Search Results - "Eksioglu, Erika A."

TP53 mutations in myelodysplastic syndromes and secondary AML confer an immunosuppressive phenotype by Sallman, David A., McLemore, Amy F., Aldrich, Amy L., Komrokji, Rami S., McGraw, Kathy L., Dhawan, Abhishek, Geyer, Susan, Hou, Hsin-An, Eksioglu, Erika A., Sullivan, Amy, Warren, Sarah, MacBeth, Kyle J., Meggendorfer, Manja, Haferlach, Torsten, Boettcher, Steffen, Ebert, Benjamin L., Al Ali, Najla H., Lancet, Jeffrey E., Cleveland, John L., Padron, Eric, List, Alan F.

“…Somatic gene mutations are key determinants of outcome in patients with myelodysplastic syndromes (MDS) and secondary AML (sAML). In particular, patients with…”
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The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype by Basiorka, Ashley A., McGraw, Kathy L., Eksioglu, Erika A., Chen, Xianghong, Johnson, Joseph, Zhang, Ling, Zhang, Qing, Irvine, Brittany A., Cluzeau, Thomas, Sallman, David A., Padron, Eric, Komrokji, Rami, Sokol, Lubomir, Coll, Rebecca C., Robertson, Avril A.B., Cooper, Matthew A., Cleveland, John L., O'Neill, Luke A., Wei, Sheng, List, Alan F.

“…Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a…”
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Induction of myelodysplasia by myeloid-derived suppressor cells by Chen, Xianghong, Eksioglu, Erika A, Zhou, Junmin, Zhang, Ling, Djeu, Julie, Fortenbery, Nicole, Epling-Burnette, Pearlie, Van Bijnen, Sandra, Dolstra, Harry, Cannon, John, Youn, Je-in, Donatelli, Sarah S, Qin, Dahui, De Witte, Theo, Tao, Jianguo, Wang, Huaquan, Cheng, Pingyan, Gabrilovich, Dmitry I, List, Alan, Wei, Sheng

“…Myelodysplastic syndromes (MDS) are age-dependent stem cell malignancies that share biological features of activated adaptive immune response and ineffective…”
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TGF-β—inducible microRNA-183 silences tumor-associated natural killer cells by Donatelli, Sarah S., Zhou, Jun-Min, Gilvary, Danielle L., Eksioglu, Erika A., Chen, Xianghong, Cress, W. Douglas, Haura, Eric B., Schabath, Matthew B., Coppola, Domenico, Wei, Sheng, Djeu, Julie Y.

“…Transforming growth factor β1 (TGF-β), enriched in the tumor microenvironment and broadly immunosuppressive, inhibits natural killer (NK) cell function by…”
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Inactivation of DAP12 in PMN inhibits TREM1-mediated activation in rheumatoid arthritis by Chen, Xianghong, Eksioglu, Erika A, Carter, John D, Fortenbery, Nicole, Donatelli, Sarah S, Zhou, Junmin, Liu, Jinhong, Yang, Lili, Gilvary, Danielle, Djeu, Julie, Wei, Sheng

“…Rheumatoid arthritis (RA) is an autoimmune disease characterized by dysregulated and chronic systemic inflammatory responses that affect the synovium, bone,…”
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Oxidized Mitochondrial DNA Engages TLR9 to Activate the NLRP3 Inflammasome in Myelodysplastic Syndromes by Ward, Grace A, Dalton, 3rd, Robert P, Meyer, Benjamin S, McLemore, Amy F, Aldrich, Amy L, Lam, Nghi B, Onimus, Alexis H, Vincelette, Nicole D, Trinh, Thu Le, Chen, Xianghong, Calescibetta, Alexandra R, Christiansen, Sean M, Hou, Hsin-An, Johnson, Joseph O, Wright, Kenneth L, Padron, Eric, Eksioglu, Erika A, List, Alan F

“…Myelodysplastic Syndromes (MDSs) are bone marrow (BM) failure malignancies characterized by constitutive innate immune activation, including NLRP3 inflammasome…”
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HMGB1 induction of clusterin creates a chemoresistant niche in human prostate tumor cells by Zhou, Junmin, Chen, Xianghong, Gilvary, Danielle L., Tejera, Melba M., Eksioglu, Erika A., Wei, Sheng, Djeu, Julie Y.

“…Development of chemoresistance, especially to docetaxel (DTX), is the primary barrier to the cure of castration-resistant prostate cancer but its mechanism is…”
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Constitutively Activated DAP12 Induces Functional Anti-Tumor Activation and Maturation of Human Monocyte-Derived DC by Dalton, Robert, Calescibetta, Alexandra, Zhou, Jun Min, Maurin, Michelle, Ward, Grace, Trinh, Thu Le, Tu, Nhan, Gilvary, Danielle, Chen, Xianghong, Cheng, Pingyan, Kostenko, Elena, Wei, Sheng, Wright, Kenneth L, Eksioglu, Erika A

“…Dendritic cells (DCs) are professional antigen presenting cells with a great capacity for cross-presentation of exogenous antigens from which robust anti-tumor…”
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MicroRNA-155 governs SHIP-1 expression and localization in NK cells and regulates subsequent infiltration into murine AT3 mammary carcinoma by Kandell, Wendy M, Donatelli, Sarah S, Trinh, Thu Le, Calescibetta, Alexandra R, So, Tina, Tu, Nhan, Gilvary, Danielle L, Chen, Xianghong, Cheng, Pingyan, Adams, William A, Chen, Yin-Kai, Liu, Jinhong, Djeu, Julie Y, Wei, Sheng, Eksioglu, Erika A

“…NK cell migration and activation are crucial elements of tumor immune surveillance. In mammary carcinomas, the number and function of NK cells is diminished,…”
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Immune evasion by TGFβ-induced miR-183 repression of MICA/B expression in human lung tumor cells by Trinh, Thu Le, Kandell, Wendy M., Donatelli, Sarah S., Tu, Nhan, Tejera, Melba M., Gilvary, Danielle L., Eksioglu, Erika A., Burnette, Alexis, Adams, William A., Liu, Jinhong, Teer, Jamie K., Djeu, Julie Y., Coppola, Domenico, Wei, Sheng

“…Immune escape is a hallmark of cancer. In human lung cancer, we have identified a unique microRNA (miR)-based pathway employed by tumor cells to repress…”
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Dendritic cells as therapeutic agents against cancer by Eksioglu, Erika A, Eisen, Sarah, Reddy, Vijay

“…Dendritic cells (DC) are antigen-presenting cells whose immunobiology has been proven to be central to the function of the immune system. Further understanding…”
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CX3CR1 deficiency-induced TIL tumor restriction as a novel addition for CAR-T design in solid malignancies by Trinh, ThuLe, Adams, William A., Calescibetta, Alexandra, Tu, Nhan, Dalton, Robert, So, Tina, Wei, Max, Ward, Grace, Kostenko, Elena, Christiansen, Sean, Cen, Ling, McLemore, Amy, Reed, Kayla, Whitting, Junmin, Gilvary, Danielle, Blanco, Neale Lopez, Segura, Carlos Moran, Nguyen, Jonathan, Kandell, Wendy, Chen, Xianghong, Cheng, Pingyan, Wright, Gabriela M., Cress, W. Douglas, Liu, Jinghong, Wright, Kenneth L., Wei, Sheng, Eksioglu, Erika A.

“…Advances in the understanding of the tumor microenvironment have led to development of immunotherapeutic strategies, such as chimeric antigen receptor T cells…”
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Characterization of HCV interactions with Toll-like receptors and RIG-I in liver cells by Eksioglu, Erika A, Zhu, Haizhen, Bayouth, Lilly, Bess, Jennifer, Liu, Hong-Yan, Nelson, David R, Liu, Chen

“…The aim of this study was to examine the mechanisms of IFN induction and viral escape. In order to accomplish the goal we compared our new hepatoma cell line…”
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Bone marrow mononuclear cells up-regulate toll-like receptor expression and produce inflammatory mediators in response to cigarette smoke extract by Zhou, Junmin, Eksioglu, Erika A, Fortenbery, Nicole R, Chen, Xianghong, Wang, Huaquan, Epling-Burnette, Pearlie K, Djeu, Julie Y, Wei, Sheng

“…Several reports link cigarette smoking with leukemia. However, the effects of cigarette smoke extract (CSE) on bone marrow hematopoiesis remain unknown. The…”
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S100A9-induced overexpression of PD-1/PD-L1 contributes to ineffective hematopoiesis in myelodysplastic syndromes by Cheng, Pinyang, Eksioglu, Erika A., Chen, Xianghong, Kandell, Wendy, Le Trinh, Thu, Cen, Ling, Qi, Jin, Sallman, David A., Zhang, Yu, Tu, Nhan, Adams, William A., Zhang, Chunze, Liu, Jinhong, Cleveland, John L., List, Alan F., Wei, Sheng

“…Myelodysplastic syndromes (MDS) are characterized by dysplastic and ineffective hematopoiesis that can result from aberrant expansion and activation of…”
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Immunodepletion of MDSC by AMV564, a novel bivalent, bispecific CD33/CD3 T cell engager, ex vivo in MDS and melanoma by Cheng, Pingyan, Chen, Xianghong, Dalton, Robert, Calescibetta, Alexandra, So, Tina, Gilvary, Danielle, Ward, Grace, Smith, Victoria, Eckard, Sterling, Fox, Judith A., Guenot, Jeanmarie, Markowitz, Joseph, Cleveland, John L., Wright, Kenneth L., List, Alan F., Wei, Sheng, Eksioglu, Erika A.

“…We have reported previously that CD33hi myeloid-derived suppressor cells (MDSCs) play a direct role in the pathogenesis of myelodysplastic syndromes (MDSs) and…”
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Grassystatins A−C from Marine Cyanobacteria, Potent Cathepsin E Inhibitors That Reduce Antigen Presentation by Kwan, Jason C., Eksioglu, Erika A., Liu, Chen, Paul, Valerie J., Luesch, Hendrik

“…In our efforts to explore marine cyanobacteria as a source of novel bioactive compounds, we discovered a statine unit-containing linear decadepsipeptide,…”
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Therapeutic targeting of myeloid-derived suppressor cells involves a novel mechanism mediated by clusterin by Zhou, Junmin, Donatelli, Sarah S., Gilvary, Danielle L., Tejera, Melba M., Eksioglu, Erika A., Chen, Xianghong, Coppola, Domenico, Wei, Sheng, Djeu, Julie Y.

“…Myeloid-derived suppressor cells (MDSCs) constitute a key checkpoint that impedes tumor immunity against cancer. Chemotherapeutic intervention of MDSCs has…”
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Assessment of ASC specks as a putative biomarker of pyroptosis in myelodysplastic syndromes: an observational cohort study by Basiorka, Ashley A, McGraw, Kathy L, Abbas-Aghababazadeh, Farnoosh, McLemore, Amy F, Vincelette, Nicole D, Ward, Grace A, Eksioglu, Erika A, Sallman, David A, Ali, Najla Al, Padron, Eric, Pinilla-Ibarz, Javier, Komrokji, Rami, Masala, Erico, Santini, Valeria, Kosmider, Olivier, Fontenay, Michaela, Fenaux, Pierre, Sokol, Lubomir, Wei, Sheng, Fridley, Brooke, List, Alan F

“…NLRP3 inflammasome-directed pyroptotic cell death drives ineffective haemopoiesis in myelodysplastic syndromes. During inflammasome assembly, the…”
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Icariside II Induces Apoptosis of Melanoma Cells Through the Downregulation of Survival Pathways by Wu, Jinfeng, Xu, Jinhua, Eksioglu, Erika A, Chen, Xianghong, Zhou, Junmin, Fortenbery, Nicole, Wei, Sheng, Dong, Jingcheng

“…This study evaluated the antitumor effects of icariside II (IS), isolated from Herba Epimedii, on in vitro and in vivo models of melanoma and determined its…”
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