Search Results - "El Achab, Rachid"

New Tacrine−Huperzine A Hybrids (Huprines):  Highly Potent Tight-Binding Acetylcholinesterase Inhibitors of Interest for the Treatment of Alzheimer's Disease by Camps, Pelayo, El Achab, Rachid, Morral, Jordi, Muñoz-Torrero, Diego, Badia, Albert, Baños, Josep Eladi, Vivas, Nuria María, Barril, Xavier, Orozco, Modesto, Luque, Francisco Javier

“…Several new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives (tacrine−huperzine A hybrids, huprines) have been synthesized and…”
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Huprine X is a novel high-affinity inhibitor of acetylcholinesterase that is of interest for treatment of Alzheimer's disease by Camps, P, Cusack, B, Mallender, W D, El Achab, R E, Morral, J, Muñoz-Torrero, D, Rosenberry, T L

“…Inhibitors of the enzyme acetylcholinesterase (AChE) slow and sometimes reverse the cognitive decline experienced by individuals with Alzheimer's disease…”
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Easy synthesis of 7-alkylbicyclo[3.3.1]non-6-en-3-ones by silica gel-promoted fragmentation of 3-alkyl-2-oxaadamant-1-yl mesylates by Camps, Pelayo, El Achab, Rachid, Font-Bardia, Merce`, Go¨rbig, Diana, Morral, Jordi, Mun˜oz-Torrero, Diego, Solans, Xavier, Simon, Montserrat

“…A synthesis of 7-alkylbicyclo[3.3.1]non-6-en-3-ones 4b-f and 4j, k by reaction of the corresponding 3-alkyl-2-oxaadamant-1-yl mesylates 3 with silica gel in…”
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Synthesis, in Vitro Pharmacology, and Molecular Modeling of Very Potent Tacrine−Huperzine A Hybrids as Acetylcholinesterase Inhibitors of Potential Interest for the Treatment of Alzheimer's Disease by Camps, Pelayo, El Achab, Rachid, Görbig, Diana Marina, Morral, Jordi, Muñoz-Torrero, Diego, Badia, Albert, Baños, Josep Eladi, Vivas, Nuria María, Barril, Xavier, Orozco, Modesto, Luque, Francisco Javier

“…Eleven new 12-amino-6,7,10,11-tetrahydro-7,11-methanocycloocta[b]quinoline derivatives [tacrine (THA)−huperzine A hybrids, rac-21−31] have been synthesized as…”
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New Syntheses of rac-Huperzine A and its rac-7-Ethyl-Derivative. Evaluation of Several Huperzine A Analogues as Acetylcholinesterase Inhibitors by Camps, Pelayo, Contreras, Joan, El Achab, Rachid, Morral, Jordi, Muñoz-Torrero, Diego, Font-Bardia, Mercè, Solans, Xavier, Badia, Albert, Vivas, Nuria M

“…rac-Huperzine A, its rac-7-ethyl-derivative and two regioisomeric analogues have been prepared through synthetic sequences involving the elaboration of the…”
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