Search Results - "El‐Rifai, Wa'el"

Clinical management of gastrointestinal stromal tumors: Before and after STI-571 by Dematteo, Ronald P., Heinrich, Michael C., El-Rifai, Wa'el M., Demetri, George

“…Gastrointestinal stromal tumor (GIST) is the most common mesenchymal neoplasm of the gastrointestinal tract. Until recently, surgery has been the only…”
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Expression profiling of gastric adenocarcinoma using cDNA array by El‐Rifai, Wa'el, Frierson, Henry F., Harper, Jeffrey C., Powell, Steven M., Knuutila, Sakari

“…To investigate the expression profile of gastric adenocarcinoma, cDNA array experiments were performed using Atlas Human Cancer 1.2 K Array (Clontech…”
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Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells by Palrasu, Manikandan, Zaika, Elena, El-Rifai, Wael, Garcia-Buitrago, Monica, Piazuelo, Maria Blanca, Wilson, Keith T, Peek, Jr, Richard M, Zaika, Alexander I

“…Approximately half of the world's population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for…”
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TFF1 antagonizes TIMP‐1 mediated proliferative functions in gastric cancer by Omar, Omar M., Soutto, Mohammed, Bhat, Nadeem S., Bhat, Ajaz A., Lu, Heng, Chen, Zheng, El‐Rifai, Wael

“…Tissue inhibitor matrix metalloproteinase‐1 (TIMP1) is one of four identified members of the TIMP family. We evaluated the role of TIMP1 in gastric cancer…”
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Cisplatin‐resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib by Wang, Lihong, Arras, Janet, Katsha, Ahmed, Hamdan, Saif, Belkhiri, Abbes, Ecsedy, Jeffrey, El‐Rifai, Wael

“…De novo and acquired resistance to platinum therapy such as cisplatin (CDDP) is a clinical challenge in gastric cancer treatment. Aberrant expression and…”
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Regulation of p53 Tumor Suppressor by Helicobacter pylori in Gastric Epithelial Cells by Wei, Jinxiong, Nagy, Toni A, Vilgelm, Anna, Zaika, Elena, Ogden, Seth R, Romero–Gallo, Judith, Piazuelo, Maria B, Correa, Pelayo, Washington, Mary K, El–Rifai, Wael, Peek, Richard M, Zaika, Alexander

“…Background & Aims Infection with the gastric mucosal pathogen Helicobacter pylori is the strongest identified risk factor for distal gastric cancer. These…”
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Trefoil factor 1 expression suppresses Helicobacter pylori–induced inflammation in gastric carcinogenesis by Soutto, Mohammed, Chen, Zheng, Katsha, Ahmed M., Romero‐Gallo, Judith, Krishna, Uma S., Piazuelo, M. Blanca, Washington, M. Kay, Peek, Richard M., Belkhiri, Abbes, El‐Rifai, Wael M.

“…BACKGROUND Infection with Helicobacter pylori, a high‐risk factor for gastric cancer, is frequently associated with chronic inflammation through activation of…”
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Decreased abundance of trefoil factor 1 transcript in the majority of gastric carcinomas by Beckler, Andrew D., Roche, James K., Harper, Jeffrey C., Petroni, Gina, Frierson, Henry F., Moskaluk, Christopher A., El‐Rifai, Wa'el, Powell, Steven M.

“…BACKGROUND Gastric carcinoma is one of the leading causes of cancer‐related death worldwide, but the mechanisms underlying its development and progression…”
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High-resolution deletion mapping of chromosome 14 in stromal tumors of the gastrointestinal tract suggests two distinct tumor suppressor loci by El-Rifai, Wa'el, Sarlomo-Rikala, Maarit, Andersson, Leif C., Miettinen, Markku, Knuutila, Sakari

“…DNA copy number losses at chromosome arm 14q are the most frequently occurring aberrations in gastrointestinal stromal tumors (GISTs). To characterize the…”
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Evaluation of malignancy and prognosis of gastrointestinal stromal tumors: A review by Miettinen, Markku, El-Rifai, Wa'El, H, Leslie, Lasota, Jerzy

“…This paper reviews data on the prognosis of gastrointestinal stromal tumors (GISTs). These tumors are specific KIT-expressing and KIT-signaling–driven…”
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Genetic differences between adenocarcinomas arising in Barrett's esophagus and gastric mucosa by El–Rifai, Wa'el, Frierson, Henry F., Moskaluk, Christopher A., Harper, Jeffrey C., Petroni, Gina R., Bissonette, Eric A., Jones, David R., Knuutila, Sakari, Powell, Steven M.

“…Background & Aims: Barrett adenocarcinoma (BA+) and gastric adenocarcinoma comprise a related group of neoplasms that nevertheless have some distinct…”
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Promoter DNA hypermethylation in gastric biopsies from subjects at high and low risk for gastric cancer by Schneider, Barbara G., Peng, Dun‐Fa, Camargo, M. Constanza, Piazuelo, M. Blanca, Sicinschi, Liviu A., Mera, Robertino, Romero‐Gallo, Judith, Delgado, Alberto G., Bravo, Luis E., Wilson, Keith T., Peek, Richard M., Correa, Pelayo, El‐Rifai, Wael

“…Gene promoter CpG island hypermethylation is associated with Helicobacter pylori (H. pylori) infection and may be an important initiator of gastric…”
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Expression of Tight-Junction Protein Claudin-7 Is an Early Event in Gastric Tumorigenesis by Johnson, Adam H., Frierson, Henry F., Zaika, Alexander, Powell, Steven M., Roche, James, Crowe, Sheila, Moskaluk, Christopher A., El-Rifai, Wa'el

“…Trefoil factor-1 (Tff1) expression is remarkably down-regulated in nearly all human gastric cancers. Therefore, we used the Tff1 knockout mouse model to detect…”
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Hypermethylation, Loss of Expression of Glutathione Peroxidase-3 in Barrett's Tumorigenesis by Lee, Ok-Jae, Schneider-Stock, Regine, McChesney, Patricia A., Kuester, Doerthe, Roessner, Albert, Vieth, Michael, Moskaluk, Christopher A., El-Rifai, Wa'el

“…Chronic gastroesophageal reflux disease is a known risk factor for Barrett's esophagus (BE), that induces oxidative mucosal damage. Glutathione peroxidase-3…”
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Overexpression, genomic amplification and therapeutic potential of inhibiting the UbcH10 ubiquitin conjugase in human carcinomas of diverse anatomic origin by WAGNER, Klaus W, SAPINOSO, Lisa M, EL-RIFAI, Wa'El, FRIERSON, Henry F, BUTZ, Nicole, MESTAN, Juergen, HOFMANN, Francesco, DEVERAUX, Quinn L, HAMPTON, Garret M

“…Gene expression profiling of anatomically diverse carcinomas and their corresponding normal tissues was used to identify genes with cancer-associated…”
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Targets of gene amplification and overexpression at 17q in gastric cancer by VARIS, Asta, WOLF, Maija, EL-RIFAI, Wa'El, MONNI, Outi, VAKKARI, Marja-Leena, KOKKOLA, Arto, MOSKALUK, Chris, FRIERSON, Henry JR, POWELL, Steven M, KNUUTILA, Sakari, KALLIONIEMI, Anne

“…DNA copy number gains and amplifications at 17q are frequent in gastriccancer, yet systematic analyses of the 17q amplicon have not been performed. In this…”
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Liquid biopsy: a step closer to transform diagnosis, prognosis and future of cancer treatments by Lone, Saife N, Nisar, Sabah, Masoodi, Tariq, Singh, Mayank, Rizwan, Arshi, Hashem, Sheema, El-Rifai, Wael, Bedognetti, Davide, Batra, Surinder K, Haris, Mohammad, Bhat, Ajaz A, Macha, Muzafar A

“…Over the past decade, invasive techniques for diagnosing and monitoring cancers are slowly being replaced by non-invasive methods such as liquid biopsy. Liquid…”
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DNA Copy Number Losses in Human Neoplasms by Knuutila, Sakari, Aalto, Yan, Autio, Kirsi, Björkqvist, Anna-Maria, El-Rifai, Wa'el, Hemmer, Samuli, Huhta, Tarja, Kettunen, Eeva, Kiuru-Kuhlefelt, Sonja, Larramendy, Marcelo L., Lushnikova, Tamara, Monni, Outi, Pere, Heini, Tapper, Johanna, Tarkkanen, Maija, Varis, Asta, Wasenius, Veli-Matti, Wolf, Maija, Zhu, Ying

“…This review summarizes reports of recurrent DNA sequence copy number losses in human neoplasms detected by comparative genomic hybridization. Recurrent losses…”
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Epigenetic regulation of AURKA by miR-4715-3p in upper gastrointestinal cancers by Gomaa, Ahmed, Peng, Dunfa, Chen, Zheng, Soutto, Mohammed, Abouelezz, Khaled, Corvalan, Alejandro, El-Rifai, Wael

“…Aurora kinase A (AURKA) is frequently overexpressed in several cancers. miRNA sequencing and bioinformatics analysis indicated significant downregulation of…”
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Silencing of MGMT expression by promoter hypermethylation in the metaplasia–dysplasia–carcinoma sequence of Barrett’s esophagus by Kuester, Doerthe, El-Rifai, Wa’el, Peng, DunFa, Ruemmele, Petra, Kroeckel, Ivonne, Peters, Brigitte, Moskaluk, Christopher A, Stolte, Manfred, Mönkemüller, Klaus, Meyer, Frank, Schulz, Hans-Ulrich, Hartmann, Arndt, Roessner, Albert, Schneider-Stock, Regine

“…Abstract To determine the relevance of MGMT in Barrett’s carcinogenesis, we analyzed promotor hypermethylation and expression of MGMT in Barrett’s…”
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