diagnostic markers for sepsis. We searched PUBMED, WOS, and SCOPUS databases. Inclusion criteria were any observational or clinical trials that compared monocyte Distribution Width [MDW] with Procalcitonin [PCT] as diagnostic markers in a patient with sepsis. Case reports, editorials, conference abstracts, and animal studies were excluded. RevMan software [5.4] was used to perform the meta-analysis. After the complete screening, 5 observational studies were included in the meta-analysis. The total number of patients included in the meta-analysis in the sepsis group is 565 and 781 in the control group. The pooled analysis between the sepsis group and controls showed a statistically significant association between sepsis and increased levels of MDW and PCT [MD = 3.94, 95% CI = 2.53 to 5.36, p-value < 0.00001] and [MD = 9.29, 95% CI = 0.67 to 17.91, p-value = 0.03] respectively. Moreover, the subgroup analysis showed that the p-value of MDW levels [< 0.00001] is more significant than the p-value of PCT levels = 0.03, the p-value between the two subgroups [< 0.00001]. Additionally, the overall ROC Area for MDW [0.790] > the overall ROC Area for PCT [0.760]. Our study revealed a statistically significant association between sepsis and increased MDW and PCT levels compared with controls and the overall ROC Area for MDW is higher than the overall ROC Area for PCT, indicating that the diagnostic accuracy of MDW is higher than PCT.MDW can be used as a diagnostic marker for sepsis patients in the emergency department. More multicenter studies are needed to support our findings.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
content type line 23
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0288203