Search Results - "El Gamal, A"

Molecular targets and anticancer activity of quinoline-chalcone hybrids: literature review by Mohamed, Mamdouh F. A, Abuo-Rahma, Gamal El-Din A

“…α,β-Unsaturated chalcone moieties and quinoline scaffolds play an important role in medicinal chemistry, especially in the identification and development of…”
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In vitro inhibition and molecular docking of a new ciprofloxacin‐chalcone against SARS‐CoV‐2 main protease by Alaaeldin, Rania, Mustafa, Muhamad, Abuo‐Rahma, Gamal El‐Din A., Fathy, Moustafa

“…Background/Aim SARS‐CoV‐2 is one of the coronavirus families that emerged at the end of 2019. It infected the respiratory system and caused a pandemic…”
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Recent updates of fluoroquinolones as antibacterial agents by Ezelarab, Hend A. A., Abbas, Samar H., Hassan, Heba A., Abuo‐Rahma, Gamal El‐Din A.

“…Fluoroquinolones remain one of the most important kind of antibacterial agents used nowadays. The emergence of more virulent and resistant strains of bacteria…”
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A Personalized Computer-Aided Diagnosis System for Mild Cognitive Impairment (MCI) Using Structural MRI (sMRI) by El-Gamal, Fatma El-Zahraa A., Elmogy, Mohammed, Mahmoud, Ali, Shalaby, Ahmed, Switala, Andrew E., Ghazal, Mohammed, Soliman, Hassan, Atwan, Ahmed, Alghamdi, Norah Saleh, Barnes, Gregory Neal, El-Baz, Ayman

“…Alzheimer’s disease (AD) is a neurodegenerative disorder that targets the central nervous system (CNS). Statistics show that more than five million people in…”
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Ciprofloxacin Derivative‐Loaded Nanoparticles Synergize with Paclitaxel Against Type II Human Endometrial Cancer by Naguib, Youssef W., Alhaj‐Suliman, Suhaila O., Wafa, Emad I., Saha, Sanjib, Ebeid, Kareem, Mohammed, Hamada H. H., Abdel‐Rahman, Somaya A., Abuo‐Rahma, Gamal El‐Din A., Geary, Sean M., Salem, Aliasger K.

“…Combinations of chemotherapeutic agents comprise a clinically feasible approach to combat cancers that possess resistance to treatment. Type II endometrial…”
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Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors by Mohamed, Mamdouh F.A., Marzouk, Adel A., Nafady, Ayman, El-Gamal, Dalia A., Allam, Rasha M., Abuo-Rahma, Gamal El-Din A., El Subbagh, Hussein I., Moustafa, Amr H.

“…[Display omitted] •A novel series of aryl carboximidamides 4a-g and their cyclized 3-aryl-1,2,4-oxadiazoles 5a-g counterparts derived from indomethacin 1 were…”
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Potential repurposed SARS-CoV-2 (COVID-19) infection drugs by Abuo-Rahma, Gamal El-Din A, Mohamed, Mamdouh F. A, Ibrahim, Tarek S, Shoman, Mai E, Samir, Ebtihal, Abd El-Baky, Rehab M

“…The global outbreak of COVID-19 viral infection is associated with the absence of specific drug(s) for fighting this viral infection. About 10 million people…”
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Towards anticancer fluoroquinolones: A review article by Abdel‐Aal, Mohamed A. A., Abdel‐Aziz, Salah A., Shaykoon, Montaser Sh. A., Abuo‐Rahma, Gamal El‐Din A.

“…Different studies about the anticancer potential of several medically used antibacterial fluoroquinolones have been established. Fluoroquinolone derivatives,…”
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Synthesis and chemiluminescent characteristics of two new acridinium esters by Smith, Keith, Mu, Xiaojing, Li, Zhaoqiang, Woodhead, J Stuart, El-Hiti, Gamal A

“…Two new acridinium esters with a 2-(succinimidyloxycarbonyl)ethyl side arm, namely…”
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New 1,2,3-triazole linked ciprofloxacin-chalcones induce DNA damage by inhibiting human topoisomerase I& II and tubulin polymerization by Mohammed, Hamada H. H., Abd El-Hafeez, Amer Ali, Ebeid, Kareem, Mekkawy, Aml I., Abourehab, Mohammed A. S., Wafa, Emad I., Alhaj-Suliman, Suhaila O., Salem, Aliasger K., Ghosh, Pradipta, Abuo-Rahma, Gamal El-Din A., Hayallah, Alaa M., Abbas, Samar H.

“…A series of novel 1,2,3-triazole-linked ciprofloxacin-chalcones 4a-j were synthesised as potential anticancer agents. Hybrids 4a-j exhibited remarkable…”
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Discovery of novel thienoquinoline-2-carboxamide chalcone derivatives as antiproliferative EGFR tyrosine kinase inhibitors by Abdelbaset, Mahmoud S., Abdel-Aziz, Mohamed, Ramadan, Mohamed, Abdelrahman, Mostafa H., Abbas Bukhari, Syed Nasir, Ali, Taha F.S., Abuo-Rahma, Gamal El-Din A.

“…[Display omitted] •Novel thienoquinoline-2-carboxamide-chalcone derivatives.•Structural elucidation.•Good Antiproliferaive Activity.•EGFR-kinase…”
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Modulating impacts of quercetin/sitagliptin combination on streptozotocin-induced diabetes mellitus in rats by Eitah, Hebatollah E., Maklad, Yousreya A., Abdelkader, Noha F., Gamal el Din, Amina A., Badawi, Manal A., Kenawy, Sanaa A.

“…Since many diabetic patients require combination therapy, the use of herbal remedies with anti-diabetic activity represents a vital option in diabetes mellitus…”
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Preparation of a novel group of chemiluminescent N‐substituted acridinium esters by Smith, Keith, Mu, Xiaojing, Li, Zhaoqiang, Woodhead, J. Stuart, El‐Hiti, Gamal A.

“…Several novel N‐substituted acridinium esters 7–16 containing a 10‐methyl, 10‐dodecyl, or 10‐(ω‐[succinimidyloxycarbonyl]alkyl) group have been synthesized and…”
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In Vitro Anticancer Activity of Novel Ciprofloxacin Mannich Base in Lung Adenocarcinoma and High-Grade Serous Ovarian Cancer Cell Lines via Attenuating MAPK Signaling Pathway by Fawzy, Michael A, Abu-Baih, Rania H, Abuo-Rahma, Gamal El-Din A, Abdel-Rahman, Islam M, El-Sheikh, Azza A K, Nazmy, Maiiada H

“…Novel drugs are desperately needed in order to combat a significant challenge due to chemo-therapeutic resistance and bad prognosis. This research aimed to…”
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Synthesis, structure elucidation, and chemiluminescent activity of new 9‐substituted 10‐(ω‐(succinimidyloxycarbonyl)alkyl)acridinium esters by Smith, Keith, Mu, Xiaojing, Li, Zhaoqiang, Holland, Andy M., Woodhead, J. Stuart, El‐Hiti, Gamal A.

“…Several new acridinium esters 2–9 having their central acridinium ring bearing a 9‐(2,5‐dimethylphenoxycarbonyl), 9‐(2,6‐bis(trifluoromethyl)phenoxycarbonyl)…”
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Evaluation of clinical outcomes and efficacy of palonosetron and granisetron in combination with dexamethasone in Egyptian patients receiving highly emetogenic chemotherapy by A. Mahrous, Mohamed, A. El-Azab, Gamal, A. Tawfik, Hisham

“…Background Chemotherapy-induced nausea and vomiting (CINV) is considered one of the most serious adverse events affecting chemotherapy-receiving cancer…”
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Synthesis of 9‐(substituted phenoxycarbonyl)‐10‐methylacridinium trifluoromethanesulfonates: Effects of the leaving group on chemiluminescent properties by Smith, Keith, Holland, Andy M., Woodhead, J. Stuart, El‐Hiti, Gamal A.

“…Various 9‐(substituted phenoxycarbonyl)‐10‐methylacridinium trifluoromethanesulfonates possessing electron‐withdrawing substituents have been synthesized. The…”
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A decade's overview of 2‐aminothiophenes and their fused analogs as promising anticancer agents by Darwish, Donia G., El‐Sherief, Hany A. M., Abdel‐Aziz, Salah A., Abuo‐Rahma, Gamal El‐Din A.

“…Over the past decades, cancer has been a challenging domain for medicinal chemists as it is an international health concern. In association, small molecules…”
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Novel quinoline derivatives carrying nitrones/oximes nitric oxide donors: Design, synthesis, antiproliferative and caspase‐3 activation activities by Abdelbaset, Mahmoud S., Abdel‐Aziz, Mohamed, Abuo‐Rahma, Gamal El‐Din A., Abdelrahman, Mostafa H., Ramadan, Mohamed, Youssif, Bahaa G. M.

“…Novel quinoline derivatives carrying nitrones and oxime as nitric oxide donors were prepared and characterized using different spectroscopic techniques…”
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Effect of iron poly(acrylic acid-co-acrylamide) and melamine polyphosphate on the flammability properties of linear low-density polyethylene by Abdelkhalik, Aksam, Abdel-Hakim, A., Makhlouf, Ghada, El-Gamal, A. A.

“…Iron poly(acrylic acid-co-acrylamide) (FeAA) and melamine polyphosphate (MPP) were synthesized, characterized by FTIR and blended with linear low-density…”
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