Search Results - "Ekert, Paul G."

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma by Hassannia, Behrouz, Wiernicki, Bartosz, Ingold, Irina, Qu, Feng, Van Herck, Simon, Tyurina, Yulia Y, Bayır, Hülya, Abhari, Behnaz A, Angeli, Jose Pedro Friedmann, Choi, Sze Men, Meul, Eline, Heyninck, Karen, Declerck, Ken, Chirumamilla, Chandra Sekhar, Lahtela-Kakkonen, Maija, Van Camp, Guy, Krysko, Dmitri V, Ekert, Paul G, Fulda, Simone, De Geest, Bruno G, Conrad, Marcus, Kagan, Valerian E, Vanden Berghe, Wim, Vandenabeele, Peter, Vanden Berghe, Tom

“…High-risk neuroblastoma is a devastating malignancy with very limited therapeutic options. Here, we identify withaferin A (WA) as a natural…”
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Reprogrammed CRISPR-Cas13b suppresses SARS-CoV-2 replication and circumvents its mutational escape through mismatch tolerance by Fareh, Mohamed, Zhao, Wei, Hu, Wenxin, Casan, Joshua M. L., Kumar, Amit, Symons, Jori, Zerbato, Jennifer M., Fong, Danielle, Voskoboinik, Ilia, Ekert, Paul G., Rudraraju, Rajeev, Purcell, Damian F. J., Lewin, Sharon R., Trapani, Joseph A.

“…The recent dramatic appearance of variants of concern of SARS-coronavirus-2 (SARS-CoV-2) highlights the need for innovative approaches that simultaneously…”
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The molecular relationships between apoptosis, autophagy and necroptosis by Lalaoui, Najoua, Lindqvist, Lisa M., Sandow, Jarrod J., Ekert, Paul G.

“…Cells are constantly subjected to a vast range of potentially lethal insults, which may activate specific molecular pathways that have evolved to kill the…”
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RIPK1 Regulates RIPK3-MLKL-Driven Systemic Inflammation and Emergency Hematopoiesis by Rickard, James A., O’Donnell, Joanne A., Evans, Joseph M., Lalaoui, Najoua, Poh, Ashleigh R., Rogers, TeWhiti, Vince, James E., Lawlor, Kate E., Ninnis, Robert L., Anderton, Holly, Hall, Cathrine, Spall, Sukhdeep K., Phesse, Toby J., Abud, Helen E., Cengia, Louise H., Corbin, Jason, Mifsud, Sandra, Di Rago, Ladina, Metcalf, Donald, Ernst, Matthias, Dewson, Grant, Roberts, Andrew W., Alexander, Warren S., Murphy, James M., Ekert, Paul G., Masters, Seth L., Vaux, David L., Croker, Ben A., Gerlic, Motti, Silke, John

“…Upon ligand binding, RIPK1 is recruited to tumor necrosis factor receptor superfamily (TNFRSF) and Toll-like receptor (TLR) complexes promoting prosurvival and…”
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JAFFAL: detecting fusion genes with long-read transcriptome sequencing by Davidson, Nadia M, Chen, Ying, Sadras, Teresa, Ryland, Georgina L, Blombery, Piers, Ekert, Paul G, Göke, Jonathan, Oshlack, Alicia

“…In cancer, fusions are important diagnostic markers and targets for therapy. Long-read transcriptome sequencing allows the discovery of fusions with their…”
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MINTIE: identifying novel structural and splice variants in transcriptomes using RNA-seq data by Cmero, Marek, Schmidt, Breon, Majewski, Ian J, Ekert, Paul G, Oshlack, Alicia, Davidson, Nadia M

“…Calling fusion genes from RNA-seq data is well established, but other transcriptional variants are difficult to detect using existing approaches. To identify…”
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Brief Report: Potent clinical and radiological response to larotrectinib in TRK fusion-driven high-grade glioma by Ziegler, David S., Wong, Marie, Mayoh, Chelsea, Kumar, Amit, Tsoli, Maria, Mould, Emily, Tyrrell, Vanessa, Khuong-Quang, Dong-Anh, Pinese, Mark, Gayevskiy, Velimir, Cohn, Richard J., Lau, Loretta M. S., Reynolds, Mark, Cox, Michael C., Gifford, Andrew, Rodriguez, Michael, Cowley, Mark J., Ekert, Paul G., Marshall, Glenn M., Haber, Michelle

“…Genes encoding TRK are oncogenic drivers in multiple tumour types including infantile fibrosarcoma, papillary thyroid cancer and high-grade gliomas (HGG). TRK…”
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The granulocyte-macrophage colony-stimulating factor receptor: linking its structure to cell signaling and its role in disease by Hercus, Timothy R., Thomas, Daniel, Guthridge, Mark A., Ekert, Paul G., King-Scott, Jack, Parker, Michael W., Lopez, Angel F.

“…Already 20 years have passed since the cloning of the granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor α-chain, the first member of the…”
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Dysregulation of BCL-2 family proteins by leukemia fusion genes by Brown, Lauren M., Hanna, Diane T., Khaw, Seong L., Ekert, Paul G.

“…The genomic lesions that characterize acute lymphoblastic leukemia in childhood include recurrent translocations that result in the expression of fusion…”
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Crossing paths: interactions between the cell death machinery and growth factor survival signals by Brumatti, Gabriela, Salmanidis, Marika, Ekert, Paul G.

“…Cytokines and growth factors play a crucial role in the maintenance of haematopoietic homeostasis. They transduce signals that regulate the competing…”
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Whole-genome sequencing facilitates patient-specific quantitative PCR-based minimal residual disease monitoring in acute lymphoblastic leukaemia, neuroblastoma and Ewing sarcoma by Subhash, Vinod Vijay, Huang, Libby, Kamili, Alvin, Wong, Marie, Chen, Dan, Venn, Nicola C., Atkinson, Caroline, Mayoh, Chelsea, Venkat, Pooja, Tyrrell, Vanessa, Marshall, Glenn M., Cowley, Mark J., Ekert, Paul G., Norris, Murray D., Haber, Michelle, Henderson, Michelle J., Sutton, Rosemary, Fletcher, Jamie I., Trahair, Toby N.

“…Background Minimal residual disease (MRD) measurement is a cornerstone of contemporary acute lymphoblastic leukaemia (ALL) treatment. The presence of…”
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Unusual PDGFRB fusion reveals novel mechanism of kinase activation in Ph-like B-ALL by Sadras, Teresa, Jalud, Fatimah B., Kosasih, Hansen J., Horne, Christopher R., Brown, Lauren M., El-Kamand, Sam, de Bock, Charles E., McAloney, Lachlan, Ng, Ashley P., Davidson, Nadia M., Ludlow, Louise E. A., Oshlack, Alicia, Cowley, Mark J., Khaw, Seong L., Murphy, James M., Ekert, Paul G.

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Histone H3-wild type diffuse midline gliomas with H3K27me3 loss are a distinct entity with exclusive EGFR or ACVR1 mutation and differential methylation of homeobox genes by Ajuyah, Pamela, Mayoh, Chelsea, Lau, Loretta M. S., Barahona, Paulette, Wong, Marie, Chambers, Hazel, Valdes-Mora, Fatima, Senapati, Akanksha, Gifford, Andrew J., D’Arcy, Colleen, Hansford, Jordan R., Manoharan, Neevika, Nicholls, Wayne, Williams, Molly M., Wood, Paul J., Cowley, Mark J., Tyrrell, Vanessa, Haber, Michelle, Ekert, Paul G., Ziegler, David S., Khuong-Quang, Dong-Anh

“…Diffuse midline gliomas (DMG) harbouring H3K27M mutation are paediatric tumours with a dismal outcome. Recently, a new subtype of midline gliomas has been…”
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Advances in CAR T cell immunotherapy for paediatric brain tumours by Rao, Padmashree, Furst, Liam, Meyran, Deborah, Mayoh, Chelsea, Neeson, Paul J, Terry, Rachael, Khuong-Quang, Dong-Anh, Mantamadiotis, Theo, Ekert, Paul G

“…Brain tumours are the most common solid tumour in children and the leading cause of cancer related death in children. Current treatments include surgery,…”
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In vivo loss of tumorigenicity in a patient-derived orthotopic xenograft mouse model of ependymoma by Whitehouse, Jacqueline P, Hii, Hilary, Mayoh, Chelsea, Wong, Marie, Ajuyah, Pamela, Barahona, Paulette, Cui, Louise, Dholaria, Hetal, White, Christine L, Buntine, Molly K, Byrne, Jacob, Rodrigues da Silva, Keteryne, Howlett, Meegan, Girard, Emily J, Tsoli, Maria, Ziegler, David S, Dyke, Jason M, Lee, Sharon, Ekert, Paul G, Cowley, Mark J, Gottardo, Nicholas G, Endersby, Raelene

“…Ependymomas (EPN) are the third most common malignant brain cancer in children. Treatment strategies for pediatric EPN have remained unchanged over recent…”
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Efficacy of MEK inhibition in a recurrent malignant peripheral nerve sheath tumor by Nagabushan, Sumanth, Lau, Loretta M. S., Barahona, Paulette, Wong, Marie, Sherstyuk, Alexandra, Marshall, Glenn M., Tyrrell, Vanessa, Wegner, Eva A., Ekert, Paul G., Cowley, Mark J., Mayoh, Chelsea, Trahair, Toby N., Crowe, Philip, Anazodo, Antoinette, Ziegler, David S.

“…The prognosis of recurrent malignant peripheral nerve sheath tumors (MPNST) is dismal, with surgical resection being the only definitive salvage therapy…”
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The BH3-Only Protein Bid Is Dispensable for DNA Damage- and Replicative Stress-Induced Apoptosis or Cell-Cycle Arrest by Kaufmann, Thomas, Tai, Lin, Ekert, Paul G., Huang, David C.S., Norris, Fiona, Lindemann, Ralph K., Johnstone, Ricky W., Dixit, Vishva M., Strasser, Andreas

“…Bid, a caspase-activated proapoptotic BH3-only protein, is essential for Fas-induced hepatocyte destruction. Recent studies published in Cell produced…”
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Diffuse leptomeningeal glioneuronal tumour (DLGNT) in children: the emerging role of genomic analysis by Manoharan, Neevika, Ajuyah, Pamela, Senapati, Akanksha, Wong, Marie, Mullins, Anna, Rodriguez, Michael, Doyle, Helen, McCowage, Geoff, Lau, Loretta M S, Ekert, Paul G, Ziegler, David S

“…Diffuse leptomeningeal glioneuronal tumours (DLGNT) represent rare enigmatic CNS tumours of childhood. Most patients with this disease share common…”
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ALLSorts: a RNA-Seq subtype classifier for B-Cell Acute Lymphoblastic Leukemia by Schmidt, Breon, Brown, Lauren M., Ryland, Georgina L., Lonsdale, Andrew, Kosasih, Hansen J., Ludlow, Louise E., Majewski, Ian J., Blombery, Piers, Ekert, Paul G., Davidson, Nadia M., Oshlack, Alicia

“…B-cell acute lymphoblastic leukemia (B-ALL) is the most common childhood cancer. Subtypes within B-ALL are distinguished by characteristic structural variants…”
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Integration of genomics, high throughput drug screening, and personalized xenograft models as a novel precision medicine paradigm for high risk pediatric cancer by Tsoli, Maria, Wadham, Carol, Pinese, Mark, Failes, Tim, Joshi, Swapna, Mould, Emily, Yin, Julia X, Gayevskiy, Velimir, Kumar, Amit, Kaplan, Warren, Ekert, Paul G, Saletta, Federica, Franshaw, Laura, Liu, Jie, Gifford, Andrew, Weber, Martin A, Rodriguez, Michael, Cohn, Richard J, Arndt, Greg, Tyrrell, Vanessa, Haber, Michelle, Trahair, Toby, Marshall, Glenn M, McDonald, Kerrie, Cowley, Mark J, Ziegler, David S

“…Pediatric high grade gliomas (HGG) are primary brain malignancies that result in significant morbidity and mortality. One of the challenges in their treatment…”
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