Search Results - "Ekstrom, Thomas L"

Robust activation of microhomology-mediated end joining for precision gene editing applications by Ata, Hirotaka, Ekstrom, Thomas L, Martínez-Gálvez, Gabriel, Mann, Carla M, Dvornikov, Alexey V, Schaefbauer, Kyle J, Ma, Alvin C, Dobbs, Drena, Clark, Karl J, Ekker, Stephen C

“…One key problem in precision genome editing is the unpredictable plurality of sequence outcomes at the site of targeted DNA double stranded breaks (DSBs). This…”
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VLX600 Disrupts Homologous Recombination and Synergizes with PARP Inhibitors and Cisplatin by Inhibiting Histone Lysine Demethylases by Ekstrom, Thomas L, Pathoulas, Nicholas M, Huehls, Amelia M, Kanakkanthara, Arun, Karnitz, Larry M

“…Tumors with defective homologous recombination (HR) DNA repair are more sensitive to chemotherapies that induce lesions repaired by HR as well as PARP…”
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BRCA1 Deficiency Upregulates NNMT, Which Reprograms Metabolism and Sensitizes Ovarian Cancer Cells to Mitochondrial Metabolic Targeting Agents by Kanakkanthara, Arun, Kurmi, Kiran, Ekstrom, Thomas L, Hou, Xiaonan, Purfeerst, Emma R, Heinzen, Ethan P, Correia, Cristina, Huntoon, Catherine J, O'Brien, Daniel, Wahner Hendrickson, Andrea E, Dowdy, Sean C, Li, Hu, Oberg, Ann L, Hitosugi, Taro, Kaufmann, Scott H, Weroha, S John, Karnitz, Larry M

“…BRCA1 plays a key role in homologous recombination (HR) DNA repair. Accordingly, changes that downregulate BRCA1, including mutations and reduced…”
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Repurposing Ceritinib Induces DNA Damage and Enhances PARP Inhibitor Responses in High-Grade Serous Ovarian Carcinoma by Kanakkanthara, Arun, Hou, Xiaonan, Ekstrom, Thomas L, Zanfagnin, Valentina, Huehls, Amelia M, Kelly, Rebecca L, Ding, Husheng, Larson, Melissa C, Vasmatzis, George, Oberg, Ann L, Kaufmann, Scott H, Mansfield, Aaron S, Weroha, S John, Karnitz, Larry M

“…PARP inhibitors (PARPi) have activity in homologous recombination (HR) repair-deficient, high-grade serous ovarian cancers (HGSOC). However, even responsive…”
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Interactive enhancer hubs (iHUBs) mediate transcriptional reprogramming and adaptive resistance in pancreatic cancer by Hamdan, Feda H, Abdelrahman, Amro M, Kutschat, Ana Patricia, Wang, Xin, Ekstrom, Thomas L, Jalan-Sakrikar, Nidhi, Wegner Wippel, Catherine, Taheri, Negar, Tamon, Liezel, Kopp, Waltraut, Aggrey-Fynn, Joana, Bhagwate, Aditya V, Alva-Ruiz, Roberto, Lynch, Isaac, Yonkus, Jennifer, Kosinsky, Robyn Laura, Gaedcke, Jochen, Hahn, Stephan A, Siveke, Jens T, Graham, Rondell, Najafova, Zeynab, Hessmann, Elisabeth, Truty, Mark J, Johnsen, Steven A

“…Pancreatic ductal adenocarcinoma (PDAC) displays a remarkable propensity towards therapy resistance. However, molecular epigenetic and transcriptional…”
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Addressing Enzyme‐Substrate Interaction Misconceptions with 3D Physical Models in an Undergraduate Biochemistry Course by Ekstrom, Thomas L., Terrell, Cassidy R.

“…Biochemistry is a visual discipline that requires students to understand a variety of representations containing diverse levels of ion to portray information…”
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Abstract 1481: MAPK and NF-kappaB signaling converge on the epigenome to transcriptionally activate genes involved in pancreatic cancer metastasis by Aggrey-Fynn, Joana E., Hamdan, Feda H., Wixom, Alexander Q., Ekstrom, Thomas L., Johnsen, Steven A.

“…Abstract Pancreatic ductal adenocarcinoma (PDAC) is the most prevalent and highly aggressive type of pancreatic neoplasm. Unfortunately, most patients will…”
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