Search Results - "El‐Zein, Randa"

Identification of circulating tumor cells using 4‐color fluorescence in situ hybridization: Validation of a noninvasive aid for ruling out lung cancer in patients with low‐dose computed tomography–detected lung nodules by Katz, Ruth L., Zaidi, Tanweer M., Pujara, Deep, Shanbhag, Namita D., Truong, Duy, Patil, Shekhar, Mehran, Reza J., El‐Zein, Randa A., Shete, Sanjay S., Kuban, Joshua D.

“…Background Approximately one third of needle biopsies that are performed to rule out malignancy of indeterminate pulmonary nodules detected radiologically…”
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Bridging the clinical gaps: genetic, epigenetic and transcriptomic biomarkers for the early detection of lung cancer in the post-National Lung Screening Trial era by Brothers, John F, Hijazi, Kahkeshan, Mascaux, Celine, El-Zein, Randa A, Spitz, Margaret R, Spira, Avrum

“…Lung cancer is the leading cause of cancer death worldwide in part due to our inability to identify which smokers are at highest risk and the lack of effective…”
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Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells by Thaiparambil, Jose, Amara, Chandra S., Sen, Subrata, Putluri, Nagireddy, El‐Zein, Randa

“…Background Unlike normal cells, cancer cells frequently have multiple centrosomes that can cluster to form bipolar mitotic spindles and allow for successful…”
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Integrative metabolomics and transcriptomics analysis reveals novel therapeutic vulnerabilities in lung cancer by Thaiparambil, Jose, Dong, Jianrong, Grimm, Sandra L., Perera, Dimuthu, Ambati, Chandra Shekar R., Putluri, Vasanta, Robertson, Matthew J., Patel, Tajhal D., Mistretta, Brandon, Gunaratne, Preethi H., Kim, Min P., Yustein, Jason T., Putluri, Nagireddy, Coarfa, Cristian, El‐Zein, Randa

“…Background Non‐small cell lung cancer (NSCLC) comprises the majority (~85%) of all lung tumors, with lung adenocarcinoma (LUAD) and squamous cell carcinoma…”
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Genomic and expression analysis of microdissected inflammatory breast cancer by Woodward, Wendy A., Krishnamurthy, Savitri, Yamauchi, Hideko, El-Zein, Randa, Ogura, Dai, Kitadai, Eri, Niwa, Shin-ichiro, Cristofanilli, Massimo, Vermeulen, Peter, Dirix, Luc, Viens, Patrice, van Laere, Steve, Bertucci, François, Reuben, James M., Ueno, Naoto T.

“…Inflammatory breast cancer (IBC) is a unique clinical entity characterized by rapid onset of erythema and swelling of the breast often without an obvious…”
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Inflammatory breast cancer appearance at presentation is associated with overall survival by Balema, Wintana, Liu, Diane, Shen, Yu, El‐Zein, Randa, Debeb, Bisrat G., Kai, Megumi, Overmoyer, Beth, Miller, Kathy D., Le‐Petross, Huong T., Ueno, Naoto T., Woodward, Wendy A.

“…Background Inflammatory breast cancer (IBC) is a clinical diagnosis. Here, we examined the association of a “classic” triad of clinical signs, swollen involved…”
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Folate pathway polymorphisms predict deficits in attention and processing speed after childhood leukemia therapy by Kamdar, Kala Y., Krull, Kevin R., El-Zein, Randa A., Brouwers, Pim, Potter, Brian S., Harris, Lynnette L., Holm, Suzanne, Dreyer, ZoAnn, Scaglia, Fernando, Etzel, Carol J., Bondy, Melissa, Okcu, M. Fatih

“…Background Neurocognitive impairment occurs in 20–40% of childhood acute lymphoblastic leukemia (ALL) survivors, possibly mediated by folate depletion and…”
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Cytokinesis-blocked micronucleus assay as a novel biomarker for lung cancer risk by EL-ZEIN, Randa A, SCHABATH, Matthew B, ETZEL, Carol J, LOPEZ, Mirtha S, FRANKLIN, Jamey D, SPITZ, Margaret R

“…In this case-control study, we modified the cytokinesis-block micronucleus (CBMN) assay, an established biomarker for genomic instability, to evaluate…”
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Rapid method for determination of DNA repair capacity in human peripheral blood lymphocytes amongst smokers by El-Zein, Randa A, Monroy, Claudia M, Cortes, Andrea, Spitz, Margaret R, Greisinger, Anthony, Etzel, Carol J

“…DNA repair capacity is an important determinant of susceptibility to cancer. The hOGG1 enzyme is crucial for repairing the 8-oxoguanine lesion that occurs…”
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Hodgkin disease risk: Role of genetic polymorphisms and gene-gene interactions in inflammation pathway genes by Monroy, Claudia M., Cortes, Andrea C., Lopez, Mirtha S., D'Amelio Jr, Anthony M., Etzel, Carol J., Younes, Anas, Strom, Sara S., El-Zein, Randa A.

“…Inflammation is a critical component of cancer development. The clinical and pathological features of Hodgkin disease (HD) reflect an abnormal immunity that…”
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Genetic predisposition to chronic obstructive pulmonary disease and/or lung cancer: important considerations when evaluating risk by El-Zein, Randa A, Young, Robert P, Hopkins, Raewyn J, Etzel, Carol J

“…Chronic obstructive pulmonary disease (COPD) is defined as a disease causing an airflow limitation that is not fully reversible. COPD is phenotypically complex…”
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Chronic obstructive pulmonary disease among lung cancer-free smokers: The importance of healthy controls by Karpman, Michelle D., Eldridge, Ronald, Follis, Jack L., Etzel, Carol J., Shete, Sanjay, El-Zein, Randa A.

“…The prevalence of chronic obstructive pulmonary disease (COPD) in smokers enrolled as “healthy” controls in studies is 10–50%. The COPD status of ideal smoker…”
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Cytokinesis-Blocked Micronucleus Cytome Assay Biomarkers Identify Lung Cancer Cases Amongst Smokers by El-Zein, Randa A, Fenech, Michael, Lopez, Mirtha S, Spitz, Margaret R, Etzel, Carol J

“…The multi-endpoint cytokinesis-blocked micronucleus assay is used for assessing chromosome aberrations. We have recently reported that this assay is extremely…”
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Variants in folate pathway genes as modulators of genetic instability and lung cancer risk by Piskac-Collier, Amanda L., Monroy, Claudia, Lopez, Mirtha S., Cortes, Andrea, Etzel, Carol J., Greisinger, Anthony J., Spitz, Margaret R., El-Zein, Randa A.

“…Genetic instability plays a crucial role in cancer development. The genetic stability of the cell as well as DNA methylation status could be modulated by…”
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Evaluation of Digital Thermal Monitoring as a Tool to Assess Perioperative Vascular Reactivity by Schier, Robert, Marcus, Hanke E, Mansur, Eduardo, Lei, Xiudong, El-Zein, Randa, Mehran, Reza, Purugganan, Ron, Heir, Jagtar Singh, Riedel, Bernhard, Gottumukkala, Vijaya

“…Aim: The inflammatory response following tissue injury after major surgery is known to affect endothelial function and vascular reactivity. In this study we…”
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The 399Gln polymorphism in the DNA repair gene XRCC1 modulates the genotoxic response induced in human lymphocytes by the tobacco-specific nitrosamine NNK by Abdel-Rahman, Sherif Z, El-Zein, Randa A

“…DNA repair plays a critical role in protecting the genome of the cell from the insults of cancer-causing agents such as those found in tobacco smoke. Reduced…”
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Effect of Benzo[a]Pyrene on Spindle Misorientation and Fidelity of Chromosome Segregation in Lung Epithelial BEAS-2B Cells by Thaiparambil, Jose, Mansour, Oula, El-Zein, Randa

“…Abstract Benzo[a]pyrene (B[a]P) is an environmental carcinogen found in tobacco smoke. It leads to high levels of DNA adducts in the lungs of cigarette smokers…”
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Mitotic Spindle Apparatus Abnormalities in Chronic Obstructive Pulmonary Disease Cells: A Potential Pathway to Lung Cancer by Thaiparambil, Jose, Dong, Lingyun, Jasso, Diana, Huang, Jian-An, El-Zein, Randa A

“…Chronic obstructive pulmonary disease (COPD) is a long-term lung disease characterized by irreversible lung damage resulting in airflow limitation, abnormal…”
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Single nucleotide polymorphisms 5′ upstream the coding region of the NEIL2 gene influence gene transcription levels and alter levels of genetic damage by Kinslow, Carla J., El-Zein, Randa A., Hill, Courtney E., Wickliffe, Jeffrey K., Abdel-Rahman, Sherif Z.

“…NEIL2 (EC 4.2.99.18), a mammalian DNA glycosylase and ortholog of the bacterial Fpg/Nei, excises oxidized DNA lesions from bubble or single‐stranded…”
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Detection of human cytomegalovirus in different histological types of gliomas by Scheurer, Michael E., Bondy, Melissa L., Aldape, Kenneth D., Albrecht, Thomas, El-Zein, Randa

“…The association between human cytomegalovirus (HCMV) infection and glioblastoma has been a source of debate in recent years because of conflicting laboratory…”
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