Search Results - "Ekland, Eric H"

Profiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum by Gulati, Sonia, Ekland, Eric H., Ruggles, Kelly V., Chan, Robin B., Jayabalasingham, Bamini, Zhou, Bowen, Mantel, Pierre-Yves, Lee, Marcus C.S., Spottiswoode, Natasha, Coburn-Flynn, Olivia, Hjelmqvist, Daisy, Worgall, Tilla S., Marti, Matthias, Di Paolo, Gilbert, Fidock, David A.

“…During its life cycle, Plasmodium falciparum undergoes rapid proliferation fueled by de novo synthesis and acquisition of host cell lipids. Consistent…”
Get full text

Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue by Adjalley, Sophie H., Johnston, Geoffrey L., Li, Tao, Eastman, Richard T., Ekland, Eric H., Eappen, Abraham G., Richman, Adam, Sim, B. Kim Lee, Lee, Marcus C. S., Hoffman, Stephen L., Fidock, David A.

“…Clinical studies and mathematical models predict that, to achieve malaria elimination, combination therapies will need to incorporate drugs that block the…”
Get full text

Normalization of the lymph node T cell stromal microenvironment in lpr/lpr mice is associated with SU5416-induced reduction in autoantibodies by Chyou, Susan, Tian, Sha, Ekland, Eric H, Lu, Theresa T

“…The vascular-stromal elements of lymph nodes can play important roles in regulating the activities of the lymphocytes within. During model immune responses,…”
Get full text

Regulation of lymph node vascular growth by dendritic cells by Webster, Brian, Ekland, Eric H, Agle, Lucila M, Chyou, Susan, Ruggieri, Regina, Lu, Theresa T

“…Lymph nodes grow rapidly and robustly at the initiation of an immune response, and this growth is accompanied by growth of the blood vessels. Although the…”
Get full text

Fibroblast-Type Reticular Stromal Cells Regulate the Lymph Node Vasculature by Chyou, Susan, Ekland, Eric H, Carpenter, April C, Tzeng, Te-Chen Jenny, Tian, Sha, Michaud, Michael, Madri, Joseph A, Lu, Theresa T

“…The lymph node vasculature is essential to immune function, but mechanisms regulating lymph node vascular maintenance and growth are not well understood…”
Get full text

Chemokine requirements for B cell entry to lymph nodes and Peyer's patches by Okada, Takaharu, Ngo, Vu N, Ekland, Eric H, Förster, Reinhold, Lipp, Martin, Littman, Dan R, Cyster, Jason G

“…B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we…”
Get full text

Taking Charge: Feeding Malaria via Anion Channels by Ekland, Eric H., Akabas, Myles H., Fidock, David A.

“…The human malaria parasite Plasmodium falciparum increases red blood cell membrane permeability during infection to allow for import of nutrients and other…”
Get full text

Requirements for Follicular Exclusion and Competitive Elimination of Autoantigen-Binding B Cells by Ekland, Eric H, Forster, Reinhold, Lipp, Martin, Cyster, Jason G

“…Results from several mouse tolerance models indicate that autoreactive B cells in peripheral lymphoid organs develop an anergic phenotype, migrate to the…”
Get full text

Identifying apicoplast‐targeting antimalarials using high‐throughput compatible approaches by Ekland, Eric H., Schneider, Jessica, Fidock, David A.

“…ABSTRACT Malarial parasites have evolved resistance to all previously used therapies, and recent evidence suggests emerging resistance to the first‐line…”
Get full text

In vitro and in vivo activity of frenolicin B against Plasmodium falciparum and P berghei by Fitzgerald, Jay T, Henrich, Philipp P, O'Brien, Connor, Krause, Michael, Ekland, Eric H, Mattheis, Corinna, Sá, Juliana M, Fidock, David, Khosla, Chaitan

Get full text

Structurally Complex and Highly Active RNA Ligases Derived from Random RNA Sequences by Ekland, Eric H., Szostak, Jack W., Bartel, David P.

“…Seven families of RNA ligases, previously isolated from random RNA sequences, fall into three classes on the basis of secondary structure and regiospecificity…”
Get full text

Advances in understanding the genetic basis of antimalarial drug resistance by Ekland, Eric H, Fidock, David A

“…The acquisition of drug resistance by Plasmodium falciparum has severely curtailed global efforts to control malaria. Our ability to define resistance has been…”
Get full text

In vitro evaluations of antimalarial drugs and their relevance to clinical outcomes by Ekland, Eric H., Fidock, David A.

“…Plasmodium falciparum resistance to the former first-line antimalarials chloroquine and sulfadoxine/pyrimethamine has reached critically high levels in many…”
Get full text

Origin of robustness in generating drug-resistant malaria parasites by Kümpornsin, Krittikorn, Modchang, Charin, Heinberg, Adina, Ekland, Eric H, Jirawatcharadech, Piyaporn, Chobson, Pornpimol, Suwanakitti, Nattida, Chaotheing, Sastra, Wilairat, Prapon, Deitsch, Kirk W, Kamchonwongpaisan, Sumalee, Fidock, David A, Kirkman, Laura A, Yuthavong, Yongyuth, Chookajorn, Thanat

“…Biological robustness allows mutations to accumulate while maintaining functional phenotypes. Despite its crucial role in evolutionary processes, the…”
Get full text

Balanced responsiveness to chemoattractants from adjacent zones determines B-cell position by Cyster, Jason G, Reif, Karin, Ekland, Eric H, Ohl, Lars, Nakano, Hideki, Lipp, Martin, Förster, Reinhold

“…B lymphocytes re-circulate between B-cell-rich compartments (follicles or B zones) in secondary lymphoid organs, surveying for antigen. After antigen binding,…”
Get full text

Tricks in Plasmodium's molecular repertoire ― Escaping 3'UTR excision-based conditional silencing of the chloroquine resistance transporter gene by ECKER, Andrea, LEWIS, Rebecca E, EKLAND, Eric H, JAYABALASINGHAM, Bamini, FIDOCK, David A

“…In the human malaria parasite Plasmodium falciparum, the major determinant of chloroquine resistance, P. falciparum chloroquine resistance transporter (pfcrt),…”
Get full text

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1 by Cyster, Jason G, Gunn, Michael D, Ngo, Vu N, Ansel, K. Mark, Ekland, Eric H, Williams, Lewis T

“…Secondary lymphoid organs (spleen, lymph nodes and Peyer's patches) are divided into compartments, such as B-cell zones (follicles) and T-cell zones, which…”
Get full text

Diversity-Oriented Synthesis Yields a Novel Lead for the Treatment of Malaria by Heidebrecht, Richard W, Mulrooney, Carol, Austin, Christopher P, Barker, Robert H, Beaudoin, Jennifer A, Cheng, Ken Chih-Chien, Comer, Eamon, Dandapani, Sivaraman, Dick, Justin, Duvall, Jeremy R, Ekland, Eric H, Fidock, David A, Fitzgerald, Mark E, Foley, Michael, Guha, Rajarshi, Hinkson, Paul, Kramer, Martin, Lukens, Amanda K, Masi, Daniela, Marcaurelle, Lisa A, Su, Xin-Zhuan, Thomas, Craig J, Weïwer, Michel, Wiegand, Roger C, Wirth, Dyann, Xia, Menghang, Yuan, Jing, Zhao, Jinghua, Palmer, Michelle, Munoz, Benito, Schreiber, Stuart

“…Here, we describe the discovery of a novel antimalarial agent using phenotypic screening of Plasmodium falciparum asexual blood-stage parasites. Screening a…”
Get full text

Recognition of Nucleoside Triphosphates during RNA-Catalyzed Primer Extension by Glasner, Margaret E, Yen, Catherine C, Ekland, Eric H, Bartel, David P

“…In support of the idea that certain RNA molecules might be able to catalyze RNA replication, a ribozyme was previously generated that synthesizes short…”
Get full text

RNA-catalysed RNA polymerization using nucleoside triphosphates by Ekland, Eric H, Bartel, David P

“…The hypothesis that certain RNA molecules may be able to catalyse RNA replication is central to current theories of the early evolution of life. In support of…”
Get full text