Assessment of seminal plasma laminin in fertile and infertile men

Assessment of seminal plasma laminin in fertile and infertile men

Aim: To assess laminin levels in the seminal plasma of infertile and fertile men, and to analyze the correlation of laminin levels with sperm count, age, sperm motility and semen volume. Methods: One hundred and twenty‐five recruited men were equally divided into five groups according to their sperm...

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Published in:Asian journal of andrology Vol. 9; no. 1; pp. 63 - 67
Main Authors: El‐Dakhly, Mohamed R., Tawadrous, Gamil A., Mostafa, Taymour, Roaia, Mohamed M. F., El‐Nashar, Abdel R. M., Shedeed, Shedeed A., Kamel, Ihab I., Aziz, Amal A., El‐Mohtaseb, Yasser
Format: Journal Article
Language:English
Published: Melbourne, Australia Blackwell Publishing Asia 01-01-2007
Medknow Publications & Media Pvt. Ltd
Subjects:
Adult
azoospermia
Azoospermia - physiopathology
basement membrane
congenital bilateral absent vas deferens
Fertility - physiology
Humans
Infertility, Male - physiopathology
laminin
Laminin - metabolism
Male
male infertility
Oligospermia - physiopathology
semen
Semen - physiology
seminal plasma
Sperm Count
Sperm Motility
testis
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Summary:Aim: To assess laminin levels in the seminal plasma of infertile and fertile men, and to analyze the correlation of laminin levels with sperm count, age, sperm motility and semen volume. Methods: One hundred and twenty‐five recruited men were equally divided into five groups according to their sperm concentration and clinical examination: fertile normozoospermia, oligoasthenozoospermia, non‐obstructive azoospermia (NOA), obstructive azoospermia (OA) and congenital bilateral absent vas deferens (CBAVD). The patients' medical history was investigated and patients underwent clinical examination, conventional semen analysis and estimation of seminal plasma laminin by radioimmunoassay. Results: Seminal plasma laminin levels of successive groups were: 2.82 ± 0.62, 2.49 ± 0.44, 1.77 ± 0.56, 1.72 ± 0.76, 1.35 ± 0.63 U/mL, respectively. The fertile normozoospermic group showed the highest concentration compared to all infertile groups with significant differences compared to azoospermic groups (P < 0.05). Testicular contribution was estimated to be approximately one‐third of the seminal laminin. Seminal plasma laminin demonstrated significant correlation with sperm concentration (r= 0.460, P < 0.001) and nonsignificant correlation with age (r= 0.021, P= 0.940), sperm motility percentage (r= 0.142, P= 0.615) and semen volume (r= 0.035, P= 0.087). Conclusion: Seminal plasma laminin is derived mostly from prostatic and testicular portions and minimally from the seminal vesicle and vas deferens. Estimating seminal laminin alone is not conclusive in diagnosing different cases of male infertility. Edited by Aleksander Giwercman
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ISSN:1008-682X
1745-7262
DOI:10.1111/j.1745-7262.2007.00234.x