Search Results - "El‐Zein, Randa A."

Identification of circulating tumor cells using 4‐color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low‐dose computed tomography–detected lung nodules by Katz, Ruth L., Zaidi, Tanweer M., Pujara, Deep, Shanbhag, Namita D., Truong, Duy, Patil, Shekhar, Mehran, Reza J., El‐Zein, Randa A., Shete, Sanjay S., Kuban, Joshua D.

“…Background Approximately one third of needle biopsies that are performed to rule out malignancy of indeterminate pulmonary nodules detected radiologically…”
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Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk by EL-ZEIN, Randa A, SCHABATH, Matthew B, ETZEL, Carol J, LOPEZ, Mirtha S, FRANKLIN, Jamey D, SPITZ, Margaret R

“…In this case-control study, we modified the cytokinesis-block micronucleus (CBMN) assay, an established biomarker for genomic instability, to evaluate…”
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Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era by Brothers, John F, Hijazi, Kahkeshan, Mascaux, Celine, El-Zein, Randa A, Spitz, Margaret R, Spira, Avrum

“…Lung cancer is the leading cause of cancer death worldwide in part due to our inability to identify which smokers are at highest risk and the lack of effective…”
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Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy by Kamdar, Kala Y., Krull, Kevin R., El-Zein, Randa A., Brouwers, Pim, Potter, Brian S., Harris, Lynnette L., Holm, Suzanne, Dreyer, ZoAnn, Scaglia, Fernando, Etzel, Carol J., Bondy, Melissa, Okcu, M. Fatih

“…Background Neurocognitive impairment occurs in 20–40% of childhood acute lymphoblastic leukemia (ALL) survivors, possibly mediated by folate depletion and…”
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Genetic predisposition to chronic obstructive pulmonary disease and/or lung cancer: important considerations when evaluating risk by El-Zein, Randa A, Young, Robert P, Hopkins, Raewyn J, Etzel, Carol J

“…Chronic obstructive pulmonary disease (COPD) is defined as a disease causing an airflow limitation that is not fully reversible. COPD is phenotypically complex…”
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Cytokinesis-Blocked Micronucleus Cytome Assay Biomarkers Identify Lung Cancer Cases Amongst Smokers by El-Zein, Randa A, Fenech, Michael, Lopez, Mirtha S, Spitz, Margaret R, Etzel, Carol J

“…The multi-endpoint cytokinesis-blocked micronucleus assay is used for assessing chromosome aberrations. We have recently reported that this assay is extremely…”
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Hodgkin disease risk: Role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes by Monroy, Claudia M., Cortes, Andrea C., Lopez, Mirtha S., D'Amelio Jr, Anthony M., Etzel, Carol J., Younes, Anas, Strom, Sara S., El-Zein, Randa A.

“…Inflammation is a critical component of cancer development. The clinical and pathological features of Hodgkin disease (HD) reflect an abnormal immunity that…”
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Chronic obstructive pulmonary disease among lung cancer-free smokers: The importance of healthy controls by Karpman, Michelle D., Eldridge, Ronald, Follis, Jack L., Etzel, Carol J., Shete, Sanjay, El-Zein, Randa A.

“…The prevalence of chronic obstructive pulmonary disease (COPD) in smokers enrolled as “healthy” controls in studies is 10–50%. The COPD status of ideal smoker…”
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Variants in folate pathway genes as modulators of genetic instability and lung cancer risk by Piskac-Collier, Amanda L., Monroy, Claudia, Lopez, Mirtha S., Cortes, Andrea, Etzel, Carol J., Greisinger, Anthony J., Spitz, Margaret R., El-Zein, Randa A.

“…Genetic instability plays a crucial role in cancer development. The genetic stability of the cell as well as DNA methylation status could be modulated by…”
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The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK by Abdel-Rahman, Sherif Z, El-Zein, Randa A

“…DNA repair plays a critical role in protecting the genome of the cell from the insults of cancer-causing agents such as those found in tobacco smoke. Reduced…”
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Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers by El-Zein, Randa A, Monroy, Claudia M, Cortes, Andrea, Spitz, Margaret R, Greisinger, Anthony, Etzel, Carol J

“…DNA repair capacity is an important determinant of susceptibility to cancer. The hOGG1 enzyme is crucial for repairing the 8-oxoguanine lesion that occurs…”
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Nickel potentiates the genotoxic effect of benzo[a]pyrene in Chinese hamster lung V79 cells by Deng, Cheng Z., Fons, Michael P., Rosenblatt, Judah, El-Zein, Randa A., Abdel-Rahman, Sherif Z., Albrecht, Thomas

“…The modulating effect of acute exposure to NiCl2 on the induction of chromosome aberrations by a model carcinogen, benzo[a]pyrene (B[a]P), was examined in…”
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Mitotic Spindle Apparatus Abnormalities in Chronic Obstructive Pulmonary Disease Cells: A Potential Pathway to Lung Cancer by Thaiparambil, Jose, Dong, Lingyun, Jasso, Diana, Huang, Jian-An, El-Zein, Randa A

“…Chronic obstructive pulmonary disease (COPD) is a long-term lung disease characterized by irreversible lung damage resulting in airflow limitation, abnormal…”
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Single nucleotide polymorphisms 5′ upstream the coding region of the NEIL2 gene influence gene transcription levels and alter levels of genetic damage by Kinslow, Carla J., El-Zein, Randa A., Hill, Courtney E., Wickliffe, Jeffrey K., Abdel-Rahman, Sherif Z.

“…NEIL2 (EC 4.2.99.18), a mammalian DNA glycosylase and ortholog of the bacterial Fpg/Nei, excises oxidized DNA lesions from bubble or single‐stranded…”
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Identification of Small and Non-Small Cell Lung Cancer Markers in Peripheral Blood Using Cytokinesis-Blocked Micronucleus and Spectral Karyotyping Assays by El-Zein, Randa A, Abdel-Rahman, Shereen, Santee, Kyle J, Yu, Robert, Shete, Sanjay

“…Small cell lung cancer (SCLC) is a highly aggressive form of lung cancer. There is an urgent need to develop tools to identify individuals at high risk of…”
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The cytokinesis-blocked micronucleus assay as a strong predictor of lung cancer: extension of a lung cancer risk prediction model by El-Zein, Randa A, Lopez, Mirtha S, D'Amelio, Jr, Anthony M, Liu, Mei, Munden, Reginald F, Christiani, David, Su, Li, Tejera-Alveraz, Paula, Zhai, Rihong, Spitz, Margaret R, Etzel, Carol J

“…There is an urgent need to improve lung cancer outcome by identifying and validating markers of risk. We previously reported that the cytokinesis-blocked…”
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The cytokinesis-blocked micronucleus assay as a novel biomarker for selection of lung cancer screening participants by El-Zein, Randa A., Etzel, Carol J., Munden, Reginald F.

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Differential mutagen sensitivity of peripheral blood lymphocytes from smokers and nonsmokers: Effect of human cytomegalovirus infection by Albrecht, Thomas, Deng, Cheng Zong, Abdel-Rahman, Sherif Z., Fons, Michael, Cinciripini, Paul, El-Zein, Randa A.

“…We used the mutagen sensitivity assay to test the hypothesis that human cytomegalovirus (HCMV) infection modifies the sensitivity of cells to genetic damage…”
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Variability in human sensitivity to 1,3-butadiene: Influence of the allelic variants of the microsomal epoxide hydrolase gene by Abdel-Rahman, Sherif Z., El-Zein, Randa A., Ammenheuser, Marinel M., Yang, Zhen, Stock, Thomas H., Morandi, Maria, Ward Jr, Jonathan B.

“…The carcinogenic effects of 1,3‐butadiene (BD), a chemical widely used in the rubber industry, are thought to be due to its epoxide metabolites. In humans,…”
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Evaluating the effects of genetic variants of DNA repair genes using cytogenetic mutagen sensitivity approaches by Abdel-Rahman, Sherif Z., El-Zein, Randa A.

“…Mutagen sensitivity, measured in short-term cultures of peripheral blood lymphocytes by cytogenetic endpoints, is an indirect measure for DNA repair capacity…”
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