Search Results - "El Marrouni, Abdellatif"

Pharmacological validation of dihydrofolate reductase as a drug target in Mycobacterium abscessus by Aragaw, Wassihun Wedajo, Negatu, Dereje A, Bungard, Christopher J, Dartois, Véronique A, Marrouni, Abdellatif El, Nickbarg, Elliott B, Olsen, David B, Warrass, Ralf, Dick, Thomas

“…The drug development pipeline is poorly populated, with particularly few validated target-lead couples to initiate drug discovery. Trimethoprim, an inhibitor…”
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Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus by Madani, Abdeldjalil, Negatu, Dereje A., El Marrouni, Abdellatif, Miller, Randy R., Boyce, Christopher W., Murgolo, Nicholas, Bungard, Christopher J., Zimmerman, Matthew D., Dartois, Véronique, Gengenbacher, Martin, Olsen, David B., Dick, Thomas

“…Tricyclic pyrrolopyrimidines (TPPs) are a new class of antibacterials inhibiting the ATPase of DNA gyrase. TPP8, a representative of this class, is active…”
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Potent targeted activator of cell kill molecules eliminate cells expressing HIV-1 by Balibar, Carl J, Klein, Daniel J, Zamlynny, Beata, Diamond, Tracy L, Fang, Zhiyu, Cheney, Carol A, Kristoff, Jan, Lu, Meiqing, Bukhtiyarova, Marina, Ou, Yangsi, Xu, Min, Ba, Lei, Carroll, Steven S, El Marrouni, Abdellatif, Fay, John F, Forster, Ashley, Goh, Shih Lin, Gu, Meigang, Krosky, Daniel, Rosenbloom, Daniel I S, Sheth, Payal, Wang, Deping, Wu, Guoxin, Zebisch, Matthias, Zhao, Tian, Zuck, Paul, Grobler, Jay, Hazuda, Daria J, Howell, Bonnie J, Converso, Antonella

“…Antiretroviral therapy inhibits HIV-1 replication but is not curative due to establishment of a persistent reservoir after virus integration into the host…”
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Metal-Free Addition of Alkyl Bromides to Access 3,3-Disubstituted Quinoxalinones Enabled by Visible-Light Photoredox Catalysis by Liao, Jennie, Hunter, David N., Oloyede, Ugochinyere Nancy, McLaughlin, Joseph W., Wang, Cheng, El Marrouni, Abdellatif

“…A metal-free addition of unactivated alkyl bromides to quinoxalin-2­(1H)-ones is described. This method enables the construction of valuable 3,3-disubstituted…”
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Dose Number as a Tool to Guide Lead Optimization for Orally Bioavailable Compounds in Drug Discovery by Wuelfing, W. Peter, El Marrouni, Abdellatif, Lipert, Maya P, Daublain, Pierre, Kesisoglou, Filippos, Converso, Antonella, Templeton, Allen C

“…Small molecule developability challenges have been well documented over the last two decades. One of these critical developability parameters is aqueous…”
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High-Throughput Photo- and Electrochemical sp 2 -sp 3 Cross-Electrophile Coupling to Access Novel Tedizolid Analogs by Montero Bastidas, Jose Raul, L'Heureux, Scott, Liu, Wenbin, Lee, Ken, El Marrouni, Abdellatif

“…The development of practical synthetic protocols integrating novel technologies may enable rapid and broad exploration of chemical space in medicinal chemistry…”
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High-Throughput Photo- and Electrochemical sp2–sp3 Cross-Electrophile Coupling to Access Novel Tedizolid Analogs by Montero Bastidas, Jose Raul, L’Heureux, Scott, Liu, Wenbin, Lee, Ken, El Marrouni, Abdellatif

“…The development of practical synthetic protocols integrating novel technologies may enable rapid and broad exploration of chemical space in medicinal chemistry…”
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Synthesis of C6-Substituted Purine Nucleoside Analogues via Late-Stage Photoredox/Nickel Dual Catalytic Cross-Coupling by Perkins, James J, Shurtleff, Valerie W, Johnson, Alayna M, El Marrouni, Abdellatif

“…Nucleoside analogues have been and continue to be extremely important compounds in drug discovery. Despite the significant effort dedicated to their synthesis,…”
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Total Synthesis of Putative 11-epi-Lyngbouilloside Aglycon by Kolleth, Amandine, Gebauer, Julian, ElMarrouni, Abdelatif, Lebeuf, Raphael, Prévost, Céline, Brohan, Eric, Arseniyadis, Stellios, Cossy, Janine

“…We report here the total synthesis of 11-epi-lyngbouilloside aglycon. Our strategy features a Boeckman-type esterification followed by a RCM to form the…”
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