Search Results - "Ekman, Drew R"

Use cases, best practice and reporting standards for metabolomics in regulatory toxicology by Viant, Mark R., Ebbels, Timothy M. D., Beger, Richard D., Ekman, Drew R., Epps, David J. T., Kamp, Hennicke, Leonards, Pim E. G., Loizou, George D., MacRae, James I., van Ravenzwaay, Bennard, Rocca-Serra, Philippe, Salek, Reza M., Walk, Tilmann, Weber, Ralf J. M.

“…Metabolomics is a widely used technology in academic research, yet its application to regulatory science has been limited. The most commonly cited barrier to…”
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Endocrine disrupting chemicals in fish: Developing exposure indicators and predictive models of effects based on mechanism of action by Ankley, Gerald T., Bencic, David C., Breen, Michael S., Collette, Timothy W., Conolly, Rory B., Denslow, Nancy D., Edwards, Stephen W., Ekman, Drew R., Garcia-Reyero, Natalia, Jensen, Kathleen M., Lazorchak, James M., Martinović, Dalma, Miller, David H., Perkins, Edward J., Orlando, Edward F., Villeneuve, Daniel L., Wang, Rong-Lin, Watanabe, Karen H.

“…Knowledge of possible toxic mechanisms (or modes) of action (MOA) of chemicals can provide valuable insights as to appropriate methods for assessing exposure…”
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International NMR-Based Environmental Metabolomics Intercomparison Exercise by Viant, Mark R, Bearden, Daniel W, Bundy, Jacob G, Burton, Ian W, Collette, Timothy W, Ekman, Drew R, Ezernieks, Vilnis, Karakach, Tobias K, Lin, Ching Yu, Rochfort, Simone, Ropp, Jeffrey S. de, Teng, Quincy, Tjeerdema, Ronald S, Walter, John A, Wu, Huifeng

“…Several fundamental requirements must be met so that NMR-based metabolomics and the related technique of metabonomics can be formally adopted into…”
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Derivation and Evaluation of Putative Adverse Outcome Pathways for the Effects of Cyclooxygenase Inhibitors on Reproductive Processes in Female Fish by Martinovic-Weigelt, Dalma, Mehinto, Alvine C, Ankley, Gerald T, Berninger, Jason P, Collette, Timothy W, Davis, John M, Denslow, Nancy D, Durhan, Elizabeth J, Eid, Evan, Ekman, Drew R, Jensen, Kathleen M, Kahl, Michael D, LaLone, Carlie A, Teng, Quincy, Villeneuve, Daniel L

“…Cyclooxygenase (COX) inhibitors are ubiquitous in aquatic systems and have been detected in fish tissues. The exposure of fish to these pharmaceuticals is…”
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Fishy aroma of social status: urinary chemo-signalling of territoriality in male fathead minnows (Pimephales promelas) by Martinovic-Weigelt, Dalma, Ekman, Drew R, Villeneuve, Daniel L, James, Channing M, Teng, Quincy, Collette, Timothy W, Ankley, Gerald T

“…Chemical structures of several urinary reproductive pheromones in fish have been identified, and their role in the chemical communication of reproductive…”
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Impacts of an Anti-Androgen and an Androgen/Anti-Androgen Mixture on the Metabolite Profile of Male Fathead Minnow Urine by Collette, Timothy W, Teng, Quincy, Jensen, Kathleen M, Kahl, Michael D, Makynen, Elizabeth A, Durhan, Elizabeth J, Villeneuve, Daniel L, Martinović-Weigelt, Dalma, Ankley, Gerald T, Ekman, Drew R

“…Male and female fathead minnows (Pimephales promelas, FHM) were exposed via water to 20 or 200 μg/L of cyproterone acetate (CA), a model androgen receptor (AR)…”
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SAGE analysis of transcriptome responses in Arabidopsis roots exposed to 2,4,6-trinitrotoluene by Ekman, D.R, Lorenz, W.W, Przybyla, A.E, Wolfe, N.L, Dean, J.F.D

“…Serial analysis of gene expression was used to profile transcript levels in Arabidopsis roots and assess their responses to 2,4,6-trinitrotoluene (TNT)…”
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Integration of metabolomics and in vitro metabolism assays for investigating the stereoselective transformation of triadimefon in rainbow trout by Kenneke, John F., Ekman, Drew R., Mazur, Chris S., Konwick, Brad J., Fisk, Aaron T., Avants, Jimmy K., Garrison, A. Wayne

“…Triadimefon is a systemic agricultural fungicide of the triazole class whose major metabolite, triadimenol, also a commercial fungicide, provides the majority…”
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Assessing the impact of wastewater treatment plant effluent on downstream drinking water-source quality using a zebrafish (Danio Rerio) liver cell-based metabolomics approach by Zhen, Huajun, Ekman, Drew R., Collette, Timothy W., Glassmeyer, Susan T., Mills, Marc A., Furlong, Edward T., Kolpin, Dana W., Teng, Quincy

“…Cell-based metabolomics was used in a proof-of-concept fashion to investigate the biological effects of contaminants as they traveled from a wastewater…”
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Untargeted Lipidomics for Determining Cellular and Subcellular Responses in Zebrafish (Danio rerio) Liver Cells Following Exposure to Complex Mixtures in U.S. Streams by Zhen, Huajun, Teng, Quincy, Mosley, Jonathan D, Collette, Timothy W, Yue, Yang, Bradley, Paul M, Ekman, Drew R

“…Surface waters often contain a variety of chemical contaminants potentially capable of producing adverse outcomes in both humans and wildlife due to impacts…”
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Multi-omic responses of fish exposed to complex chemical mixtures in the Shenandoah River watershed by Bertolatus, David W, Barber, Larry B, Martyniuk, Christopher J, Zhen, Huajun, Collette, Timothy W, Ekman, Drew R, Jastrow, Aaron, Rapp, Jennifer L, Vajda, Alan M

“…To evaluate relationships between different anthropogenic impacts, contaminant occurrence, and fish health, we conducted in situ fish exposures across the…”
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Effects-Based Monitoring of Bioactive Chemicals Discharged to the Colorado River before and after a Municipal Wastewater Treatment Plant Replacement by Cavallin, Jenna E, Battaglin, William A, Beihoffer, Jon, Blackwell, Brett R, Bradley, Paul M, Cole, Alexander R, Ekman, Drew R, Hofer, Rachel N, Kinsey, Julie, Keteles, Kristen, Weissinger, Rebecca, Winkelman, Dana L, Villeneuve, Daniel L

“…Monitoring of the Colorado River near the Moab, Utah, wastewater treatment plant (WWTP) outflow has detected pharmaceuticals, hormones, and estrogen-receptor…”
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direct cell quenching method for cell-culture based metabolomics by Teng, Quincy, Huang, Wenlin, Collette, Timothy W, Ekman, Drew R, Tan, Chalet

“…A crucial step in metabolomic analysis of cellular extracts is the cell quenching process. The conventional method first uses trypsin to detach cells from…”
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Effects-based monitoring of bioactive compounds associated with municipal wastewater treatment plant effluent discharge to the South Platte River, Colorado, USA by Cavallin, Jenna E., Beihoffer, Jon, Blackwell, Brett R., Cole, Alexander R., Ekman, Drew R., Hofer, Rachel, Jastrow, Aaron, Kinsey, Julie, Keteles, Kristen, Maloney, Erin M., Parman, Jordan, Winkelman, Dana L., Villeneuve, Daniel L.

“…Previous studies have detected numerous organic contaminants and in vitro bioactivities in surface water from the South Platte River near Denver, Colorado,…”
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Assessing Contaminants of Emerging Concern in the Great Lakes Ecosystem: A Decade of Method Development and Practical Application by Ankley, Gerald T, Corsi, Steven R, Custer, Christine M, Ekman, Drew R, Hummel, Stephanie L, Kimbrough, Kimani L, Schoenfuss, Heiko L, Villeneuve, Daniel L

“…Assessing the ecological risk of contaminants in the field typically involves consideration of a complex mixture of compounds which may or may not be detected…”
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Expanding non-invasive approaches for fish-health monitoring: A survey of the epidermal mucous metabolomes of phylogenetically diverse freshwater fish species by Ekman, Drew R, Evich, Marina G, Mosley, Jonathan D, Doering, Jon A, Fay, Kellie A, Ankley, Gerald T, Collette, Timothy W

“…There is a pressing need for more-holistic approaches to fisheries assessments along with growing demand to reduce the health impacts of sample collections…”
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Spectral relative standard deviation: a practical benchmark in metabolomics by Parsons, Helen M, Ekman, Drew R, Collette, Timothy W, Viant, Mark R

“…Metabolomics datasets, by definition, comprise of measurements of large numbers of metabolites. Both technical (analytical) and biological factors will induce…”
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Effects of Metformin and its Metabolite Guanylurea on Fathead Minnow (Pimephales promelas) Reproduction by Blackwell, Brett R., Ankley, Gerald T., Biales, Adam D., Cavallin, Jenna E., Cole, Alexander R., Collette, Timothy W., Ekman, Drew R., Hofer, Rachel N., Huang, Weichun, Jensen, Kathleen M., Kahl, Michael D., Kittelson, Ashley R., Romano, Shannon N., See, Mary Jean, Teng, Quincy, Tilton, Charlene B., Villeneuve, Daniel L.

“…Metformin, along with its biotransformation product guanylurea, is commonly observed in municipal wastewaters and subsequent surface waters. Previous studies…”
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Omics for aquatic ecotoxicology: Control of extraneous variability to enhance the analysis of environmental effects by Simmons, Denina B.D., Benskin, Jonathan P., Cosgrove, John R., Duncker, Bernard P., Ekman, Drew R., Martyniuk, Christopher J., Sherry, James P.

“…There are multiple sources of biological and technical variation in a typical ecotoxicology study that may not be revealed by traditional endpoints but that…”
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Evaluation of targeted and untargeted effects-based monitoring tools to assess impacts of contaminants of emerging concern on fish in the South Platte River, CO by Ekman, Drew R., Keteles, Kristen, Beihoffer, Jon, Cavallin, Jenna E., Dahlin, Kenneth, Davis, John M., Jastrow, Aaron, Lazorchak, James M., Mills, Marc A., Murphy, Mark, Nguyen, David, Vajda, Alan M., Villeneuve, Daniel L., Winkelman, Dana L., Collette, Timothy W.

“…Rivers in the arid Western United States face increasing influences from anthropogenic contaminants due to population growth, urbanization, and drought. To…”
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