Search Results - "El Hamd, Mohamed A."
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Application of quality-by-design for adopting an environmentally green fluorogenic determination of benoxinate hydrochloride in eye drops and artificial aqueous humour
Published in Scientific reports (26-05-2023)“…Herein, a sensitive and selective spectrofluorimetric method has been developed for the determination of the ocular local anesthetic benoxinate hydrochloride…”
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Design, Synthesis, Biological Evaluation, and Molecular Dynamics Studies of Novel Lapatinib Derivatives
Published in Pharmaceuticals (Basel, Switzerland) (28-12-2022)“…Co-expression of the epidermal growth factor receptor (EGFR, also known as ErbB1) and human epidermal growth factor receptor 2 (HER2) has been identified as a…”
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Formulation development of lipid polymer hybrid nanoparticles of doxorubicin and its in-vitro, in-vivo and computational evaluation
Published in Frontiers in pharmacology (07-02-2023)“…The purpose of this study was to assess the parameters of doxorubicin (DOX) loaded lipid polymer hybrid nanoparticles (LPHNs) formulation development, and then…”
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Microenvironment improvement protocol for the sensitive spectrofluorimetric determination of an hepatitis C virus antiviral (Simeprevir): application to human plasma
Published in Luminescence (Chichester, England) (01-05-2020)“…Simeprevir (SPV) is a powerful antihepatitis C virus agent that was newly introduced into the pharmaceutical market. We here established and validated an easy,…”
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Self-ratiometric fluorescence approach based on plant extract-assisted synthesized silver nanoparticles for the determination of vanillin
Published in Mikrochimica acta (1966) (01-01-2024)“…The current study designed and applied a novel self-ratiometric fluorescent nanosensor composed of green-synthesized silver nanoparticles (Ag-NPs) to determine…”
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Current and Future Prospective of Injectable Hydrogels-Design Challenges and Limitations
Published in Pharmaceuticals (Basel, Switzerland) (18-03-2022)“…Injectable hydrogels (IHs) are smart biomaterials and are the most widely investigated and versatile technologies, which can be either implanted or inserted…”
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A specific turn-on fluorescence probe for determination of nitazoxanide based on feasible oxidation reaction with hypochlorite: Applying cobalt ferrite nanoparticles for pre-concentration and extraction of its metabolite from real urine samples
Published in Journal of pharmaceutical and biomedical analysis (20-09-2022)“…Nitazoxanide is an antimicrobial compound that was originally developed as an antiprotozoal drug. Recently nitazoxanide has been identified as broad-spectrum…”
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Nano-scale multi-spectroscopic analysis of the anti-fibromyalgia drug pregabalin based on dihydropyridine ring formation with sustainability and whiteness evaluation
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (15-01-2025)“…[Display omitted] •Multiple-spectroscopic assay of the non-chromophoric zwitterionic drug pregabalin.•Employing Hantzsch’s one-pot cyclization reaction in…”
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Facile Integration of Hanztsch's Switch-Off/On Modeled Fluorogenic Probe for Feasible Tagging and Tracking of the Midodrine Drug in Different Matrices; First Evaluation of the Method's Greenness, Whiteness, Blueness, Quantum Yield, and Tablets' Content Homogeneity
Published in Journal of fluorescence (05-08-2024)“…The proposed investigation follows a certain methodology to guarantee that the procedure employed is sustainable and green. It is noteworthy to mention that…”
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Application of isoindole fluorophore formation for determination of linagliptin in the sole and co-formulated tablets: Application for plasma assay and content uniformity testing
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (15-04-2023)“…[Display omitted] •The current approach describes an innovative method for linagliptin assay.•The assay is based on using o-phthalaldehyde as a fluorogenic…”
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Microwave-assisted synthesis, spectroscopic characterization, and biological evaluation of fused thieno[2,3-d]pyrimidines as potential anti-cancer agents targeting EGFRWT and EGFRT790M
Published in Molecular diversity (01-04-2023)“…Epidermal growth factor receptor (EGFR) is a transmembrane protein tyrosine kinase that is usually overexpressed in many types of cancers. In the present…”
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Green Synthesis of Silver Nanoparticles Incorporated Aromatherapies Utilized for Their Antioxidant and Antimicrobial Activities against Some Clinical Bacterial Isolates
Published in Bioinorganic chemistry and applications (2022)“…There is a need to synthesize eco-friendly nanoparticles with more effective and potent antibacterial activities. A green and cost-effective method for the…”
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Polymerized β-Cyclodextrin-Based Injectable Hydrogel for Sustained Release of 5-Fluorouracil/Methotrexate Mixture in Breast Cancer Management: In Vitro and In Vivo Analytical Validations
Published in Pharmaceutics (08-04-2022)“…An inclusion complexation, between polymerized β-cyclodextrin and cholesterol end-capping branched polyethylene glycol, was utilized for constructing a…”
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Integration of a facile sustainable resonance Rayleigh scattering switchable-based system for feasible determination of centrophenoxine, a nootropic and antioxidant agent; application to crude materials and dosage forms
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (15-05-2024)“…A simple scheming summarizing the planned method and giving overall picture about the article concerns, CPX-Erythrosine B coupled product suggested mechanism,…”
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Two Versatile Pencil Graphite-Polymer Sensor Electrodes Coupled with Potentiometry and Potentiometric Titration Methods: Profiling Determinations of Vitamin V in Tablets and Urine Samples
Published in Sensors (Basel, Switzerland) (24-11-2022)“…Herein, we developed a new pencil graphite ion-selective electrode strategy for the broadly used erectile dysfunction medication, sildenafil citrate (SC,…”
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Self-assembling Organogels Loaded with Tenoxicam for Local Intensive Pain and Inflammation Cure: In Vitro and In Vivo Correlation
Published in AAPS PharmSciTech (23-01-2024)“…Due to tenoxicam (TX)’s poor aqueous solubility (0.072 mg/ml), it is poorly absorbable in the GIT, and the long-term oral administration of TX may cause severe…”
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Development of GBRT Model as a Novel and Robust Mathematical Model to Predict and Optimize the Solubility of Decitabine as an Anti-Cancer Drug
Published in Molecules (Basel, Switzerland) (01-09-2022)“…The efficient production of solid-dosage oral formulations using eco-friendly supercritical solvents is known as a breakthrough technology towards developing…”
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Tailoring of Rosuvastatin Calcium and Atenolol Bilayer Tablets for the Management of Hyperlipidemia Associated with Hypertension: A Preclinical Study
Published in Pharmaceutics (01-08-2022)“…Hyperlipidemia is still the leading cause of heart disease in patients with hypertension. The purpose of this study is to make rosuvastatin calcium (ROS) and…”
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A Novel Approach for the Availability and Ocular Delivery of Tenoxicam Potassium: Synthesis, Characterization, and In Vivo Application
Published in AAPS PharmSciTech (26-01-2023)“…Tenoxicam (TX) is a non-steroidal anti-inflammatory agent that can be used to control pain in various ophthalmic lesions like cataracts, refractive surgery,…”
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Sustainable PVP-Capped Silver Nanoparticles as a Free-Standing Nanozyme Sensor for Visual and Spectrophotometric Detection of Hg2+ in Water Samples: A Green Analytical Method
Published in Chemosensors (01-09-2022)“…In the proposed method, microwave-assist heating and AgNO3/trisodium citrate were used to create the polyvinylpyrrolidone-capped silver nanoparticles…”
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