Search Results - "El Mansari, Mostafa"

Serotonin and beyond: therapeutics for major depression by Blier, Pierre, El Mansari, Mostafa

“…The serotonin (5-HT, 5-hydroxytryptamine) system has been implicated in the pathogenesis of major depressive disorder (MDD). The case for its contribution to…”
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Effects of sustained serotonin reuptake inhibition on the firing of dopamine neurons in the rat ventral tegmental area by Dremencov, Eliyahu, PhD, El Mansari, Mostafa, PhD, Blier, Pierre, MD, PhD

“…Background Selective serotonin (5-HT) reuptake inhibitors (SSRIs) are efficacious in depression because of their ability to increase 5-HT neurotransmission…”
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Long-term administration of the dopamine D3/2 receptor agonist pramipexole increases dopamine and serotonin neurotransmission in the male rat forebrain by Chernoloz, Olga, BSc Pharm, El Mansari, Mostafa, PhD, Blier, Pierre, MD, PhD

“…Background Long-term administration of the dopamine (DA) D2-like (D3/2) receptor agonist pramipexole (PPX) has been previously found to desensitize D2…”
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Altered response to the selective serotonin reuptake inhibitor escitalopram in mice heterozygous for the serotonin transporter: an electrophysiological and neurochemical study by Guiard, Bruno P., Mansari, Mostafa El, Murphy, Dennis L., Blier, Pierre

“…A serotonin (5-HT) transporter (5-HTT; SERT) polymorphism has been associated with depressive states and poor responses to selective serotonin reuptake…”
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Serotonin-2B receptor antagonism increases the activity of dopamine and glutamate neurons in the presence of selective serotonin reuptake inhibition by Hamati, Rami, El Mansari, Mostafa, Blier, Pierre

“…Previous research has implicated the serotonin-2B (5-HT ) receptor as a possible contributor to the antidepressant-like response. Aripiprazole has been…”
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Repeated but Not Single Administration of Ketamine Prolongs Increases of the Firing Activity of Norepinephrine and Dopamine Neurons by Iro, Chidiebere M, Hamati, Rami, El Mansari, Mostafa, Blier, Pierre

“…Abstract Background Clinical studies have shown that the rapid antidepressant effect of the glutamate N-methyl-D-aspartate receptor antagonist ketamine…”
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Wistar Kyoto rats exhibit decreased serotonin neuronal firing and increased norepinephrine burst activity but dampened hippocampal α2-adrenoceptor sensitivity by El Mansari, Mostafa, Hamoudeh, Rami, Daniels, Stephen, Blier, Pierre

“…Background: Wistar Kyoto (WKY) rats manifest abnormalities in the function of monoamine receptors and transporters, as well as levels of these…”
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Ketamine promptly normalizes excess norepinephrine and enhances dopamine neuronal activity in Wistar Kyoto rats by Daniels, Stephen, El Mansari, Mostafa, Hamoudeh, Rami, Blier, Pierre

“…Ketamine acts primarily by blocking the N-methyl-D-aspartate (NMDA) receptor at the phencyclidine site. The rapid antidepressant properties of ketamine were…”
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Cross-talk between dopaminergic and noradrenergic systems in the rat ventral tegmental area, locus ceruleus, and dorsal hippocampus by Guiard, Bruno P, El Mansari, Mostafa, Blier, Pierre

“…A decreased central dopaminergic and/or noradrenergic transmission is believed to be involved in the pathophysiology of depression. It is known that dopamine…”
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Long-term administration of cariprazine increases locus coeruleus noradrenergic neurons activity and serotonin1A receptor neurotransmission in the hippocampus by El Mansari, Mostafa, Ebrahimzadeh, Mohammad, Hamati, Rami, Iro, Chidibere M, Farkas, Bence, Kiss, Béla, Adham, Nika, Blier, Pierre

“…Background: Cariprazine, the novel dopamine (DA) D3-preferring D3/D2 and serotonin (5-HT)1A receptor partial agonist, has activity as an adjunctive therapy in…”
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Impact of subanesthetic doses of ketamine on AMPA-mediated responses in rats: An in vivo electrophysiological study on monoaminergic and glutamatergic neurons by El Iskandrani, Kareem S, Oosterhof, Chris A, El Mansari, Mostafa, Blier, Pierre

“…The rapid antidepressant action of a subanesthetic dose of ketamine in treatment-resistant patients represents the most striking recent breakthrough in the…”
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Distinct electrophysiological effects of paliperidone and risperidone on the firing activity of rat serotonin and norepinephrine neurons by DREMENCOV, Eliyahu, EL MANSARI, Mostafa, BLIER, Pierre

“…Paliperidone (9-OH-risperidone) is the main metabolite of the atypical antipsychotic risperidone. While both drugs are potent dopamine (D)2 antagonists, they…”
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Brexpiprazole Alters Monoaminergic Systems following Repeated Administration: an in Vivo Electrophysiological Study by Oosterhof, Chris A., Mansari, Mostafa El, Bundgaard, Christoffer, Blier, Pierre

“…Background: Brexpiprazole was recently approved as adjunctive therapy for depression and treatment of schizophrenia in adults. To complement results from a…”
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Pharmacological Blockade of 5-HT7 Receptors as a Putative Fast Acting Antidepressant Strategy by MNIE-FILALI, Ouissame, FAURE, Céline, BLIER, Pierre, HADDJERI, Nasser, LAMBAS-SENAS, Laura, MANSARI, Mostafa Ei, BEIBLIDIA, Hassina, GONDARD, Elise, ETIEVANT, Adeline, SCARNA, Hélène, DIDIER, Anne, BEROD, Anne

“…Current antidepressants still display unsatisfactory efficacy and a delayed onset of therapeutic action. Here we show that the pharmacological blockade of…”
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Effects of acute and long-term administration of escitalopram and citalopram on serotonin neurotransmission : an in vivo electrophysiological study in rat brain by EL MANSARI, Mostafa, SANCHEZ, Connie, CHOUVET, Guy, RENAUD, Bernard, HADDJERI, Nasser

“…The present study was undertaken to compare the acute and long-term effects of escitalopram and citalopram on rat brain 5-HT neurotransmission, using…”
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Relevance of Norepinephrine–Dopamine Interactions in the Treatment of Major Depressive Disorder by El Mansari, Mostafa, Guiard, Bruno P., Chernoloz, Olga, Ghanbari, Ramez, Katz, Noam, Blier, Pierre

“…Central dopaminergic and noradrenergic systems play essential roles in controlling several forebrain functions. Consequently, perturbations of these…”
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Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons by Guiard, Bruno P., Chenu, Franck, Mansari, Mostafa El, Blier, Pierre

“…Triple reuptake inhibitors represent a potential new class of antidepressant drugs that block norepinephrine (NE), dopamine (DA) and serotonin…”
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Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area by Chenu, Franck, Mansari, Mostafa El, Blier, Pierre

“…Monoamine oxidase inhibitors (MAOIs) exert their antidepressant action by increasing the function of the serotonin (5-HT), norepinephrine and dopamine (DA)…”
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Restoration of Serotonin Neuronal Firing Following Long-Term Administration of Bupropion but Not Paroxetine in Olfactory Bulbectomized Rats by Mansari, Mostafa El, Manta, Stella, Oosterhof, Chris, El Iskandrani, Kareem S., Chenu, Franck, Shim, Stacey, Blier, Pierre

“…Background: Olfactory bulbectomized rats generally manifest many of the neurochemical, physiological, and behavioral features of major depressive disorder in…”
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Allosteric modulation of the effect of escitalopram, paroxetine and fluoxetine: in-vitro and in-vivo studies by Mansari, Mostafa El, Wiborg, Ove, Mnie-Filali, Ouissame, Benturquia, Nadia, Sánchez, Connie, Haddjeri, Nasser

“…Clinical and preclinical studies have shown that the effect of citalopram on serotonin (5-HT) reuptake inhibition and its antidepressant activity resides in…”
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