Search Results - "Ekim Ustunel, Bilgen"

The IKK‐related kinase TBK1 activates mTORC1 directly in response to growth factors and innate immune agonists by Bodur, Cagri, Kazyken, Dubek, Huang, Kezhen, Ekim Ustunel, Bilgen, Siroky, Kate A, Tooley, Aaron Seth, Gonzalez, Ian E, Foley, Daniel H, Acosta‐Jaquez, Hugo A, Barnes, Tammy M, Steinl, Gabrielle K, Cho, Kae‐Won, Lumeng, Carey N, Riddle, Steven M, Myers, Martin G, Fingar, Diane C

“…The innate immune kinase TBK1 initiates inflammatory responses to combat infectious pathogens by driving production of type I interferons. TBK1 also controls…”
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Emerging Targets in Type 2 Diabetes and Diabetic Complications by Demir, Sevgican, Nawroth, Peter P., Herzig, Stephan, Ekim Üstünel, Bilgen

“…Type 2 diabetes is a metabolic, chronic disorder characterized by insulin resistance and elevated blood glucose levels. Although a large drug portfolio exists…”
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Endothelial Notch signaling controls insulin transport in muscle by Hasan, Sana S, Jabs, Markus, Taylor, Jacqueline, Wiedmann, Lena, Leibing, Thomas, Nordström, Viola, Federico, Giuseppina, Roma, Leticia P, Carlein, Christopher, Wolff, Gretchen, Ekim‐Üstünel, Bilgen, Brune, Maik, Moll, Iris, Tetzlaff, Fabian, Gröne, Hermann‐Josef, Fleming, Thomas, Géraud, Cyrill, Herzig, Stephan, Nawroth, Peter P, Fischer, Andreas

“…The role of the endothelium is not just limited to acting as an inert barrier for facilitating blood transport. Endothelial cells (ECs), through expression of…”
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Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication by Loft, Anne, Alfaro, Ana Jimena, Schmidt, Søren Fisker, Pedersen, Felix Boel, Terkelsen, Mike Krogh, Puglia, Michele, Chow, Kan Kau, Feuchtinger, Annette, Troullinaki, Maria, Maida, Adriano, Wolff, Gretchen, Sakurai, Minako, Berutti, Riccardo, Ekim Üstünel, Bilgen, Nawroth, Peter, Ravnskjaer, Kim, Diaz, Mauricio Berriel, Blagoev, Blagoy, Herzig, Stephan

“…Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-associated fatty liver disease; yet, the mechanisms underlying the…”
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TSC22D4 interacts with Akt1 to regulate glucose metabolism by Demir, Sevgican, Wolff, Gretchen, Wieder, Annika, Maida, Adriano, Bühler, Lea, Brune, Maik, Hautzinger, Oksana, Feuchtinger, Annette, Poth, Tanja, Szendroedi, Julia, Herzig, Stephan, Ekim Üstünel, Bilgen

“…Maladaptive insulin signaling is a key feature in the pathogenesis of severe metabolic disorders, including obesity and diabetes. Enhancing insulin sensitivity…”
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Control of diabetic hyperglycaemia and insulin resistance through TSC22D4 by Ekim Üstünel, Bilgen, Friedrich, Kilian, Maida, Adriano, Wang, Xiaoyue, Krones-Herzig, Anja, Seibert, Oksana, Sommerfeld, Anke, Jones, Allan, Sijmonsma, Tjeerd P., Sticht, Carsten, Gretz, Norbert, Fleming, Thomas, Nawroth, Peter P., Stremmel, Wolfgang, Rose, Adam J., Berriel-Diaz, Mauricio, Blüher, Matthias, Herzig, Stephan

“…Obesity-related insulin resistance represents the core component of the metabolic syndrome, promoting glucose intolerance, pancreatic beta cell failure and…”
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Lipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control by Bühler, Lea, Maida, Adriano, Vogl, Elena Sophie, Georgiadi, Anastasia, Takacs, Andrea, Kluth, Oliver, Schürmann, Annette, Feuchtinger, Annette, von Toerne, Christine, Tsokanos, Foivos-Filippos, Klepac, Katarina, Wolff, Gretchen, Sakurai, Minako, Ekim Üstünel, Bilgen, Nawroth, Peter, Herzig, Stephan

“…Members of the lipocalin protein family serve as biomarkers for kidney disease and acute phase inflammatory reactions, and are under preclinical development…”
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A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage by Niopek, Katharina, Üstünel, Bilgen Ekim, Seitz, Susanne, Sakurai, Minako, Zota, Annika, Mattijssen, Frits, Wang, Xiaoyue, Sijmonsma, Tjeerd, Feuchter, Yvonne, Gail, Anna M., Leuchs, Barbara, Niopek, Dominik, Staufer, Oskar, Brune, Maik, Sticht, Carsten, Gretz, Norbert, Müller-Decker, Karin, Hammes, Hans-Peter, Nawroth, Peter, Fleming, Thomas, Conkright, Michael D., Blüher, Matthias, Zeigerer, Anja, Herzig, Stephan, Berriel Diaz, Mauricio

“…Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling…”
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TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells by Sakurai, Minako, Weber, Peter, Wolff, Gretchen, Wieder, Annika, Szendroedi, Julia, Herzig, Stephan, Ekim Üstünel, Bilgen

“…Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and liver fibrosis emerge as progressive liver diseases that accompany…”
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Novel Regulation of mTOR Complex 1 Signaling by Site-Specific mTOR Phosphorylation by Ustunel, Bilgen Ekim

“…Aberrant regulation of the kinase mTOR (mammalian target of rapamycin) within mTOR complex 1 (mTORC1) contributes to several pathologic states including…”
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An AMP-activated protein kinase–stabilizing peptide ameliorates adipose tissue wasting in cancer cachexia in mice by Rohm, Maria, Schäfer, Michaela, Laurent, Victor, Üstünel, Bilgen Ekim, Niopek, Katharina, Algire, Carolyn, Hautzinger, Oksana, Sijmonsma, Tjeerd P, Zota, Annika, Medrikova, Dasa, Pellegata, Natalia S, Ryden, Mikael, Kulyte, Agné, Dahlman, Ingrid, Arner, Peter, Petrovic, Natasa, Cannon, Barbara, Amri, Ez-Zoubir, Kemp, Bruce E, Steinberg, Gregory R, Janovska, Petra, Kopecky, Jan, Wolfrum, Christian, Blüher, Matthias, Berriel Diaz, Mauricio, Herzig, Stephan

“…Cancer cachexia is marked by a pathological loss of fat tissue, but preventing the degradation of AMPK in this tissue helps preserve its mass in mouse models…”
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Semaphorin 3C exacerbates liver fibrosis by De Angelis Rigotti, Francesca, Wiedmann, Lena, Hubert, Max Ole, Vacca, Margherita, Hasan, Sana S, Moll, Iris, Carvajal, Silvia, Jiménez, Wladimiro, Starostecka, Maja, Billeter, Adrian T, Müller-Stich, Beat, Wolff, Gretchen, Ekim-Üstünel, Bilgen, Herzig, Stephan, Fandos-Ramo, Cristina, Krätzner, Ralph, Reich, Maria, Keitel-Anselmino, Verena, Heikenwälder, Mathias, Mogler, Carolin, Fischer, Andreas, Rodriguez-Vita, Juan

“…Chronic liver disease is a growing epidemic, leading to fibrosis and cirrhosis. TGF-β is the pivotal profibrogenic cytokine that activates HSC, yet other…”
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Hepatocyte-specific activity of TSC22D4 triggers progressive NAFLD by impairing mitochondrial function by Wolff, Gretchen, Sakurai, Minako, Mhamane, Amit, Troullinaki, Maria, Maida, Adriano, Deligiannis, Ioannis K., Yin, Kelvin, Weber, Peter, Morgenstern, Jakob, Wieder, Annika, Kwon, Yun, Sekar, Revathi, Zeigerer, Anja, Roden, Michael, Blüher, Matthias, Volk, Nadine, Poth, Tanja, Hackert, Thilo, Wiedmann, Lena, De Angelis Rigotti, Francesca, Rodriguez-Vita, Juan, Fischer, Andreas, Mukthavaram, Rajesh, Limphong, Pattraranee, Tachikawa, Kiyoshi, Karmali, Priya, Payne, Joseph, Chivukula, Padmanabh, Ekim-Üstünel, Bilgen, Martinez-Jimenez, Celia P., Szendrödi, Julia, Nawroth, Peter, Herzig, Stephan

“…Fibrotic organ responses have recently been identified as long-term complications in diabetes. Indeed, insulin resistance and aberrant hepatic lipid…”
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