Search Results - "Eketjall, Susanna"

High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus by Oke, Vilija, Gunnarsson, Iva, Dorschner, Jessica, Eketjäll, Susanna, Zickert, Agneta, Niewold, Timothy B, Svenungsson, Elisabet

“…Interferons (IFNs) are considered to be key molecules in the pathogenesis of systemic lupus erythematosus (SLE). We measured levels of type I, II and III IFNs…”
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Sjögren Syndrome in Systemic Lupus Erythematosus: A Subset Characterized by a Systemic Inflammatory State by Ruacho, Guillermo, Kvarnström, Marika, Zickert, Agneta, Oke, Vilija, Rönnelid, Johan, Eketjäll, Susanna, Elvin, Kerstin, Gunnarsson, Iva, Svenungsson, Elisabet

“…An often-neglected subset of patients with systemic lupus erythematosus (SLE) is those with secondary Sjögren syndrome (SLE-sSS). Further, primary SS overlaps…”
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TREM2 shedding by cleavage at the H157‐S158 bond is accelerated for the Alzheimer's disease‐associated H157Y variant by Thornton, Peter, Sevalle, Jean, Deery, Michael J, Fraser, Graham, Zhou, Ye, Ståhl, Sara, Franssen, Elske H, Dodd, Roger B, Qamar, Seema, Gomez Perez‐Nievas, Beatriz, Nicol, Louise SC, Eketjäll, Susanna, Revell, Jefferson, Jones, Clare, Billinton, Andrew, St George‐Hyslop, Peter H, Chessell, Iain, Crowther, Damian C

“…We have characterised the proteolytic cleavage events responsible for the shedding of triggering receptor expressed on myeloid cells 2 (TREM2) from primary…”
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Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus by Torell, Frida, Eketjäll, Susanna, Idborg, Helena, Jakobsson, Per-Johan, Gunnarsson, Iva, Svenungsson, Elisabet, Trygg, Johan

“…The aim of this study was to evaluate how the cytokine profiles differed between autoantibody based subgroups of systemic lupus erythematosus (SLE). SLE is a…”
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Discovery of AZD3839, a Potent and Selective BACE1 Inhibitor Clinical Candidate for the Treatment of Alzheimer Disease by Jeppsson, Fredrik, Eketjäll, Susanna, Janson, Juliette, Karlström, Sofia, Gustavsson, Susanne, Olsson, Lise-Lotte, Radesäter, Ann-Cathrine, Ploeger, Bart, Cebers, Gvido, Kolmodin, Karin, Swahn, Britt-Marie, von Berg, Stefan, Bueters, Tjerk, Fälting, Johanna

“…β-Site amyloid precursor protein cleaving enzyme1 (BACE1) is one of the key enzymes involved in the processing of the amyloid precursor protein (APP) and…”
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Microparticles in the blood of patients with SLE: Size, content of mitochondria and role in circulating immune complexes by Mobarrez, Fariborz, Fuzzi, Enrico, Gunnarsson, Iva, Larsson, Anders, Eketjäll, Susanna, Pisetsky, David S., Svenungsson, Elisabet

“…Microparticles (MPs) are small extracellular vesicles released from apoptotic or activated cells through a blebbing process. MPs express surface molecules from…”
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AZD3293: A Novel, Orally Active BACE1 Inhibitor with High Potency and Permeability and Markedly Slow Off-Rate Kinetics by Eketjäll, Susanna, Janson, Juliette, Kaspersson, Karin, Bogstedt, Anna, Jeppsson, Fredrik, Fälting, Johanna, Haeberlein, Samantha Budd, Kugler, Alan R, Alexander, Robert C, Cebers, Gvido

“…A growing body of pathological, biomarker, genetic, and mechanistic data suggests that amyloid accumulation, as a result of changes in production, processing,…”
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Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease by Davidsson, Pia, Eketjäll, Susanna, Eriksson, Niclas, Walentinsson, Anna, Becker, Richard C, Cavallin, Anders, Bogstedt, Anna, Collén, Anna, Held, Claes, James, Stefan, Siegbahn, Agneta, Stewart, Ralph, Storey, Robert F, White, Harvey, Wallentin, Lars

“…Abstract Aims The vascular endothelial growth factor (VEGF) family is involved in pathophysiological mechanisms underlying cardiovascular (CV) diseases. The…”
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Development of a highly sensitive liquid chromatography - mass spectrometry method to quantify plasma leukotriene E 4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man by Löfgren, Lars, Forsberg, Gun-Britt, Davidsson, Pia, Eketjäll, Susanna, Whatling, Carl

“…Low basal endogenous concentrations (< 20 pg/mL) of the 5-lipoxygenase (5-LO) pathway biomarker leukotriene E (LTE ) in human plasma present a significant…”
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Toward β‑Secretase‑1 Inhibitors with Improved Isoform Selectivity by Johansson, Patrik, Kaspersson, Karin, Gurrell, Ian K, Bäck, Elisabeth, Eketjäll, Susanna, Scott, Clay W, Cebers, Gvido, Thorne, Philip, McKenzie, Michael J, Beaton, Haydn, Davey, Paul, Kolmodin, Karin, Holenz, Jörg, Duggan, Mark E, Budd Haeberlein, Samantha, Bürli, Roland W

“…BACE1 is responsible for the first step in APP proteolysis, leading to toxic Aβ production, and has been indicated to play a key role in the pathogenesis of…”
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New Aminoimidazoles as β‑Secretase (BACE-1) Inhibitors Showing Amyloid‑β (Aβ) Lowering in Brain by Gravenfors, Ylva, Viklund, Jenny, Blid, Jan, Ginman, Tobias, Karlström, Sofia, Kihlström, Jacob, Kolmodin, Karin, Lindström, Johan, von Berg, Stefan, von Kieseritzky, Fredrik, Slivo, Can, Swahn, Britt-Marie, Olsson, Lise-Lotte, Johansson, Patrik, Eketjäll, Susanna, Fälting, Johanna, Jeppsson, Fredrik, Strömberg, Kia, Janson, Juliette, Rahm, Fredrik

“…Amino-2H-imidazoles are described as a new class of BACE-1 inhibitors for the treatment of Alzheimer’s disease. Synthetic methods, crystal structures, and…”
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Design and Synthesis of β‑Site Amyloid Precursor Protein Cleaving Enzyme (BACE1) Inhibitors with in Vivo Brain Reduction of β‑Amyloid Peptides by Swahn, Britt-Marie, Kolmodin, Karin, Karlström, Sofia, von Berg, Stefan, Söderman, Peter, Holenz, Jörg, Berg, Stefan, Lindström, Johan, Sundström, Marie, Turek, Dominika, Kihlström, Jacob, Slivo, Can, Andersson, Lars, Pyring, David, Rotticci, Didier, Öhberg, Liselotte, Kers, Annika, Bogar, Krisztian, von Kieseritzky, Fredrik, Bergh, Margareta, Olsson, Lise-Lotte, Janson, Juliette, Eketjäll, Susanna, Georgievska, Biljana, Jeppsson, Fredrik, Fälting, Johanna

“…The evaluation of a series of aminoisoindoles as β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors and the discovery of a clinical…”
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AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease by Cebers, Gvido, Alexander, Robert C, Haeberlein, Samantha Budd, Han, David, Goldwater, Ronald, Ereshefsky, Larry, Olsson, Tina, Ye, Naidong, Rosen, Laura, Russell, Muir, Maltby, Justine, Eketjäll, Susanna, Kugler, Alan R

“…AZD3293 (LY3314814) is a promising new potentially disease-modifying BACE1 (β-secretase) inhibitor in Phase III clinical development for the treatment of…”
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Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis by Leonard, Dag, Svenungsson, Elisabet, Dahlqvist, Johanna, Alexsson, Andrei, Ärlestig, Lisbeth, Taylor, Kimberly E, Sandling, Johanna K, Bengtsson, Christine, Frodlund, Martina, Jönsen, Andreas, Eketjäll, Susanna, Jensen-Urstad, Kerstin, Gunnarsson, Iva, Sjöwall, Christopher, Bengtsson, Anders A, Eloranta, Maija-Leena, Syvänen, Ann-Christine, Rantapää-Dahlqvist, Solbritt, Criswell, Lindsey A, Rönnblom, Lars

“…Patients with systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) have increased risk of cardiovascular disease (CVD). We investigated whether…”
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Highly sensitive and specific LC–MS/MS method to determine endogenous leukotriene B4 levels in human plasma by Bhat, Maria, Lindgren, Anna, Eketjäll, Susanna, Hidi, Rabia, Schatz, Philipp, Whatling, Carl, Fidock, Mark

“…To develop a high sensitivity and specific analytical method to measure endogenous levels of leukotriene B4 (LTB ) in human plasma. LC–MS/MS and ELISA. An…”
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MEDI1814 selectively reduces free Aβ42 in cerebrospinal fluid of non‐clinical species and Alzheimer's disease patients by Lloyd, Christopher, Freskgård, Per‐Ola, Newton, Philip, Lowne, David, Nickson, Adrian, Bogstedt, Anna, Eketjäll, Susanna, Höglund, Kina, Gustavsson, Susanne, Welsh, Fraser, Chessell, Tharani, McFarlane, Mary, Bhat, Ratan V., Turner, Richard, Perkinton, Michael S., Santisteban Valencia, Zulma, Lindqvist, Eva, Pomfret, Michael, Dudley, Amanda D., Vaughan, Tristan J., Groves, Maria T., Natanegara, Fanni, Feng, Yingdong, Sims, John R., Proctor, Nicholas Kyle, Dage, Jeffrey L., Shering, Craig, Tan, Keith, Ostenfeld, Thor, Billinton, Andy, Chessell, Iain P.

“…INTRODUCTION Small molecules and antibodies are being developed to lower amyloid beta (Aβ) peptides. METHODS We describe MEDI1814, a fully human high‐affinity…”
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TNF-α and plasma albumin as biomarkers of disease activity in systemic lupus erythematosus by Idborg, Helena, Eketjäll, Susanna, Pettersson, Susanne, Gustafsson, Johanna T, Zickert, Agneta, Kvarnström, Marika, Oke, Vilija, Jakobsson, Per-Johan, Gunnarsson, Iva, Svenungsson, Elisabet

“…ObjectivesComposite criteria/indices are presently used to diagnose and monitor patients with systemic lupus erythematosus (SLE). Biomarkers for these purposes…”
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Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter β‐amyloid levels in the CNS by Georgievska, Biljana, Gustavsson, Susanne, Lundkvist, Johan, Neelissen, Jan, Eketjäll, Susanna, Ramberg, Veronica, Bueters, Tjerk, Agerman, Karin, Juréus, Anders, Svensson, Samuel, Berg, Stefan, Fälting, Johanna, Lendahl, Urban

“…Aggregation of amyloid beta (Aβ) peptides and the subsequent neural plaque formation is a central aspect of Alzheimer's disease. Various strategies to reduce…”
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Determining myeloperoxidase activity and protein concentration in a single assay: Utility in biomarker and therapeutic studies by Russell, Muir, Prokoph, Nina, Henderson, Neil, Eketjäll, Susanna, Balendran, Clare A., Michaëlsson, Erik, Fidock, Mark, Hughes, Glen

“…Myeloperoxidase (MPO) is predominantly expressed by neutrophils and is an important enzyme used by the immune system for the neutralisation of bacteria and…”
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Kynurenine pathway is altered in patients with SLE and associated with severe fatigue by Åkesson, Karolina, Pettersson, Susanne, Ståhl, Sara, Surowiec, Izabella, Hedenström, Mattias, Eketjäll, Susanna, Trygg, Johan, Jakobsson, Per-Johan, Gunnarsson, Iva, Svenungsson, Elisabet, Idborg, Helena

“…ObjectiveFatigue has been reported as the most disturbing symptom in a majority of patients with SLE. Depression is common and often severe. Together these…”
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