Search Results - "El‐Saghier, Ahmed M."

Synthesis and antidiabetic activity of novel triazole derivatives containing amino acids by Mohamed, Mounir A. A., Abd Allah, Omyma A., Bekhit, Adnan A., Kadry, Asmaa M., El‐Saghier, Ahmed M. M.

“…New series of triazole derivatives coupled with amino acids 1a‐h were obtained via multicomponent reaction of 2‐hydroxy benzaldehyde or 2‐hydroxy acetophenone…”
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Green synthesis, biological and molecular docking of some novel sulfonamide thiadiazole derivatives as potential insecticidal against Spodoptera littoralis by El-Saghier, Ahmed M., Enaili, Souhaila S., Kadry, Asmaa M., Abdou, Aly, Gad, Mohamed A.

“…Although crop plants provide the majority of human food, pests and insects frequently cause huge economic losses. In order to develop innovative insecticidal…”
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An operationally simple, one‐pot, convenient synthesis, and in vitro anti‐inflammatory activity of some new spirotriazolotriazine derivatives by El‐Saghier, Ahmed M., Enaili, Souhaila S., Abdou, Aly, Hamed, Amany M., Kadry, Asmaa M.

“…The wide biological actions of triazolotriazine hybrids, benzene‐sulfonamide derivatives, exhibit a good chance of displaying in vitro anti‐inflammatory…”
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Synthesis and insecticide evaluation of some new oxopropylthiourea compounds as insect growth regulators against the cotton leafworm, Spodoptera littoralis by El-Saghier, Ahmed M., Abosella, Laila, Aborahma, Gamal A., Elakesh, Esmail O., Abdelhamid, Antar A., Gad, Mohamed A.

“…In this project we aim to share in increasing the production of the most important non-food agricultural product i.e. cotton via protection of it is plant. The…”
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Design, synthesis and mechanistic study of N-4-Piperazinyl Butyryl Thiazolidinedione derivatives of ciprofloxacin with Anticancer Activity via Topoisomerase I/II inhibition by Aziz, Hossameldin A., El-Saghier, Ahmed M., badr, Mohamed, Elsadek, Bakheet E. M., Abuo-Rahma, Gamal El-Din A., Shoman, Mai E.

“…A new group of thiazolidine-2,4-dione derivatives of ciprofloxacin having butyryl linker 3a-l was synthesized via an alkylation of thiazolidine-2,4-diones with…”
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Thiazolidine-2,4-dione-linked ciprofloxacin derivatives with broad-spectrum antibacterial, MRSA and topoisomerase inhibitory activities by Aziz, Hossameldin A., El-Saghier, Ahmed M. M., Badr, Mohamed, Abuo-Rahma, Gamal El-Din A., Shoman, Mai E.

“…A series of ciprofloxacin/thiazolidine-2,4-dione hybrids 3a-m were prepared and identified by IR, 1 HNMR, 13 CNMR and elemental analysis. The antibacterial…”
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Multi‐component Reactions, Solvent‐free Synthesis of Substituted Pyrano‐pyridopyrimidine under Different Conditions Using ZnO Nanoparticles by Mahmoud, Naglaa F. H., El‐Saghier, Ahmed M.

“…2‐Amino‐4‐(4‐substitutedphenyl)‐5‐oxo‐4H,5H‐pyrano[2,3‐d]pyrido[1,2‐a]pyrimidine‐3‐carbonitrile‐derivatives 2–12 were synthesized via multi‐component…”
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Ultrasound-assisted green synthesis of triazole-based azomethine/thiazolidin-4-one hybrid inhibitors for cancer therapy through targeting dysregulation signatures of some Rab proteins by Abdelmonsef, Aboubakr H., El-Saghier, Ahmed M., Kadry, Asmaa M.

“…The overexpression of Rab proteins was linked to cancer development, making this family of proteins an attractive drug target for the identification of novel…”
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Synthesis, DFT Calculations, Antiproliferative, Bactericidal Activity and Molecular Docking of Novel Mixed-Ligand Salen/8-Hydroxyquinoline Metal Complexes by Al-Farhan, Badriah Saad, Basha, Maram T., Abdel Rahman, Laila H., El-Saghier, Ahmed M. M., Abou El-Ezz, Doaa, Marzouk, Adel A., Shehata, Mohamed R., Abdalla, Ehab M.

“…Despite the common use of salens and hydroxyquinolines as therapeutic and bioactive agents, their metal complexes are still under development. Here, we report…”
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Synthesis and antimicrobial activity of some novel 1,2-dihydro-[1,2,4]triazolo[1,5-]pyrimidines bearing amino acid moiety by Mohamed, Mounir A. A, Bekhit, Adnan A, Abd Allah, Omyma A, Kadry, Asmaa M, Ibrahim, Tamer M, Bekhit, Salma A, Amagase, Kikuko, El-Saghier, Ahmed M. M

“…A new series of [1,2,4]-triazole bearing amino acid derivatives 2a-d - 9a-d were synthesized under green chemistry conditions via multicomponent reaction using…”
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Eco-Friendly Synthesis, Biological Evaluation, and In Silico Molecular Docking Approach of Some New Quinoline Derivatives as Potential Antioxidant and Antibacterial Agents by El-Saghier, Ahmed M., El-Naggar, Mohamed, Hussein, Abdel Haleem M., El-Adasy, Abu-Bakr A., Olish, M., Abdelmonsef, Aboubakr H.

“…A new series of quinoline derivatives 5–12 were efficiently synthesized via one-pot multicomponent reaction (MCR) of resorcinol, aromatic aldehydes,…”
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Spiro heterocycles bearing piperidine moiety as potential scaffold for antileishmanial activity: synthesis, biological evaluation, and in silico studies by Mohamed, Mounir A. A., Kadry, Asmaa M., Bekhit, Salma A., Abourehab, Mohammed A. S., Amagase, Kikuko, Ibrahim, Tamer M., El-Saghier, Ahmed M. M., Bekhit, Adnan A.

“…New spiro-piperidine derivatives were synthesised via the eco-friendly ionic liquids in a one-pot fashion. The in vitro antileishmanial activity against…”
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Synthesis, docking and characterization of some novel 5-(S-alkyl)-1.3.4-thiadiazole-2-carboxamide derivatives as anti-inflammatory and antibacterial agents by El-Saghier, Ahmed M., Abdul-Baset, Asmaa, El-Hady, Omer M., El-Raheem, Walaa M. Abd, Kadry, Asmaa M.

“…Because of the great pharmacological and industrial significance of 1,3,4-thiadiazole and its related compounds, researchers are still very interested in them…”
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Synthesis, docking and biological evaluation of purine-5- N -isosteresas anti-inflammatory agents by El-Saghier, Ahmed M, Enaili, Souhaila S, Abdou, Aly, Hamed, Amany M, Kadry, Asmaa M

“…An operationally simple one-pot three-component and convenient synthesis method for a series of diverse purine analogues of 5-amino-7-(substituted)-…”
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Correction: Synthesis, docking and biological evaluation of purine-5- N -isosteres as anti-inflammatory agents by El-Saghier, Ahmed M, Enaili, Souhaila S, Abdou, Aly, Hamed, Amany M, Kadry, Asmaa M

“…[This corrects the article DOI: 10.1039/D4RA02970D.]…”
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An efficient eco-friendly, simple, and green synthesis of some new spiro-N-(4-sulfamoyl-phenyl)-1,3,4-thiadiazole-2-carboxamide derivatives as potential inhibitors of SARS-CoV-2 proteases: drug-likeness, pharmacophore, molecular docking, and DFT exploration by El-Saghier, Ahmed M., Enaili, Souhaila S., Abdou, Aly, Kadry, Asmaa M.

“…Introduction The coronavirus disease 2019 (COVID-19) pandemic has caused a global health crisis. The severe acute respiratory syndrome coronavirus 2…”
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Synthesis and Antibacterial Activity of Certain Fused Azoles and Oxazinones by El-Saghier, Ahmed M., Alwedi, Embarak F., Fawzy, Naglaa M.

“…2‐Phenyl‐4‐benzylidene‐5(4H)‐oxazolones (1a‐e) were used as versatile starting materials for the synthesis of fused compounds such as: 4H‐3,1‐benoxazin‐4‐ones…”
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Thiadiazole/Thiadiazine Derivatives as Insecticidal Agent: Design, Synthesis, and Biological Assessment of 1,3,4-(Thiadiazine/Thiadiazole)-Benzenesulfonamide Derivatives as IGRs Analogues against Spodoptera littoralis by El-Saghier, Ahmed M., Enaili, Souhaila S., Abdou, Aly, Alzahrani, Abdullah Y. A., Ben Moussa, Sana, Gad, Mohamed A., Kadry, Asmaa M.

“…In keeping with our investigation, a simple and practical synthesis of novel heterocyclic compounds with a sulfamoyl moiety that can be employed as…”
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Novel 2‑Acetamido-2-ylidene-4-imidazole Derivatives (El-Saghier Reaction): Green Synthesis, Biological Assessment, and Molecular Docking by El-Saghier, Ahmed M., Abdou, Aly, Mohamed, Mounir A. A., Abd El-Lateef, Hany M., Kadry, Asmaa M.

“…El-Saghier reaction is the novel, general, and green reaction of various amines with ethyl cyanoacetate and ethyl glycinate hydrochloride. A new series of…”
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Synthesis, characterization, in silico molecular docking, and antibacterial activities of some new nitrogen-heterocyclic analogues based on a p -phenolic unit by Hussein, Abdel Haleem M, El-Adasy, Abu-Bakr A, El-Saghier, Ahmed M, Olish, M, Abdelmonsef, Aboubakr H

“…Nitrogen-containing heterocycles have shown pharmacological properties against various diseases. Herein, in our study, flavoHB enzyme is a highly promising…”
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