Search Results - "Ekiz, H"

T cell-mediated regulation of the microbiota protects against obesity by Petersen, Charisse, Bell, Rickesha, Klag, Kendra A, Lee, Soh-Hyun, Soto, Raymond, Ghazaryan, Arevik, Buhrke, Kaitlin, Ekiz, H Atakan, Ost, Kyla S, Boudina, Sihem, O'Connell, Ryan M, Cox, James E, Villanueva, Claudio J, Stephens, W Zac, Round, June L

“…The microbiota influences obesity, yet organisms that protect from disease remain unknown. During studies interrogating host-microbiota interactions, we…”
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Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus by Syage, Amber R, Ekiz, H Atakan, Skinner, Dominic D, Stone, Colleen, O'Connell, Ryan M, Lane, Thomas E

“…Intracranial (i.c.) infection of susceptible C57BL/6 mice with the neurotropic JHM strain of mouse hepatitis virus (JHMV) (a member of the family) results in…”
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CIPR: a web-based R/shiny app and R package to annotate cell clusters in single cell RNA sequencing experiments by Ekiz, H Atakan, Conley, Christopher J, Stephens, W Zac, O'Connell, Ryan M

“…Single cell RNA sequencing (scRNAseq) has provided invaluable insights into cellular heterogeneity and functional states in health and disease. During the…”
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A Stat1 bound enhancer promotes Nampt expression and function within tumor associated macrophages by Huffaker, Thomas B., Ekiz, H. Atakan, Barba, Cindy, Lee, Soh-Hyun, Runtsch, Marah C., Nelson, Morgan C., Bauer, Kaylyn M., Tang, William W., Mosbruger, Timothy L., Cox, James E., Round, June L., Voth, Warren P., O’Connell, Ryan M.

“…Tumor associated macrophage responses are regulated by distinct metabolic states that affect their function. However, the ability of specific signals in the…”
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Maternal schistosomiasis impairs offspring Interleukin-4 production and B cell expansion by Cortés-Selva, Diana, Gibbs, Lisa, Ready, Andrew, Ekiz, H Atakan, O'Connell, Ryan, Rajwa, Bartek, Fairfax, Keke C

“…Epidemiological studies have identified a correlation between maternal helminth infections and reduced immunity to some early childhood vaccinations, but the…”
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Utilizing fab fragment‐conjugated surface plasmon resonance‐based biosensor for detection of Salmonella Enteritidis by Eser, Esma, Ekiz, Okan Öner, Ekiz, H. İbrahim

“…Although antibodies, a key element of biorecognition, are frequently used as biosensor probes, the use of these large molecules can lead to adverse effects…”
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An immune-humanized patient-derived xenograft model of estrogen-independent, hormone receptor positive metastatic breast cancer by Scherer, Sandra D, Riggio, Alessandra I, Haroun, Fadi, DeRose, Yoko S, Ekiz, H Atakan, Fujita, Maihi, Toner, Jennifer, Zhao, Ling, Li, Zheqi, Oesterreich, Steffi, Samatar, Ahmed A, Welm, Alana L

“…Metastatic breast cancer (MBC) is incurable, with a 5-year survival rate of 28%. In the USA, more than 42,000 patients die from MBC every year. The most common…”
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Microglia influence host defense, disease, and repair following murine coronavirus infection of the central nervous system by Mangale, Vrushali, Syage, Amber R., Ekiz, H. Atakan, Skinner, Dominic D., Cheng, Yuting, Stone, Colleen L., Brown, R. Marshall, O'Connell, Ryan M., Green, Kim N., Lane, Thomas E.

“…The present study examines functional contributions of microglia in host defense, demyelination, and remyelination following infection of susceptible mice with…”
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Blocking Short-Form Ron Eliminates Breast Cancer Metastases through Accumulation of Stem-Like CD4+ T Cells That Subvert Immunosuppression by Lai, Shu-Chin Alicia, Gundlapalli, Harika, Ekiz, H Atakan, Jiang, Amanda, Fernandez, Elvelyn, Welm, Alana L

“…Immunotherapy has potential to prevent and treat metastatic breast cancer, but strategies to enhance immune-mediated killing of metastatic tumors are urgently…”
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Mitochondrial Pyruvate Carrier 1 Promotes Peripheral T Cell Homeostasis through Metabolic Regulation of Thymic Development by Ramstead, Andrew G., Wallace, Jared A., Lee, Soh-Hyun, Bauer, Kaylyn M., Tang, William W., Ekiz, H. Atakan, Lane, Thomas E., Cluntun, Ahmad A., Bettini, Matthew L., Round, June L., Rutter, Jared, O’Connell, Ryan M.

“…Metabolic pathways regulate T cell development and function, but many remain understudied. Recently, the mitochondrial pyruvate carrier (MPC) was identified as…”
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A single-amino acid substitution in the adaptor LAT accelerates TCR proofreading kinetics and alters T-cell selection, maintenance and function by Lo, Wan-Lin, Kuhlmann, Miriam, Rizzuto, Gabrielle, Ekiz, H. Atakan, Kolawole, Elizabeth M., Revelo, Monica P., Andargachew, Rakieb, Li, Zhongmei, Tsai, Yuan-Li, Marson, Alexander, Evavold, Brian D., Zehn, Dietmar, Weiss, Arthur

“…Mature T cells must discriminate between brief interactions with self-peptides and prolonged binding to agonists. The kinetic proofreading model posits that…”
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Tumour-intrinsic endomembrane trafficking by ARF6 shapes an immunosuppressive microenvironment that drives melanomagenesis and response to checkpoint blockade therapy by Wee, Yinshen, Wang, Junhua, Wilson, Emily C., Rich, Coulson P., Rogers, Aaron, Tong, Zongzhong, DeGroot, Evelyn, Gopal, Y. N. Vashisht, Davies, Michael A., Ekiz, H. Atakan, Tay, Joshua K. H., Stubben, Chris, Boucher, Kenneth M., Oviedo, Juan M., Fairfax, Keke C., Williams, Matthew A., Holmen, Sheri L., Wolff, Roger K., Grossmann, Allie H.

“…Tumour-host immune interactions lead to complex changes in the tumour microenvironment (TME), impacting progression, metastasis and response to therapy. While…”
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MicroRNA-155 Plays Selective Cell-Intrinsic Roles in Brain-Infiltrating Immune Cell Populations during Neuroinflammation by Thompson, Jacob W, Hu, Ruozhen, Huffaker, Thomas B, Ramstead, Andrew G, Ekiz, H Atakan, Bauer, Kaylyn M, Tang, William W, Ghazaryan, Arevik, Round, June L, Fujinami, Robert S, O'Connell, Ryan M

“…The proinflammatory microRNA-155 (miR-155) is highly expressed in the serum and CNS lesions of patients with multiple sclerosis (MS). Global knockout (KO) of…”
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Epithelial-myeloid exchange of MHC class II constrains immunity and microbiota composition by Stephens, W. Zac, Kubinak, Jason L., Ghazaryan, Arevik, Bauer, Kaylyn M., Bell, Rickesha, Buhrke, Kate, Chiaro, Tyson R., Weis, Allison M., Tang, William W., Monts, Josh K., Soto, Ray, Ekiz, H. Atakan, O’Connell, Ryan M., Round, June L.

“…Intestinal epithelial cells (IECs) have long been understood to express high levels of major histocompatibility complex class II (MHC class II) molecules but…”
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T Cell-Expressed microRNA-155 Reduces Lifespan in a Mouse Model of Age-Related Chronic Inflammation by Ekiz, H Atakan, Ramstead, Andrew G, Lee, Soh-Hyun, Nelson, Morgan C, Bauer, Kaylyn M, Wallace, Jared A, Hu, Ruozhen, Round, June L, Rutter, Jared, Drummond, Micah J, Rao, Dinesh S, O'Connell, Ryan M

“…Aging-related chronic inflammation is a risk factor for many human disorders through incompletely understood mechanisms. Aged mice deficient in microRNA…”
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Effect of Ultraviolet and Far Infrared Radiation on Microbial Decontamination and Quality of Cumin Seeds by Erdoğdu, S. Belgin, Ekiz, H. İbrahim

“…:  Cumin seeds might be exposed to a high level of natural bacterial contamination, and this could potentially create a public health risk besides leading to…”
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Disrupted macrophage metabolic reprogramming in aged soleus muscle during early recovery following disuse atrophy by Fix, Dennis K., Ekiz, H. Atakan, Petrocelli, Jonathan J., Mckenzie, Alec M., Mahmassani, Ziad S., O'Connell, Ryan M., Drummond, Micah J.

“…Aged skeletal muscle is characterized by poor muscle recovery following disuse coinciding with an impaired muscle pro‐inflammatory macrophage response…”
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Sliding friction and wear behaviour of polytetrafluoroethylene and its composites under dry conditions by Unal, H., Mimaroglu, A., Kadıoglu, U., Ekiz, H.

“…In this paper, we studied and explored the influence of test speed and load values on the friction and wear behaviour of pure polytetrafluoroethylene (PTFE),…”
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MicroRNA-155 coordinates the immunological landscape within murine melanoma and correlates with immunity in human cancers by Ekiz, H Atakan, Huffaker, Thomas B, Grossmann, Allie H, Stephens, W Zac, Williams, Matthew A, Round, June L, O'Connell, Ryan M

“…miR-155 has recently emerged as an important promoter of antitumor immunity through its functions in T lymphocytes. However, the impact of T cell-expressed…”
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Interferon Gamma-Inducible NAMPT in Melanoma Cells Serves as a Mechanism of Resistance to Enhance Tumor Growth by Barba, Cindy, Ekiz, H Atakan, Tang, William Weihao, Ghazaryan, Arevik, Hansen, Mason, Lee, Soh-Hyun, Voth, Warren Peter, O'Connell, Ryan Michael

“…(1) Background: Immune cells infiltrate the tumor microenvironment and secrete inflammatory cytokines, including interferons (IFNs), to drive antitumor…”
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