Search Results - "El Menshawe, Shahira F."

A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo characterization by Salem, Heba F., El-Menshawe, Shahira F., Khallaf, Rasha A., Rabea, Yasmine K.

“…Poor bioavailability of drugs via oral route is the greatest challenge facing drug formulation. To overcome this obstacle, transdermal route was commonly used…”
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Transdermal delivery of fluvastatin sodium via tailored spanlastic nanovesicles: mitigated Freund's adjuvant-induced rheumatoid arthritis in rats through suppressing p38 MAPK signaling pathway by El Menshawe, Shahira F., Nafady, Mohamed M., Aboud, Heba M., Kharshoum, Rasha M., Elkelawy, Asmaa Mohammed M. Hussein, Hamad, Doaa S.

“…The current study aimed to encapsulate fluvastatin sodium (FVS), a member of the statins family possessing pleiotropic effects in rheumatoid arthritis (RA),…”
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Optimization and Appraisal of Nintedanib-Loaded Mixed Polymeric Micelles as a Potential Nanovector for Non-Invasive Pulmonary Fibrosis Mitigation by Aboud, Heba M, El Menshawe, Shahira F, Mohammed, Nada H, Tulbah, Alaa S, Ali, Adel A

“…Nintedanib (NTD), a triple tyrosine kinase receptor inhibitor, is the recommended first-line tackling option for idiopathic pulmonary fibrosis (IPF)…”
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Innovative pulmonary targeting of terbutaline sulfate-laded novasomes for non-invasive tackling of asthma: statistical optimization and comparative in vitro/in vivo evaluation by Elkomy, Mohammed H., El Menshawe, Shahira F., Kharshoum, Rasha M., Abdeltwab, Amany M., Hussein, Raghda R. S., Hamad, Doaa S., Alsalahat, Izzeddin, Aboud, Heba M.

“…Asthma represents a globally serious non-communicable ailment with significant public health outcomes for both pediatrics and adults triggering vast morbidity…”
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Loratadine bioavailability via buccal transferosomal gel: formulation, statistical optimization, in vitro/in vivo characterization, and pharmacokinetics in human volunteers by Elkomy, Mohammed H., El Menshawe, Shahira F., Abou-Taleb, Heba A., Elkarmalawy, Marwa H.

“…Loratadine (LTD) is an antihistaminic drug that suffers limited solubility, poor oral bioavailability (owing to extensive first-pass metabolism), and highly…”
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Repurposing celecoxib for colorectal cancer targeting via pH-triggered ultra-elastic nanovesicles: Pronounced efficacy through up-regulation of Wnt/β-catenin pathway in DMH-induced tumorigenesis by El Menshawe, Shahira F., Shalaby, Khaled, Elkomy, Mohammed H., Aboud, Heba M., Ahmed, Yasmin M., Abdelmeged, Abdelmeged A., Elkarmalawy, Marwa, Abou Alazayem, Mahmoud A., El Sisi, Amani M.

“…Celecoxib (CLX), a selective inhibitor for cyclooxygenase 2 (COX-2), has manifested potential activity against diverse types of cancer. However, low…”
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Nanotransfersomes of carvedilol for intranasal delivery: formulation, characterization and in vivo evaluation by Aboud, Heba M, Ali, Adel Ahmed, El-Menshawe, Shahira F, Elbary, Ahmed Abd

“…Development of carvedilol-loaded transfersomes for intranasal administration to overcome poor nasal permeability and hepatic first pass effect so as to enhance…”
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Development, Optimization, and In Vitro/In Vivo Characterization of Enhanced Lipid Nanoparticles for Ocular Delivery of Ofloxacin: the Influence of Pegylation and Chitosan Coating by Eid, Hussein M., Elkomy, Mohammed H., El Menshawe, Shahira F., Salem, Heba F.

“…This study aims to investigate whether modification of solid lipid nanoparticles (SLNs) with chitosan (CTS) and polyethylene glycol (PEG) coatings enhances…”
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A novel nanogel loaded with chitosan decorated bilosomes for transdermal delivery of terbutaline sulfate: artificial neural network optimization, in vitro characterization and in vivo evaluation by El Menshawe, Shahira F., Aboud, Heba M., Elkomy, Mohammed H., Kharshoum, Rasha M., Abdeltwab, Amany M.

“…The objective of the present work was to formulate, optimize, and evaluate transdermal terbutaline sulfate (TBN)-loaded bilosomes (BLS) in gel, compared to…”
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Nanosized soy phytosome-based thermogel as topical anti-obesity formulation: an approach for acceptable level of evidence of an effective novel herbal weight loss product by El-Menshawe, Shahira F, Ali, Adel A, Rabeh, Mohamed A, Khalil, Nermeen M

“…Herbal supplements are currently available as a safer alternative to manage obesity, which has become a rising problem over the recent years. Many chemical…”
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Development, Optimization, and Evaluation of Carvedilol-Loaded Solid Lipid Nanoparticles for Intranasal Drug Delivery by Aboud, Heba M., El komy, Mohammed H., Ali, Adel A., El Menshawe, Shahira F., Abd Elbary, Ahmed

“…Carvedilol, a beta-adrenergic blocker, suffers from poor systemic availability (25%) due to first-pass metabolism. The aim of this work was to improve…”
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Formulation and evaluation of meloxicam niosomes as vesicular carriers for enhanced skin delivery by El-Menshawe, Shahira F., Hussein, Amal K.

“…Context: Skin delivery of Meloxicam (MX) offers several advantages over the oral route which is associated with potential side effects. Objectives: The aim of…”
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Development of a nanogel formulation for transdermal delivery of tenoxicam: a pharmacokinetic-pharmacodynamic modeling approach for quantitative prediction of skin absorption by Elkomy, Mohammed H., El Menshawe, Shahira F., Eid, Hussein M., Ali, Ahmed M. A.

“…This study investigates potentials of solid lipid nanoparticles (SLN)-based gel for transdermal delivery of tenoxicam (TNX) and describes a…”
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Skin permeation enhancement of nicotinamide through using fluidization and deformability of positively charged ethosomal vesicles: A new approach for treatment of atopic eczema by El-Menshawe, Shahira F., Sayed, Ossama M., Abou-Taleb, Heba A., El Tellawy, Nada

“…For the treatment of atopic eczema, the drug penetration of the relevant skin layers is considered to be a major scientific concern. In this study, a new…”
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Correction to: A novel transdermal nanoethosomal gel of lercanidipine HCl for treatment of hypertension: optimization using Box-Benkhen design, in vitro and in vivo characterization by Salem, Heba F., El-Menshawe, Shahira F., Khallaf, Rasha A., Rabea, Yasmine K.

“…In the original article, there are errors in Tables 2 and 6. Following are the corrected tables…”
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A novel transdermal nanoethosomal gel of betahistine dihydrochloride for weight gain control: in-vitro and in-vivo characterization by El-Menshawe, Shahira F, Ali, Adel Ahmed, Halawa, Abdelkhalk Ali, Srag El-Din, Ahmed Sg

“…Betahistine dihydrochloride (BDH) is a histamine analog used to control weight gain, with short elimination half-life and gastric irritation as side effects…”
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Betahistine dihydrochloride transdermal delivery via optimized thermosensitive gels: percutaneous absorption evaluation using rat growth as a biomarker by Elkomy, Mohammed Hassan, El-Menshawe, Shahira F., Ali, Adel Ahmed, Halawa, Abdelkhalik Ali, El-Din, Ahmed S. G. Srag

“…The aim of this study was to develop and optimize a betahistine dihydrochloride (BH) thermoreversible bioadhesive gel intended for transdermal delivery. The…”
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Comparison of Three Different Concentrations of Levobupivacaine for Epidural Labor Analgesia: Clinical Effect and Pharmacokinetic Profile by El-Shaarawy, Ahmed Mostafa, Asfour, Mohamed S., Rashwan, Doaa A., Amer, Mahmoud M., El-Menshawe, Shahira F., Elkomy, Mohammed H.

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Transfersomal nanovesicles for nose-to-brain delivery of ofloxacin for better management of bacterial meningitis: Formulation, optimization by Box-Behnken design, characterization and in vivo pharmacokinetic study by Eid, Hussein M., Elkomy, Mohammed H., El Menshawe, Shahira F., Salem, Heba F.

“…This study aims to formulate a nanosystem of ofloxacin (OFLOX) for nose-to-brain delivery to enhance brain accumulation and improve management of bacterial…”
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The use of new quinazolinone derivative and doxorubicin loaded solid lipid nanoparticles in reversing drug resistance in experimental cancer cell lines: A systematic study by El-Menshawe, Shahira F., Sayed, Ossama M., Abou Taleb, Heba A., Saweris, Mina A., Zaher, Dana M., Omar, Hany A.

“…The aim of this research is to study the feasibility of using carnauba wax as a new carrier for anticancer agents to deliver doxorubicin (DOX) as a model drug…”
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