Search Results - "El Haj, A.J."

Cyclic hydrostatic pressure stimulates enhanced bone development in the foetal chick femur in vitro by Henstock, J.R, Rotherham, M, Rose, J.B, El Haj, A.J

“…Abstract Mechanical loading of bone and cartilage in vivo results in the generation of cyclic hydrostatic forces as bone compression is transduced to fluid…”
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Evaluation of skeletal tissue repair, Part 2: Enhancement of skeletal tissue repair through dual-growth-factor-releasing hydrogels within an ex vivo chick femur defect model by Smith, E.L., Kanczler, J.M., Gothard, D., Roberts, C.A., Wells, J.A., White, L.J., Qutachi, O., Sawkins, M.J., Peto, H., Rashidi, H., Rojo, L., Stevens, M.M., El Haj, A.J., Rose, F.R.A.J., Shakesheff, K.M., Oreffo, R.O.C.

“…[Display omitted] There is an unmet need for improved, effective tissue engineering strategies to replace or repair bone damaged through disease or injury…”
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Nicotinic regulation of c- fos and osteopontin expression in human-derived osteoblast-like cells and human trabecular bone organ culture by Walker, L.M, Preston, M.R, Magnay, J.L, Thomas, P.B.M, El Haj, A.J

“…Long-term in vivo studies have highlighted smoking as a risk factor in postmenopausal osteoporosis, bone fracture incidence, and increased nonunion rates. In…”
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Chitosan microchannel scaffolds for tendon tissue engineering characterized using optical coherence tomography by Bagnaninchi, P O, Yang, Y, Zghoul, N, Maffulli, N, Wang, R K, Haj, A J El

“…Tendon tissue engineering requires the generation of a uniaxially orientated collagen type I matrix with several organization scales that confer mechanical…”
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CORRELATING CELL MORPHOLOGY AND OSTEOID MINERALIZATION RELATIVE TO STRAIN PROFILE FOR BONE TISSUE ENGINEERING APPLICATIONS by Wood, M.A, Yang, Y, Baas, E, Meredith, D.O, Richards, R.G, H. Kuiper, J, El Haj, A.J

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Correlating cell morphology and osteoid mineralization relative to strain profile for bone tissue engineering applications by Wood, M.A, Yang, Y, Baas, E, Meredith, D.O, Richards, R.G, Kuiper, J.H, El Haj, A.J

“…A number of bone tissue engineering strategies use porous three-dimensional scaffolds in combination with bioreactor regimes. The ability to understand cell…”
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Hormonally-Regulated Expression of Voltage-Operated Ca2+ Channels in Osteocytic (MLO-Y4) Cells by Gu, Y., Preston, M.R., Magnay, J., El Haj, A.J., Publicover, S.J.

“…Voltage operated calcium channels (VOCCs) are important in stimulus-response coupling in osteoblasts. We have investigated the expression of VOCCs in the mouse…”
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Comparison of the variable loop regions of myosin heavy chain genes from Antarctic and temperate isopods by Holmes, J.M., Whiteley, N.M., Magnay, J.L., El Haj, A.J.

“…The evolutionary adaptations of functional genes to life at low temperatures are not well characterised in marine and fresh water invertebrates. Temperature…”
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Triggering the activation of Activin A type II receptor in human adipose stem cells towards tenogenic commitment using mechanomagnetic stimulation by Gonçalves, A.I., Rotherham, M., Markides, H., Rodrigues, M.T., Reis, R.L., Gomes, M.E., El Haj, A.J.

“…Stem cell therapies hold potential to stimulate tendon regeneration and homeostasis, which is maintained in response to the native mechanical environment…”
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Osteoblast: Osteoclast co-cultures on silk fibroin, chitosan and PLLA films by Jones, Gemma L, Motta, Antonella, Marshall, Mike J, El Haj, Alicia J, Cartmell, Sarah H

“…Abstract This study investigates the growth of a co-culture of osteoblasts and osteoclasts on four different types of degradable biomaterials with bone tissue…”
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Real-time and non-invasive measurements of cell mechanical behaviour with optical coherence phase microscopy by Gillies, D., Gamal, W., Downes, A., Reinwald, Y., Yang, Y., El Haj, A.J., Bagnaninchi, P.O.

“…•A new method to monitor the mechanical behaviour of cells is described.•Measurements are made in real-time and non-destructively.•The response of cells to…”
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Evaluation of skeletal tissue repair, Part 1: Assessment of novel growth-factor-releasing hydrogels in an ex vivo chick femur defect model by Smith, E.L., Kanczler, J.M., Gothard, D., Roberts, C.A., Wells, J.A., White, L.J., Qutachi, O., Sawkins, M.J., Peto, H., Rashidi, H., Rojo, L., Stevens, M.M., El Haj, A.J., Rose, F.R.A.J., Shakesheff, K.M., Oreffo, R.O.C.

“…[Display omitted] Current clinical treatments for skeletal conditions resulting in large-scale bone loss include autograft or allograft, both of which have…”
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Expression of voltage-operated Ca2+ channels in rat bone marrow stromal cells in vitro by PRESTON, M. R, EL HAJ, A. J, PUBLICOVER, S. J

“…The expression of voltage-operated Ca2+ currents (VOCCs) in bone marrow stromal cells cultured for 3-30 days has been studied by the use of the whole-cell…”
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The influence of hydrostatic pressure on tissue engineered bone development by Neßler, K.H.L., Henstock, J.R., El Haj, A.J., Waters, S.L., Whiteley, J.P., Osborne, J.M.

“…The hydrostatic pressure stimulation of an appropriately cell-seeded porous scaffold within a bioreactor is a promising method for engineering bone tissue…”
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Optimization of dynamic culture conditions: effects on biosynthetic activities of chondrocytes grown in collagen sponges by Freyria, A-M, Yang, Y, Chajra, H, Rousseau, C F, Ronzière, M-C, Herbage, D, El Haj, A J

“…Application of mechanical stimulation, using dynamic bioreactors, is considered an effective strategy to enhance cellular behavior in load-bearing tissues. In…”
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Linking functional molecular variation with environmental gradients: Myosin gene diversity in a crustacean broadly distributed across variable thermal environments by Rock, J., Magnay, J.L., Beech, S., El Haj, A.J., Goldspink, G., Lunt, D.H., Whiteley, N.M.

“…To investigate the molecular basis of temperature adaptation in natural populations we used the candidate gene approach, targeting the myosin heavy chain (…”
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FT-IR microspectroscopy as a tool to assess lung cancer cells response to chemotherapy by Sulé-Suso, J., Skingsley, D., Sockalingum, G.D., Kohler, A., Kegelaer, G., Manfait, M., El Haj, A.J.

“…Lung cancer is a disease associated with a poor prognosis. One of the reasons for this is the lack of effective treatment. Chemotherapy, together with surgery…”
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Characterisation of myosin heavy chain gene variants in the fast and slow muscle fibres of gammarid amphipods by Whiteley, N.M., Magnay, J.L., McCleary, S.J., Nia, S. Khazraee, El Haj, A.J., Rock, J.

“…Recent molecular work has revealed a large diversity of myosin heavy chain (MyHC) gene variants in the abdominal musculature of gammarid amphipods. An unusual…”
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Protein synthesis and specific dynamic action in crustaceans: effects of temperature by Whiteley, N.M., Robertson, R.F., Meagor, J., El Haj, A.J., Taylor, E.W.

“…Temperature influences the specific dynamic action (SDA), or rise in oxygen uptake rate after feeding, in eurythermal and stenothermal crustaceans by changing…”
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Molecular plasticity of muscle in response to temperature adaptation and acclimation in crustaceans by El Haj, A.J, Holmes, J.M

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